Miramistin solution for local use with a spray. 0.01% 50ml
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Active ingredients
Miramistin
Release form
Solution
Composition
Benzyldimethyl [3- (myristoylamino) propyl] ammonium chloride monohydrate per 1 l-100 mg
Pharmacological effect
Miramistin; has a broad spectrum of antimicrobial action, including hospital strains resistant to antibiotics; and others), aerobic and anaerobic bacteria, defined in the form of monocultures and microbial associations, including hospital strains with multiresistance to antibiotics.; It has antifungal effect on Ascomycetes of the genus Aspergillus and the genus Penicillium, yeast (Rhodoto rula rubra, Torulopsis gabrata, etc.) and yeast-like fungi (Candida albicans, Candida tropicalis, Candida krusei, Pityrosporum orbiculare (Malassezia furfur), etc.), dermatophytes (Trichophyton rubrum, Trichophyton mentagrotes, and Trichophytonhophtophros, in trichophytonhophtophrithophtophrithophtophrithophtophrithophtophritrathrothrithophtophritrathrothrothritis, Trichophyton rubrum, Trichophyton rubrum, Trichophyton rubrum, Trichophyton rubrum, Trichophyton rubrum etc. , Trichophyton violacent, Epidermophyton Kaufman-Wolf, Epidermophyton floccosum, Microsporum gypseum, Microsporum canis, etc.), as well as other pathogenic fungi, in the form of monocultures and microbial associations, including fungal microflora with resistance to chemotherapeutic drugs. active against intrusive viruses (herpes viruses, human immunodeficiency virus and other s) .; Miramistin; acts on sexually transmitted pathogens (Chlamydia spp., Treponema spp., Trichomonas vaginalis, Neisseria gonorrhoeae and others); Effectively prevents infection of wounds and burns. Activates regeneration processes. Stimulates protective reactions at the site of use, due to the activation of the absorption and digestive functions of phagocytes, potentiates the activity of the monocyte-macrophage system. It has a pronounced hyperosmolar activity, as a result of which it suppresses wound and perifocal inflammation, absorbs purulent exudate, contributing to the formation of a dry scab. Does not damage granulations and viable skin cells, does not inhibit marginal epithelization.; Does not have a local irritant effect and allergenic properties.
Pharmacokinetics
When applied topically, the drug does not have the ability to be absorbed through the skin and mucous membranes.
Indications
For use in otorhinolaryngology: - complex treatment of acute and chronic otitis, sinusitis, tonsillitis, laryngitis, pharyngitis; - complex treatment of acute pharyngitis and / or exacerbation of chronic tonsillitis in children aged 3 to 14. For use in dentistry: - treatment and prevention of infectious and inflammatory diseases of the oral cavity: stomatitis, gingivitis, periodontitis, periodontitis; - hygienic processing of removable dentures.; For use in surgery,traumatology: - prevention of suppuration and treatment of purulent wounds; - treatment of purulent-inflammatory processes of the musculoskeletal system. For use in obstetrics and gynecology: - prevention and treatment of suppurations of postpartum injuries, wounds of the perineum and vagina, postpartum infections; - prevention and treatment of inflammatory diseases (vulvovaginitis, endometritis); For use in combustiology: - treatment of superficial and deep burns of grade II and III; - preparation of burn wounds for dermatoplasty.; For use in dermatology, venereology: - treatment and prevention of pyoderma and dermatomycosis, candidiasis of the skin and mucous membranes, foot mycoses; - Individual prevention of sexually transmitted diseases (syphilis, gonorrhea, chlamydia, trichomoniasis, genital herpes, genital candidiasis, etc.) and non-specific nature.
Contraindications
Individual intolerance to the drug.
Use during pregnancy and lactation
Used in obstetrics according to indications.; Data on the safety of the drug during lactation (breastfeeding) is not provided.
Dosage and administration
When purulent sinusitis - during the puncture, the maxillary sinus is washed with a sufficient amount of the drug.; Tonsillitis, pharyngitis and laryngitis are treated by gargling and / or irrigation with a spray nozzle 3-4 times by pressing 3-4 times / day. The amount of the drug for 1 rinse 10-15 ml.; For stomatitis, gingivitis, periodontitis, it is recommended to rinse the oral cavity 10-15 ml of the drug 3-4 times / day. When used in surgery, traumatology, combustiology with preventive and therapeutic purposes irrigate the surface of wounds and burns, loosely tampon wounds and fistulous passages, fix gauze tampons moistened with the preparation. The treatment procedure is repeated 2-3 times / day for 3-5 days. A highly effective method of active drainage of wounds and cavities with a daily consumption of up to 1 l of the drug. When used in obstetrics and gynecology for the prevention of postpartum infection, it is used in the form of vaginal irrigation before delivery (5-7 days), at birth after each vaginal examination and in postpartum a period of 50 ml of the drug in the form of a tampon with an exposure time of 2 hours, for 5 days. For the convenience of vaginal irrigation, the use of a gynecological attachment is recommended.The contents of the vial are inserted into the vagina with the help of a gynecological attachment. During delivery of women by caesarean section, the vagina is treated immediately before the operation, the uterus and incision are made during the operation, and in the postoperative period tampons moistened with the preparation are introduced into the vagina with an exposure of 2 h for 7 days. Treatment of inflammatory diseases is carried out by a course for 2 weeks by intravaginal administration of tampons with the drug, as well as by the method of medicinal electrophoresis. For the prevention of sexually transmitted diseases, the drug is effective if it is used no later than 2 hours after sexual intercourse. The contents of the vial using urological applicator enter into the urethra for 2-3 minutes: men (2-3 ml), women (1-2 ml) and into the vagina (5-10 ml). For convenience, the use of gynecological attachments is recommended. Treat the skin of the inner thighs, pubis, genitals. After the procedure it is recommended not to urinate for 2 hours; In the complex treatment of urethritis and urethroprostatitis, 2-3 ml of the drug is injected into the urethra 1-2 times / day, the course of treatment is 10 days. In acute pharyngitis and / or exacerbation of chronic tonsillitis Pharynx irrigation with a spray nozzle. Children aged 3-6 years: single pressing on the head of the spray nozzle (3-5 ml per irrigation), 3-4 times / day; children aged 7-14 years old by pressing twice (5-7 ml per irrigation), 3-4 times / day; children older than 14 years of age 3-4 times pressing (10-15 ml per irrigation), 3-4 times / day. The duration of therapy ranges from 4 to 10 days depending on the timing of remission.; Terms of use of the drug; The drug is ready for use.; Instructions on the use of packaging with a spray nozzle; 1. Remove the cap from the vial, from the 50 ml vial also remove the urological applicator; 2. Remove the attached spray nozzle from the protective packaging.; 3. Attach the spray nozzle to the bottle.; 4. Re-activate the nebulizer by pressing.; Instructions on the use of a 50 ml or 100 ml package with a gynecological unit; 1. Remove the cap from the bottle.; 2. Remove the enclosed gynecological attachment from the protective packaging.; 3. Attach the gynecological attachment to the vial without removing the urological applicator.
Side effects
Local reactions: in some cases, a sensation of light burning may occur at the site of application, which passes on its own, after 15-20 seconds, and does not require discontinuation of the drug. Allergic reactions.
Overdose
Data on drug overdose Miramistin; not.
Interaction with other drugs
With simultaneous use with antibiotics, their antibacterial and antifungal properties increased.