Polyoxidonium suppositories vaginal-rectal 12mg N10
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Description
Torpedo-shaped suppositories, light yellow in color with a slight specific smell of cocoa butter.
Suppositories should be uniform. At the cut, the presence of an air rod or a funnel-shaped recess.
Suppositories should be uniform. At the cut, the presence of an air rod or a funnel-shaped recess.
Active ingredients
Azoxymere Bromide
Release form
Suppositories
Composition
Active ingredient: Azoxymere bromide - 6 mg or 12 mg,
Excipients:
mannitol - 1.8 mg, povidone K 17 - 1.2 mg, cocoa butter - 1291.0 mg (for a dosage of 6 mg),
mannitol - 3.6 mg, povidone K 17 - 2.4 mg, cocoa butter - 1282.0 mg (for a dosage of 12 mg).
Excipients:
mannitol - 1.8 mg, povidone K 17 - 1.2 mg, cocoa butter - 1291.0 mg (for a dosage of 6 mg),
mannitol - 3.6 mg, povidone K 17 - 2.4 mg, cocoa butter - 1282.0 mg (for a dosage of 12 mg).
Pharmacological effect
Azoxymere bromide has a complex effect: immunomodulatory, detoxifying, antioxidant, mild anti-inflammatory.
The basis of the mechanism of the immunomodulating action of Azoxymere bromide is a direct effect on phagocytic cells and natural killers, as well as the stimulation of antibody production and synthesis of interferon-alpha and interferon-gamma.
Detoxification and antioxidant properties of Azoxymere bromide are largely determined by the structure and high molecular nature of the drug.
Azoximera bromide increases the body's resistance to local and generalized infections of bacterial, fungal and viral etiology. It restores immunity in secondary immunodeficiency states caused by various infections, injuries, complications after surgery, burns, autoimmune diseases, malignant tumors, the use of chemotherapeutic agents, cytostatics, steroid hormones.
Azoxymer bromide blocks soluble toxic substances and microparticles, has the ability to excrete toxins from the body, heavy metal salts, inhibits lipid peroxidation both by intercepting free radicals and by eliminating catalytically active Fe2 + ions. Azoximera bromide reduces the inflammatory response by normalizing the synthesis of pro- and anti-inflammatory cytokines.
Azoximer bromide is well tolerated, does not possess mitogenic, polyclonal activity, antigenic properties, does not have allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effects.
The basis of the mechanism of the immunomodulating action of Azoxymere bromide is a direct effect on phagocytic cells and natural killers, as well as the stimulation of antibody production and synthesis of interferon-alpha and interferon-gamma.
Detoxification and antioxidant properties of Azoxymere bromide are largely determined by the structure and high molecular nature of the drug.
Azoximera bromide increases the body's resistance to local and generalized infections of bacterial, fungal and viral etiology. It restores immunity in secondary immunodeficiency states caused by various infections, injuries, complications after surgery, burns, autoimmune diseases, malignant tumors, the use of chemotherapeutic agents, cytostatics, steroid hormones.
Azoxymer bromide blocks soluble toxic substances and microparticles, has the ability to excrete toxins from the body, heavy metal salts, inhibits lipid peroxidation both by intercepting free radicals and by eliminating catalytically active Fe2 + ions. Azoximera bromide reduces the inflammatory response by normalizing the synthesis of pro- and anti-inflammatory cytokines.
Azoximer bromide is well tolerated, does not possess mitogenic, polyclonal activity, antigenic properties, does not have allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effects.
Pharmacokinetics
Azoxymere bromide in suppositories with rectal administration has a high bioavailability (at least 70%), reaching a maximum concentration in the blood through
1 hour after administration. The half-distribution period is about 0.5 hours, the half-elimination period is 36.2 hours. In the body it is hydrolyzed to oligomers, which are mainly excreted by the kidneys. No cumulative effect.
1 hour after administration. The half-distribution period is about 0.5 hours, the half-elimination period is 36.2 hours. In the body it is hydrolyzed to oligomers, which are mainly excreted by the kidneys. No cumulative effect.
Indications
It is used in adults and children older than 6 years for the treatment and prevention of infectious and inflammatory diseases (viral, bacterial and fungal etiology), in the stage of exacerbation and remission.
For treatment (in complex therapy):
• acute and exacerbations of chronic recurrent infectious and inflammatory diseases of various localization, bacterial, viral and fungal etiology,
• inflammatory diseases of the urogenital tract (urethritis, cystitis, pyelonephritis, prostatitis, salpingoophoritis, endomyometritis, colpitis, cervicitis, cervicosis, bacterial vaginosis),
• various forms of pulmonary tuberculosis,
• allergic diseases (including pollinosis, bronchial asthma, atopic dermatitis), complicated by recurrent bacterial, fungal and viral infections,
• rheumatoid arthritis, complicated by recurrent bacterial, fungal and viral infections, on the background of long-term immunosuppressants,
• to activate regenerative processes (fractures, burns, trophic ulcers),
• in the complex therapy of oncological diseases during chemotherapy and radiation therapy, to reduce the nephritic and hepatotoxic effects of drugs.
