Nystatin ointment 100000 units 30g
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Active ingredients
Nystatin
Release form
Ointment
Composition
Active substance: in 1 g - nystatin 100 000 ADDITIVES: anhydrous lanolin, medical vaseline.
Pharmacological effect
Polyene antifungal antibiotic. It has antifungal (fungistatic and fungicidal) activity. The structure has a large number of double bonds that determine the high tropism of the substance to the sterol formations of the cytoplasmic membrane of fungi. As a result, the molecule is embedded in the cell membrane with the formation of a variety of channels that contribute to the uncontrolled transport of water, electrolytes and non-electrolytes. The cell loses its resistance to the effects of external osmotic forces and is lysed. Resistance develops very slowly. It is active against yeast-like fungi of the genus Candida and Aspergillus. It has fungistatic, and in large doses - fungicidal action. Tolerance to nystatin sensitive fungi develops very slowly.
Pharmacokinetics
Practically not absorbed in the digestive tract. It has a weak resorptive effect.
Indications
- Candidiasis of the skin and mucous membranes; - Candidiasis of internal organs; - Prevention of candidiasis with long-term antimicrobial therapy, especially in exhausted and debilitated patients.
Contraindications
Hypersensitivity to the drug.
Use during pregnancy and lactation
Nystatin is contraindicated for use in pregnancy.
Dosage and administration
Outwardly. The ointment is applied to the affected areas 2 times a day, it can be used as a dressing, applied for 12-24 hours. The course of treatment is 10-14 days.
Side effects
Pruritus, rash, fever, chills and allergic reactions are possible.
Overdose
Currently, cases of drug overdose Nystatin were reported.
Interaction with other drugs
With the simultaneous use of nystatin with clotrimazole, the activity of the latter is reduced.
special instructions
With the development of adverse reactions should reduce the dose or cancel the drug.