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Active ingredients
Levonorgestrel
Release form
Pills
Composition
Active ingredient: Levonorgestrel. Concentration of active ingredient (mg): 0, 75 mg
Pharmacological effect
It has pronounced progestogenic and anti-estrogenic properties. It causes inhibition of ovulation and changes in the endometrium, prevents implantation of a fertilized egg. Increases viscosity of cervical mucus, which prevents the promotion of sperm.
Pharmacokinetics
When ingestion quickly and completely absorbed from the gastrointestinal tract. Cmax in plasma is observed after 1.6 hours and amounts to 14.1 ng / ml. Associated with albumin and globulin that binds sex hormones. It penetrates into breast milk: when breastfeeding about 0.1% of levonorgestrel along with breast milk enters the body of a newborn. Levonorgestrel is metabolized in the liver, its biotransformation corresponds to the metabolism of steroids. Pharmacologically active metabolites of levonorgestrel are unknown. Concentration in the blood decreases in 2 phases, T1 / 2 is 2–7 hours. 60% of the drug in the form of metabolites is excreted in the urine, 40% in the feces.
Indications
Emergency (postcontal) contraception (after unprotected sex or unreliability of the contraceptive method used).
Contraindications
Hypersensitivity to any component of the drug, use in adolescents under 16 years of age, severe liver failure, pregnancy. Patients with rare hereditary diseases, such as lactose intolerance, lactase deficiency, or glucose-galactose malabsorption.
Precautionary measures
Although you can buy postinor without a prescription and take it on your own initiative, patients who have previously had allergic reactions to any medications are strongly advised to consult a doctor before using emergency contraception. Consultation with a doctor is also necessary for those who have diseases such as diabetes and migraine, and patients who suspect that they may be pregnant. Since postinor can cause dizziness, it is not recommended to drive any vehicles or work with equipment that is potentially dangerous for the patient herself or for other people for 24 hours after taking it.It is also necessary to limit the consumption of alcoholic beverages, and it is better to refuse them altogether for at least several days. Patients suffering from diabetes, after taking POSTINOR, must carefully monitor changes in blood sugar levels, since levonorgestrel may affect the effectiveness of antidiabetic drugs. Breastfeeding women before taking postinor, you should consult with your doctor - although it has not yet been established that this drug is dangerous for infants, this does not mean that it is completely harmless to them.
Use during pregnancy and lactation
In pregnancy, the drug is not applicable. Pregnancy is possible if sexual intercourse without protection occurred after the last menstruation and occurred more than 72 hours ago. In this case, the use of the drug will be ineffective. If menstruation is delayed for more than 5 days, or, although it appears on time, but its course is abnormal, as well as if pregnancy is suspected (nausea, vomiting, breast exertion, etc.), then you should consult a doctor in order to exclude the possibility of pregnancy. If, despite taking the drug Postinor, you become pregnant, then you need to consult a doctor. Currently, there is no evidence of the adverse effect of postinor pills on fetal development. At the same time, it is important to exclude the possibility of ectopic pregnancy, especially if after taking pills. Postinor, you have had a sharp pain in the lower part of ectopic pregnancy in the past, and after surgery or pelvic inflammatory processes.
Dosage and administration
The drug is administered orally. You must take 2 pills in the first 72 hours after unprotected intercourse. The second pill should be taken 12 hours (but not later than 16 hours) after taking the first tablet. To achieve a more reliable effect, both pills should be taken as soon as possible after unprotected intercourse (no later than 72 hours). If within three hours after 1 or 2 doses of pills Post it time to vomit, then you should take another pill Postinora. Postinor can be used at any time during the menstrual cycle. In the case of an irregular menstrual cycle, you must first exclude pregnancy.After taking the emergency contraceptive before the next menstruation occurs, local barrier contraceptive methods should be used (for example, a condom, cervical cap). The use of the drug for repeated unprotected intercourse during one menstrual cycle is not recommended due to the increase in the frequency of acyclic bleeding bleeding.
Side effects
Allergic reactions are possible: urticaria, rash, itching, swelling of the face. Adverse effects occurring with different frequencies (often: ≥1100, less than 110, very often: ≥110) and not requiring medical therapy: often: vomiting, diarrhea, dizziness, headache, breast tenderness, delayed menstruation (not more than 5 7 days), if menstruation is delayed for a longer period, it is necessary to exclude pregnancy. Very often: nausea, fatigue, abdominal pain, acyclic bleeding (bleeding).
Overdose
There are no data on serious side effects after taking a large dose of contraceptive. Symptoms: nausea, irregular menstruation. Treatment: symptomatic. There is no specific antidote.
Interaction with other drugs
If you are taking any medication listed in Section 3 less? In the cases below, you should see a doctor before using an emergency contraceptive, then the pharmacist should be aware of this. If you have any further questions, contact your pharmacist, doctor, or any emergency contraceptive center.
special instructions
Apply strictly on doctor's prescription to avoid complications. Postinor is recommended for women with a regular menstrual cycle. Re-use of the drug Postinor should be avoided during the same menstrual cycle due to the possibility of irregular menstruation. It is not allowed to use as a means of regular and continuous contraception, because it leads to a decrease in the effectiveness of the drug and an increase in adverse reactions. Postinor pills do not replace regular contraception. With regular sex life is recommended to use other methods of contraception. In case of uterine bleeding, a gynecological examination is recommended.If the pregnancy against the background of the Postinor has nevertheless developed, or Postinor was adopted against the background of the already existing pregnancy, the risk of negative effects on the fetus is not established. The drug does not adversely affect the ability to drive a car and the performance of work that requires a high rate of mental and physical reactions.