For prophylaxis (monotherapy):
• recurrent herpetic infection of the urogenital tract,
• exacerbations of chronic foci of infection,
• influenza and other acute respiratory infections in the pre-epidemic and epidemic period in immunocompromised individuals,
• secondary immunodeficiency arising from aging or exposure to adverse factors.
For treatment (in complex therapy):
• acute and exacerbations of chronic recurrent infectious and inflammatory diseases of various localization, bacterial, viral and fungal etiology,
• inflammatory diseases of the urogenital tract (urethritis, cystitis, pyelonephritis, prostatitis, salpingoophoritis, endomyometritis, colpitis, cervicitis, cervicosis, bacterial vaginosis),
• various forms of pulmonary tuberculosis,
• allergic diseases (including pollinosis, bronchial asthma, atopic dermatitis), complicated by recurrent bacterial, fungal and viral infections,
• rheumatoid arthritis, complicated by recurrent bacterial, fungal and viral infections, on the background of long-term immunosuppressants,
• to activate regenerative processes (fractures, burns, trophic ulcers),
• in the complex therapy of oncological diseases during chemotherapy and radiation therapy, to reduce the nephritic and hepatotoxic effects of drugs.
For prophylaxis (monotherapy):
• recurrent herpetic infection of the urogenital tract,
• exacerbations of chronic foci of infection,
• influenza and other acute respiratory infections in the pre-epidemic and epidemic period in immunocompromised individuals,
• secondary immunodeficiency arising from aging or exposure to adverse factors.
Contraindications
• increased individual sensitivity,
• pregnancy, breastfeeding period,
• children's age up to 6 years,
• acute renal failure.
• pregnancy, breastfeeding period,
• children's age up to 6 years,
• acute renal failure.
Precautionary measures
If you have the diseases listed in this section, consult your doctor before you start taking the medicine:
• chronic renal failure (prescribed no more than 2 times a week).
• chronic renal failure (prescribed no more than 2 times a week).
Use during pregnancy and lactation
Contraindicated use during pregnancy and during breastfeeding (clinical experience with no).
In experimental use of the drug Polyoxidonium® in animals, no embryotoxic and teratogenic effects or effects on the development of the fetus were detected.
Before using Polyoxidonium®, if you are pregnant, or suggest that you might be pregnant, or are planning to become pregnant, you should consult with your doctor.
During the breastfeeding period, before using Polyoxidonium®, it is necessary to consult a doctor.
In experimental use of the drug Polyoxidonium® in animals, no embryotoxic and teratogenic effects or effects on the development of the fetus were detected.
Before using Polyoxidonium®, if you are pregnant, or suggest that you might be pregnant, or are planning to become pregnant, you should consult with your doctor.
During the breastfeeding period, before using Polyoxidonium®, it is necessary to consult a doctor.
Dosage and administration
Use the drug only in accordance with the indications, the method of application and in the doses indicated in the instructions.
If there is no improvement after treatment, or symptoms become worse, or new symptoms appear, you should consult your doctor.
Rectal and vaginal 1 time per day, every other day or 2 times per week.
If necessary, it is possible to conduct repeated courses of therapy in 3-4 months. When you reappoint the drug its effectiveness is not reduced.
Recommended regimens
For adult treatment:
- rectally, 1 suppository 1 time per day after bowel cleansing,
- vaginally in gynecological diseases, 1 suppository, 1 time per day (at night) is inserted into the vagina in the prone position.
• for chronic infectious and inflammatory diseases in the acute stage - suppositories 12 mg 1 time daily for 3 days, then every other day. The course of treatment - 10 suppositories,
• for acute infectious processes and for activation of regenerative processes (fractures, burns, trophic ulcers) - suppositories 12 mg 1 time per day. The course of treatment - 10 suppositories,
• for gynecological diseases - suppositories 12 mg 1 time per day every day for 3 days, then every other day. The course of treatment 10 suppositories,
• in case of exacerbation of urological diseases (urethritis, pyelonephritis, cystitis, prostatitis) - suppositories 12 mg once a day, every day. A course of treatment -
10 suppositories,
• for pulmonary tuberculosis - suppositories 12 mg 1 time daily for 3 days, then every other day. The course of treatment is 20 suppositories.Further, it is possible to use supportive therapy supportive therapy 6 mg 2 times a week, for a course of up to 2-3 months,
• in the complex therapy of oncological diseases during chemotherapy and radiation therapy - suppositories 12 mg daily 2-3 days before the start of a course of chemotherapy or radiation therapy. Next, 12 mg 2 times a week, up to
20 suppositories,
• with allergic diseases complicated by infectious syndrome - suppositories 12 mg 1 time per day every day. The course of treatment - 10 suppositories,
• for rheumatoid arthritis - suppositories 12 mg every other day. A course of treatment -
10 suppositories.
