Lincomycin capsules 250 mg 20 pcs
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Description
Lincomycin is a broad-spectrum antibiotic that is used to treat diseases that are provoked by the activity of most gram-positive bacteria. When taking therapeutic doses of the drug, it acts bacteriostatic, and in higher concentrations has a pronounced bactericidal effect on the body.
Active ingredients
Lincomycin
Composition
1 ml contains: Active substance: iodine 12.5 mg, Excipients: potassium iodide, glycerol.
Pharmacological effect
Lincomycin is effective against gram-positive microorganisms (staphylococci, streptococci, pneumococci, diphtheria sticks) and some anaerobes, including the causative agents of gas gangrene and tetanus. It is also active against mycoplasmas. It does not affect gram-negative bacteria, fungi and viruses. Active against microorganisms, especially staphylococci resistant to other antibiotics. The resistance of microorganisms to lincomycin is produced slowly. In therapeutic doses, the drug acts bacteriostatic. The mechanism of action is associated with the suppression of protein synthesis by bacterial cells.
Pharmacokinetics
After ingestion, 20–30% of the dose of lincomycin is absorbed. The maximum concentration in the blood is reached in 2-4 hours. It penetrates into various organs and tissues, including bone tissue, into the bile. Through the blood-brain barrier penetrates poorly, but the permeability of the BBB increases with meningitis. Metabolized in the liver. Excreted in urine and feces.
Indications
According to the instructions to Lincomycin, the drug is prescribed in the following cases: - for the treatment of infectious diseases of upper respiratory tract and respiratory tract caused by microorganisms sensitive to the antibiotic (including otitis, bronchitis, pharyngitis, tracheitis, sinusitis, pneumonia, lung abscess, etc. .), - in infectious diseases of bones and joints, triggered by the activity of microorganisms sensitive to the drug, - for the treatment of infectious diseases of the skin and soft tissues caused by the microorganism sensitive to Linomycin mi (including infected purulent wounds, furunculosis, abscess, felon, erysipelas and mastitis). In dentistry, lincomycin is used for various infections of the maxillofacial apparatus.The main advantage of this drug compared with other antibiotics is its ability to be deposited in the teeth and bone tissue. Often Lincomycin in dentistry is used in combination with lidocaine to eliminate purulent processes in periodontitis, periodontitis and gingivitis. Also lincomycin in dentistry is effective if necessary to avoid the attachment of secondary infections on the surface of the wound after extraction of the tooth. Since there is no direct indication in the instruction about the need to use Lincomycin in dentistry, the question of the possibility of its use should be decided with a doctor.
Contraindications
- Hypersensitivity, - pregnancy (with the exception of cases when it is necessary according to "vital" indications), - lactation period, - severe hepatic and / or renal failure, - children's age (up to 3 years).
Use during pregnancy and lactation
Contraindicated.
Dosage and administration
Inside, 1-2 hours before or 2-3 hours after meals, 2-3 times a day with an interval of 8-12 hours. For adults, the daily dose is 1-1.5 g, one-time - 0.5 g. For children aged 3 to 14 years old daily dose - 30-60 mg / kg. The duration of treatment depending on the form and severity of the disease is 7-14 days (for osteomyelitis - 3 weeks or more). With long or repeated courses, treatment should be carry out under the control of the liver and kidneys.
Side effects
On the part of the digestive system: nausea, vomiting, diarrhea, epigastric pain, abdominal pain, glossitis, stomatitis, transient hyperbilirubinemia, increased activity of liver transaminases, with prolonged use - candidiasis of the gastrointestinal tract, pseudomembranous enterocolitis. Other fungal infections of the genital tract. From the blood-forming organs: reversible leukopenia, thrombocytopenia, neutropenia. Allergic reactions: urticaria, exfoliative dermatitis, angioedema, anaphylactic shock.
Overdose
No data on drug overdose.
Interaction with other drugs
With care: - Fungal diseases of the skin, - Mucous membranes of the mouth, vagina.
special instructions
Against the background of long-term treatment, periodic monitoring of liver transaminase activity and kidney function is necessary. Appointment to patients with hepatic impairment is permissible only for "vital" indications. When signs of pseudomembranous enterocolitis appear (diarrhea, leukocytosis, fever, abdominal pain, discharge with feces and mucus) in mild cases it is enough to cancel the drug and assign ion-exchange resins (Kolestiramine),in severe cases, recovery of fluid, electrolytes and protein is shown, vancomycin - by mouth, in a daily dose of 0.5-2 g (in 3-4 doses) within 10 days or bacitracin.