Oxytocin solution for injection 5me ml ampoules 1ml N5
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Active ingredients
Oxytocin
Release form
Solution
Composition
1 ml contains: Active substance: synthetic oxytocin 5 IU.
Pharmacological effect
Hormone posterior lobe of the pituitary gland. It has a stimulating effect on the smooth muscles of the uterus, increases the contractile activity and to a lesser extent the tone of the myometrium. In small doses, it increases the frequency and amplitude of uterine contractions, and in large doses or when administered again, it increases the tone of the uterus, increases its frequency and its contractions (up to tetanic). It causes increased secretion of prolactin, as well as a reduction in myoepithelial cells surrounding the alveoli of the mammary gland, increasing milk production. It has weak vasopressin-like antidiuretic properties.
Pharmacokinetics
After parenteral administration, T1 / 2 from plasma ranges from one to several minutes. Metabolized in the liver. During pregnancy, the specific enzyme oxytocinase, which inactivates endogenous and exogenous oxytocin, appears in the blood plasma, target organs, and placenta. A small amount is excreted by the kidneys in unchanged form.
Indications
Medication induction, stimulation of labor in its primary or secondary weakness, prevention and treatment of hypotonic bleeding, subinvolution of the uterus in the postpartum period and after an abortion, cesarean section (after removal of the afterbirth), incomplete abortion.
Contraindications
The discrepancy between the size of the fetus and the pelvis of the woman, the transverse and oblique position of the fetus, threatening rupture of the uterus, narrow pelvis, placenta previa; hypertensive contractions of the uterus, the presence of a scar on the uterus after a previous cesarean section. Increased sensitivity to oxytocin.
Precautionary measures
According to the indications associated with childbirth, apply only under the supervision of a physician in a hospital under the supervision of the contractile activity of the uterus, fetal condition, blood pressure and general condition of the woman.
Use during pregnancy and lactation
It is used in pregnancy according to indications with the obligatory consideration of contraindications. It contributes to increased secretion of milk.
Dosage and administration
Individual.The single dose for intramuscular administration varies from 2 to 10 IU, depending on the clinical situation; for the on / in the introduction (jet slowly or drip) a single dose of 5 IU.
Side effects
On the part of the endocrine system: vasopressin-like action. On the part of the digestive system: nausea, vomiting. On the part of the cardiovascular system: cardiac rhythm. On the part of the reproductive system: hypertonus of the uterus, discoordinated or excessively strong labor, uterine rupture, fetal distress bradycardia, arrhythmia, asphyxia), premature detachment of the placenta. Allergic reactions: skin rash, itching.
Overdose
Symptoms: hyperstimulation of the uterus until rupture, bleeding after childbirth, uteroplacental hypoperfusion, hypoxia and fetal hypercapnia, water intoxication (convulsions are possible). Treatment: drug withdrawal, forced diuresis, electrolyte balance normalization.
Interaction with other drugs
With simultaneous use with inhalants for anesthesia, the hypotensive effect of oxytocin is enhanced and its stimulating effect on the uterus is weakened. Prostaglandins potentiate the stimulating effect of oxytocin on the uterus. Oxytocin can potentiate the pressor action of sympathomimetic drugs.
special instructions
The introduction of oxytocin should be carried out only in a specialized medical hospital with strict medical control. Oxytocin should not be used for severe pre-eclampsic toxemia, severe cardiovascular disorders.