For prophylaxis (monotherapy):
• exacerbations of chronic foci of infections, recurrent herpetic infection of the urogenital tract - suppositories 12 mg every other day.
Course - 10 suppositories,
• flu and ARVI - suppositories 12 mg 1 time per day. Course - 10 suppositories,
• secondary immunodeficiencies resulting from aging - suppositories 12 mg 2 times a week. Course - 10 suppositories, 2-3 times a year.
For the treatment of children and adolescents from 6 to 18 years:
Children and adolescents from 6 to 18 years old suppositories are administered only rectally,
1 suppository 6 mg 1 time per day after bowel cleansing.
• for chronic infectious and inflammatory diseases in the acute stage - suppositories 6 mg 1 time daily for 3 days, then every other day. The course of treatment - 10 suppositories,
• for acute infectious processes and for activation of regenerative processes (fractures, burns, trophic ulcers) - suppositories 6 mg 1 time per day. The course of treatment - 10 suppositories,
• during exacerbation of urological diseases (urethritis, pyelonephritis, cystitis, prostatitis) - suppositories 6 mg 1 time per day, daily. A course of treatment -
10 suppositories,
• in case of pulmonary tuberculosis - suppositories of 6 mg 1 time per day every day for 3 days, then every other day. The course of treatment is 20 suppositories. Further, it is possible to use supportive therapy supportive therapy 6 mg 2 times a week, for a course of up to 2-3 months,
• in the complex therapy of oncological diseases during chemotherapy and radiation therapy - suppositories of 6 mg daily 2-3 days before the start of a course of chemotherapy or radiation therapy. Next, 6 mg 2 times a week, up to 20 suppositories,
• with allergic diseases complicated by infectious syndrome - suppositories 6 mg 1 time per day every day. The course of treatment - 10 suppositories,
• for rheumatoid arthritis - suppositories 6 mg every other day. A course of treatment -
10 suppositories.
For prophylaxis (monotherapy):
• exacerbations of chronic foci of infections, recurrent herpetic infection of the urogenital tract - suppositories 6 mg every other day.
Course - 10 suppositories,
• influenza and ARVI - suppositories 6 mg 1 time per day, Course 10 suppositories.
For patients who have received immunosuppressive therapy for a long time, cancer patients that have been exposed to radiation, have an acquired defect of the immune system - HIV, supportive therapy with Polyoxidonium (for adults 12 mg each, for children over 6 years old - for 6 mg 1- 2 times per week).
If there is no improvement after treatment, or symptoms become worse, or new symptoms appear, you should consult your doctor.
Rectal and vaginal 1 time per day, every other day or 2 times per week.
If necessary, it is possible to conduct repeated courses of therapy in 3-4 months. When you reappoint the drug its effectiveness is not reduced.
Recommended regimens
For adult treatment:
- rectally, 1 suppository 1 time per day after bowel cleansing,
- vaginally in gynecological diseases, 1 suppository, 1 time per day (at night) is inserted into the vagina in the prone position.
• for chronic infectious and inflammatory diseases in the acute stage - suppositories 12 mg 1 time daily for 3 days, then every other day. The course of treatment - 10 suppositories,
• for acute infectious processes and for activation of regenerative processes (fractures, burns, trophic ulcers) - suppositories 12 mg 1 time per day. The course of treatment - 10 suppositories,
• for gynecological diseases - suppositories 12 mg 1 time per day every day for 3 days, then every other day. The course of treatment 10 suppositories,
• in case of exacerbation of urological diseases (urethritis, pyelonephritis, cystitis, prostatitis) - suppositories 12 mg once a day, every day. A course of treatment -
10 suppositories,
• for pulmonary tuberculosis - suppositories 12 mg 1 time daily for 3 days, then every other day. The course of treatment is 20 suppositories.Further, it is possible to use supportive therapy supportive therapy 6 mg 2 times a week, for a course of up to 2-3 months,
• in the complex therapy of oncological diseases during chemotherapy and radiation therapy - suppositories 12 mg daily 2-3 days before the start of a course of chemotherapy or radiation therapy. Next, 12 mg 2 times a week, up to
20 suppositories,
• with allergic diseases complicated by infectious syndrome - suppositories 12 mg 1 time per day every day. The course of treatment - 10 suppositories,
• for rheumatoid arthritis - suppositories 12 mg every other day. A course of treatment -
10 suppositories.
