Picoprep powder effervescent for preparation of solution for oral administration 16.1 g 2 pcs
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Description
Picoprep effervescent powder with orange flavor has a laxative effect. The effect of the drug is manifested in a strong washing effect, which is combined with the effect of stimulating intestinal peristalsis, which causes its use to clean the intestine before conducting radiographic studies, colonoscopy or surgical procedures.
Active ingredients
Sodium picosulfate + Magnesium oxide light + Citric acid anhydrous
Composition
Magnesium oxide - 3.5 g, citric acid anhydrous - 12.0 g, sodium picosulfate monohydrate - 10 mg; Auxiliary in-va: potassium bicarbonate, sodium saccharinate dihydrate, orange flavor (dry extract of orange, lactose, xanthine gum. Ascorbic to-that, butylhydroxyanisol E320).
Pharmacological effect
The active ingredients of Picoprep are sodium picosulphate, which has a local laxative effect in the large intestine, and magnesium citrate, which is formed from citric acid and magnesium oxide when the powder is dissolved and acts as an osmotic laxative by retaining water in the large intestine. Intestinal cleansing occurs as a result of a powerful “scrubbing out” effect in combination with stimulation of peristalsis, which is necessary for radiological or endoscopic (colonoscopy) studies and surgical manipulations.
Pharmacokinetics
All active ingredients have a local action in the colon and are practically not absorbed.
Indications
To clean the intestines before X-ray examinations, endoscopy or before surgery.
Contraindications
Hypersensitivity to any of the components of the drug - congestive heart failure - impaired gastric emptying, gastrointestinal ulcers, toxic colitis, toxic megacolon, intestinal obstruction, nausea and vomiting, acute abdominal pathologies requiring surgical intervention, such as an acute appendicitis, I have a 4-dimension, I have a 4-gauge; obstruction or perforation - renal failure (due to the accumulation of magnesium in the blood plasma) - children's age up to 3 years.
Dosage and administration
For oral administration. The day before the procedure is recommended to reduce the number of meals.In order to avoid dehydration while taking the drug Picoprep®, it is recommended to observe the drinking regime. The contents of one sachet are dissolved in 150 ml of water, stirred for 2-3 minutes, cooled to an acceptable temperature and drunk. Adults and children over 9 years oldIf the procedure is scheduled for the first half of the day: Content The first sachet is taken after lunch or in the early evening (16-18 hours), drinking at least 5 glasses of 250 ml of water or clear liquid (water, non-carbonated soft drinks, tea, coffee, fruit juice without pulp). Content Take a bag at night (22-24 hours), drinking at least 3 cups of 250 ml of water or clear liquid. The last glass can be drunk no later than 1 hour before the procedure. If the procedure is scheduled for the second half of the day: The contents of the first sachet are taken in the evening (17-21 hours) on the day preceding the procedure, drinking at least 5 glasses of 250 ml of water or clear liquid. The contents of the second bag are taken in the morning (5-9 hours before the procedure), with at least 3 glasses of 250 ml of water or a clear liquid. The last glass can be drunk no later than 1 hour before the procedure.
Side effects
Rarely (less than 1/10 000) - hypersensitivity, anaphylactic reaction - hyponatremia - headache, confusion, epilepsy, clonic-tonic convulsions, convulsions - nausea, vomiting, abdominal pain, diarrhea, proctalgia - rash (including erythematosus and maulopathy. , pruritus, urticaria, purpura. Individual cases of aphtoid ileal ulcers of the ileum have been reported in a mild reversible form.
Interaction with other drugs
Since Picoprep is a laxative, it increases the rate of gastrointestinal transit. Consequently, the drug may alter the absorption of other oral medications (eg, antiepileptic and antidiabetic, contraceptives and antibiotics). The effectiveness of the drug Picoprep decreases while taking with laxatives, increasing the volume of intestinal contents. The drug should be used with caution in patients who are already taking drugs that cause hypokalemia (such as diuretics or corticosteroids, as well as drugs whose reception is associated with a particular risk of developing hypokalemia, for example, cardiac glycosides).Precautions should be made to assign Picoprep to patients taking nonsteroidal anti-inflammatory drugs or drugs that induce the syndrome of inadequate secretion of anti-diuretic hormone, for example, tricyclic anti-depressants, selective serotonin reuptake inhibitors, antipsychotic drugs and carbamazepine, because they can get a syringe.
special instructions
With extreme caution should use the drug after the recent surgical procedures in the gastrointestinal tract, as well as patients with impaired kidney function, heart disease or inflammatory bowel disease. The drug should be used with caution in patients using drugs that may affect the water and / or electrolyte balance, for example, diuretics, corticosteroids, lithium. Since Picoprep may alter the absorption of drugs intended for regular oral administration, in such cases it should be used with caution; for example, individual reports of convulsions in patients taking anti-epileptic drugs, which previously allowed to successfully control the course of epilepsy, were received. Insufficient oral consumption of water and electrolytes can lead to a clinically significant deficit, especially in debilitated patients. Therefore, elderly patients and debilitated patients, as well as patients with the risk of developing hypokalemia should be under medical supervision. In patients with signs or symptoms of hyponatremia, rapid corrective measures may be required to restore balance and electrolytes. It should consume a sufficient amount of fluid. The period of bowel cleansing should not exceed 24 hours, as a longer procedure may increase the risk of impaired water or electrolyte balance. The drug contains lactose, so it should not be used by patients with lactose intolerance. The drug is not intended to be used as a conventional detergent. Children The drug is used in children from 3 years under the supervision of a doctor in the hospital.Use during pregnancy or lactation Clinical experience with the use of the drug Picoprep during pregnancy is limited, so the drug should be used with caution, especially in the first trimester of pregnancy. Sodium picosulfate, magnesium citrate is not excreted in breast milk. Features of the influence of the drug on the ability to control vehicles and maintenance of moving mechanisms Given the possibility of convulsions, convulsions or confusion, during the period of use of the drug should refrain from driving vehicles or working with other mechanisms. Overdose Symptoms: The development of profuse diarrhea is possible. Treatment: general maintenance treatment and adequate fluid intake.