Progesterone solution, oil 2.5% 1 ml 10 pcs

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Active ingredients


Release form



Active ingredient: progesterone Active ingredient concentration (%): 2, 5%

Pharmacological effect

Progestin Hormone yellow body. Causes the transition of the mucous membrane of the uterus from the phase of proliferation caused by follicular hormone to the secretory phase, and after fertilization contributes to its transition to the state necessary for the development of a fertilized egg. Reduces the excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of the terminal elements of the mammary gland. Does not possess androgenic activity. Progesterone has a weak effect on protein metabolism, promotes fat deposition and glucose accumulation in the liver, and also reduces sodium reabsorption in the renal tubules. Progesterone has a blocking effect on the secretion of hypothalamic factors of LH and FSH release, inhibits the formation of gonadotropic hormones in the pituitary gland and inhibits ovulation.


After the i / m injection is absorbed quickly and almost completely. Metabolized in the liver, most metabolites form conjugates with glucuronic and sulfuric acids. T1 / 2 of plasma is a few minutes. Excreted in the urine - 50-60% and with the feces - more than 10%. The number of metabolites that are excreted in the urine varies depending on the phase of the corpus luteum.


Dysfunctional uterine bleeding, metrorrhagia, amenorrhea, habitual miscarriage. Contraception.


Severe dysfunction of the liver or kidneys, hepatitis, thromboembolic diseases, vaginal bleeding of not established genesis, carcinoma of the mammary gland (except in cases in which progesterone is used as part of a combination therapy of this disease).

Precautionary measures

Do not exceed recommended doses.

Use during pregnancy and lactation

In cases of extreme necessity, progesterone may be used during pregnancy with established deficiency of the yellow body hormones. Progesterone is not used in women planning pregnancy in the near future.

Dosage and administration

Progesterone is injected into the / m, adults, the highest single dose of 0.025 g (2.5 ml of 1% or 1 ml of 2.5% p-ra).

Side effects

On the part of the cardiovascular system: increased blood pressure. On the side of metabolism: edema. On the part of the digestive system: abnormal liver function, jaundice; rarely (with long-term use) - nausea, vomiting. From the endocrine system: rarely (with long-term use) - decreased libido, weight gain, pain and tension in the mammary glands, irregular uterine bleeding. From the CNS: rarely (with long-term use ) - headache, depression.


To date, no cases of overdose have been reported.

Interaction with other drugs

Reduces the intensity of the action of drugs that stimulate the smooth muscles of the uterus, anabolic steroids, gonadotropic hormones of the anterior pituitary gland. Reduces the lactogenic effect of oxytocin.

special instructions

It is used with caution in patients with cardiovascular diseases, abnormal liver or kidney function, diabetes, asthma, epilepsy, migraine, depression.