For prophylaxis (monotherapy):
• exacerbations of chronic foci of infections, recurrent herpetic infection of the urogenital tract - suppositories 12 mg every other day.
Course - 10 suppositories,
• flu and ARVI - suppositories 12 mg 1 time per day. Course - 10 suppositories,
• secondary immunodeficiencies resulting from aging - suppositories 12 mg 2 times a week. Course - 10 suppositories, 2-3 times a year.
For the treatment of children and adolescents from 6 to 18 years:
Children and adolescents from 6 to 18 years old suppositories are administered only rectally,
1 suppository 6 mg 1 time per day after bowel cleansing.
• for chronic infectious and inflammatory diseases in the acute stage - suppositories 6 mg 1 time daily for 3 days, then every other day. The course of treatment - 10 suppositories,
• for acute infectious processes and for activation of regenerative processes (fractures, burns, trophic ulcers) - suppositories 6 mg 1 time per day. The course of treatment - 10 suppositories,
• during exacerbation of urological diseases (urethritis, pyelonephritis, cystitis, prostatitis) - suppositories 6 mg 1 time per day, daily. A course of treatment -
10 suppositories,
• in case of pulmonary tuberculosis - suppositories of 6 mg 1 time per day every day for 3 days, then every other day. The course of treatment is 20 suppositories. Further, it is possible to use supportive therapy supportive therapy 6 mg 2 times a week, for a course of up to 2-3 months,
• in the complex therapy of oncological diseases during chemotherapy and radiation therapy - suppositories of 6 mg daily 2-3 days before the start of a course of chemotherapy or radiation therapy. Next, 6 mg 2 times a week, up to 20 suppositories,
• with allergic diseases complicated by infectious syndrome - suppositories 6 mg 1 time per day every day. The course of treatment - 10 suppositories,
• for rheumatoid arthritis - suppositories 6 mg every other day. A course of treatment -
10 suppositories.
For prophylaxis (monotherapy):
• exacerbations of chronic foci of infections, recurrent herpetic infection of the urogenital tract - suppositories 6 mg every other day.
Course - 10 suppositories,
• influenza and ARVI - suppositories 6 mg 1 time per day, Course 10 suppositories.
For patients who have received immunosuppressive therapy for a long time, cancer patients that have been exposed to radiation, have an acquired defect of the immune system - HIV, supportive therapy with Polyoxidonium (for adults 12 mg each, for children over 6 years old - for 6 mg 1- 2 times per week).
Side effects
Very rarely: local reactions in the form of redness, swelling, itching of the perianal zone, vaginal itching due to individual sensitivity to the components of the drug.
If you notice any side effects that are not listed in the instructions, inform your doctor.
If you notice any side effects that are not listed in the instructions, inform your doctor.
Overdose
Cases of overdose are not registered.
Interaction with other drugs
Azoximer bromide does not inhibit CYP1A2, CYP2C9, CYP2C19, CYP2D6, and cytochrome P-450 isoenzymes, therefore the drug is compatible with many drugs, including antibiotics, antiviral, antifungal and antihistamine drugs, glucocorticosteroids and cyto cytochromes and cytochymes.
If you are taking the above or other medications (including non-prescription drugs), consult your doctor before you start taking Polyoxidonium.
If you are taking the above or other medications (including non-prescription drugs), consult your doctor before you start taking Polyoxidonium.
special instructions
With the development of an allergic reaction, discontinue use of the drug Polyoxidonium® and consult a doctor.
If necessary, discontinuation of drug therapy, cancellation can be carried out immediately. In case of missing a single dose of the drug, it is necessary to take it as soon as possible, but if the time for taking the next dose has arrived, do not increase the dose for reception.
Do not use the drug in the presence of visual signs of its unsuitability (packaging defect, suppository color change).
Influence on ability to drive vehicles and mechanisms
The use of the drug Polyoxidonium® does not affect the ability to drive vehicles, maintain mechanisms and other types of work that require high concentration of attention and speed of psychomotor reactions.
If necessary, discontinuation of drug therapy, cancellation can be carried out immediately. In case of missing a single dose of the drug, it is necessary to take it as soon as possible, but if the time for taking the next dose has arrived, do not increase the dose for reception.
Do not use the drug in the presence of visual signs of its unsuitability (packaging defect, suppository color change).
Influence on ability to drive vehicles and mechanisms
The use of the drug Polyoxidonium® does not affect the ability to drive vehicles, maintain mechanisms and other types of work that require high concentration of attention and speed of psychomotor reactions.
Storage conditions
In a dry place, at a temperature of from 2 to 15 ° C.
Keep out of the reach of children.
Keep out of the reach of children.
Shelf life after opening
2 years. Do not use the drug after the expiration date.