Lomexin cream vaginal 2% 78g
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Active ingredients
Fenticonazole
Release form
Cream
Composition
100 g of cream: fenticonazole nitrate 2 g. Additives: water - 60.5 g, glyceryl monostearate - 3 g, disodium edetate - 500 mg, fatty acid ester and macrogol - 15 g, lanolin hydrogenated - 1 g, almond oil - 10 g, propylene glycol - 5 g, cetyl alcohol - 3 g.
Pharmacological effect
Antifungal broad-spectrum drug for local use. Fenticonazole is a synthetic derivative of imidazole (its racemic mixture in the form of the nitric acid salt of fenticonazole). It has a local fungicidal and fungistatic effect. It also has antibacterial and anti-inflammatory effects. The mechanism of action is to inhibit the synthesis of ergosterol, which regulates the permeability of the cell membrane of fungi. It is active against the yeast fungi Candida spp. (including Candida albicans) and Gram-positive bacteria (Staphylococcus aureus, Streptococcus spp.), as well as against Trichomonas vaginalis. In contrast to other known azole compounds (in particular, econazole, miconazole and ketoconazole), fenticonazole inhibits the biosynthesis of Candida protese biosynthesis. below the IPC - from 0.25 to 16 mcg / ml. This action does not depend on the amount of antimycotic activity and is due to the inhibition of one of the stages of the formation of proteolytic enzymes by yeast-like fungi.
Pharmacokinetics
Fenticonazole is practically not subjected to systemic absorption, with prolonged topical administration, its concentration in the blood is not determined. The degree of absorption by mucous membranes is extremely small.
Indications
Vulvovaginal candidiasis; vaginal trichomoniasis.
Contraindications
I trimester of pregnancy; hypersensitivity to the drug.
Precautionary measures
The drug should not be prescribed during menstruation. The course of treatment is advisable to start after menstruation.
Use during pregnancy and lactation
Currently, data on the efficacy and safety of Lomexin in pregnancy and lactation (breastfeeding) are not available. The use of the drug in the first trimester of pregnancy is contraindicated.
Dosage and administration
Vaginal cream 2% is inserted deep into the vagina (approximately 5 g) 1 time / day in the evening, before bedtime, if necessary - 2 times / day, in the morning and in the evening. The treatment is carried out until complete clinical recovery, usually 3-6 days.
Side effects
Allergic reactions: rarely - urticaria, rash, erythema. Local reactions: burning, itching, local irritation. Lomexin is usually well tolerated, side effects are transient and do not require discontinuation of the drug.
Overdose
Currently, no cases of drug overdose have been reported for Lomexin.
Interaction with other drugs
Drug interactions or incompatibility of the drug Lomexin with other drugs are not described.
special instructions
With prolonged use of the drug may develop sensitization. In this case, it is necessary to stop treatment, and the patient should contact your doctor. If there is no effect during 3 weeks of therapy, treatment should be stopped and the diagnosis clarified. In order to avoid reinfection, it is recommended to simultaneously treat the partner with a cream that is applied to the head of the penis and foreskin.