Maalox chewable pills without sugar 20 pcs
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Active ingredients
Algeldrat + Magnesium hydroxide
Release form
Pills
Composition
1 tab.: Allegrite (in the form of hydrated aluminum oxide) 400 mg, which corresponds to the aluminum oxide content of 200 mg, magnesium hydroxide 400 mg Supplemental substances: starch with sucrose (sugar, confectionary) - 192 mg, sorbitol - 125 mg, mannitol - 10 mg, magnesium stearate - 7.2 mg, peppermint flavoring - 3.6 mg, sodium saccharinate - 3 mg, sucrose - 59.2 mg.
Pharmacological effect
Antacid medication. Neutralizes free hydrochloric acid of gastric juice, without causing its secondary hypersecretion. Due to the increase in the pH of gastric juice when taking the drug Maalox decreases the peptic activity of gastric juice. The drug also has an adsorbing and enveloping effect, which reduces the effect of damaging factors on the mucous membrane of the esophagus and stomach.
Pharmacokinetics
Magnesium hydroxide and aluminum hydroxide are considered to be local antacids that are practically not absorbed when taken in recommended doses and, accordingly, do not have systemic effects.
Indications
- gastric ulcer and duodenal ulcer in the acute phase; - acute gastroduodenitis; - chronic gastroduodenitis with normal or increased secretory function in the acute phase; - hernia of the esophageal orifice; - reflux esophagitis; - dyspeptic phenomena, such as discomfort or pain in the epigastrium , heartburn, sour eructation after errors in the diet, excessive use of ethanol, coffee, nicotine, etc. - dyspeptic phenomena, such as discomfort or epigastric pain, heartburn, sour belching (and their prevention), fuss coughing as a result of the use of certain drugs (including NSAIDs, GCS).
Contraindications
- severe renal insufficiency; - hypersensitivity to active substances and other components of the preparation; - hypophosphatemia; - fructose intolerance (due to the presence of sorbitol in the composition); - glucose-galactose malabsorption syndrome, sucrase / isomaltase deficiency ( the presence of sucrose in the composition of the drug) (for chewable pills); - intolerance to maltitol (for chewable pills (without sugar)); - children and adolescents under 15 years of age.With caution, use the drug in patients with porphyria on hemodialysis; in Alzheimer's disease; during pregnancy; for chewable pills - for diabetes mellitus (due to the presence of sucrose in the formulation).
Precautionary measures
Do not exceed recommended doses.
Use during pregnancy and lactation
To date, no specific teratogenic effects have been identified with the use of Maalox during pregnancy, however, due to the lack of clinical experience with its use in pregnancy, prescribing is possible only if the potential benefit of the therapy for the mother justifies the potential risk to the fetus. with the dosing regimen, the absorption of combinations of aluminum hydroxide and magnesium salts in the mother’s body is limited, therefore Maalox is considered compatible with the breast by feeding. In preclinical studies in animals, no clear indication of the teratogenic effect in aluminum hydroxide and magnesium hydroxide was obtained.
Dosage and administration
Tablets should be absorbed or chewed thoroughly. Adults and adolescents over 15 years old should be given 1-2 pills each. 3-4 times / day, 1-2 hours after meals and overnight. When reflux esophagitis, the drug is taken after a short period of time after meals. The maximum dose rate is 6 times / day. Do not take more than 12 tab./day. The duration of treatment should not exceed 2-3 months. When used occasionally, for example, with discomfort after errors in the diet, take 1-2 pills. once.
Side effects
If the recommended dosing regimen is observed, the side effects are insignificant. The frequency of adverse effects (according to the WHO classification): infrequent (≥0.1% and <1%); frequency unknown (according to available data, it is impossible to estimate the frequency of occurrence). From the immune system: frequency unknown - hypersensitivity reactions, anaphylactic reactions. Allergic reactions: frequency unknown - itching, urticaria, angioedema. From the digestive system: infrequently - diarrhea constipation. On the part of the metabolism: the frequency is unknown - hypermagnesium, hyperaluminiemia, hypophosphatemia (with long-term treatment or taking in high doses, or when taken in standard doses with no phosphate content in food), which can lead to increased bone resorption, hypercalciuria, osteomalacia.
Overdose
Symptoms: diarrhea, abdominal pain and vomiting are possible.In patients at risk, taking high doses of the drug may cause or aggravate intestinal obstruction or intestinal obstruction. Treatment: aluminum and magnesium are excreted in the urine. Losses and forced diuresis are replenished. Patients with renal insufficiency need to undergo hemodialysis or peritoneal dialysis.
Interaction with other drugs
With simultaneous use with quinidine, an increase in serum concentrations of quinidine and the development of quinidine overdose are possible. When administered simultaneously with Maalox, the following drugs are absorbed from the gastrointestinal tract: histamine H2 receptor blockers, propranolol, atenolol, cefdinir, cefpodoxime, metoprolol, chloroquine, prostacyclin, prostagolov, blockers. , digoxin, bisphosphonates, ethambutol, isoniazid, fluoroquinolones, sodium fluoride, GCS (described for prednisolone and dexamethasone), indomethacin, ketoconazole, lin ozamidov, neuroleptics, phenothiazine derivatives, penicillamine, rosuvastatin, iron salts, sodium levothyroxine. In the case of a 2-hour interval between taking these drugs and Maalox and the 4-hour interval between taking fluoroquinolones and Maalox, in most cases this undesirable interaction can be avoided. When using Maalox with polystyrenesulfonate (kayeksalat) together, you should be careful because of possible risk of reducing the efficiency of potassium binding by resin and the development of metabolic alkalosis in patients with renal insufficiency (for aluminum hydroxide and magnesium hydroxide) and about intestinal structures (for aluminum hydroxide). With the combination of aluminum hydroxide with citrates, plasma concentrations of aluminum may increase, especially in patients with renal insufficiency.
special instructions
Aluminum hydroxide can cause constipation, an overdose of magnesium salts can lead to a weakening of intestinal peristalsis; in high-risk patients (patients with renal insufficiency, elderly people), taking high doses of the drug can cause or aggravate intestinal obstruction and intestinal obstruction. Aluminum hydroxide is poorly absorbed from the gastrointestinal tract, therefore, patients with normal renal function have a systemic effect rarely.However, long-term treatment, use of the drug in excessively high doses, or use of the drug in usual doses against the background of reduced intake of phosphates from food can lead to phosphate deficiency (due to the binding of aluminum to phosphate), which is accompanied by increased bone resorption and hypercalciuria. osteomalacia. Patients at risk of developing phosphate deficiency or long-term use of the drug should be treated under medical supervision. In case of impaired renal insufficiency, plasma concentrations of magnesium and aluminum may increase. In these patients with prolonged use of the drug Maalox in high doses may develop encephalopathy, dementia, microcytic anemia or worsening osteomalacia caused by dialysis. to correct the treatment. The 2-hour interval between the use of the drug Maalox and other drugs should be observed. Long-term use of the drug Maalox should be avoided in case of renal failure. Despite the fact that the drug is released without a prescription, before using the drug during pregnancy and lactation (breastfeeding), as well as in adolescents, it is recommended to consult a doctor. Aluminum hydroxide with a low phosphate content in the diet can lead to the development of phosphorus deficiency in the body . Therefore, its use, especially long-term, should provide sufficient intake of phosphates from food. The drug is permeable to X-rays. When using the drug in patients with diabetes mellitus, the presence of sucrose in the composition of Maalox chewable pills should be taken into account. The effect on driving ability and control mechanisms The drug does not affect the ability to drive vehicles and work with mechanisms.