Reopolyglucin solution for infusions bottle 10% 200 ml N28
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Description
Solution for infusions Rheopoliglukin 10% is a polyfunctional plasma-substituting solution. Normalizes hemodynamics, increases the volume of fluid in the bloodstream.
Active ingredients
Dextran [cf. mass 30000-40000]
Release form
Solution
Composition
Dextran with a molecular weight of from 30,000 to 40,000 10 g per 100 ml
Pharmacological effect
Solutions of high molecular dextran with sodium chloride, glucose or mannitol, are polyfunctional plasma-substituting solutions. Normalize hemodynamics, increase the volume of fluid in the bloodstream. Solutions of low molecular weight dextran, in addition, contribute to the improvement of microcirculation, reduce the aggregation of blood cells, blood viscosity. Dextran solutions containing mannitol also have an osmo-diuretic effect.
Pharmacokinetics
Excreted by the kidneys (on the first day up to 70%), T1 / 2 - 6 hours.
Indications
Solutions of high molecular dextran: severe post-hemorrhagic hypovolemia, hypovolemic shock due to injury, blood loss during childbirth, as a result of ectopic pregnancy, etc. Hypovolemia due to plasma loss (burns, compression syndrome). Preoperative and postoperative prevention of embolism. Solutions of low molecular weight dextran: microcirculation disorders, traumatic shock, burn shock, compression syndrome. Septic shock. Replacement of plasma volume in blood loss in pediatrics. For filling the heart-lung machine (in certain proportions with blood). Dextran with a molecular weight of 1000: prevention of severe allergic reactions to the intravenous injection of dextran solutions.
Contraindications
Injuries to the skull with increased intracranial pressure, cerebral hemorrhage, and other cases where the administration of large amounts of fluid is not indicated. Oliguria and anuria, caused by organic kidney disease, heart failure, impaired coagulation and hemostasis, a tendency to allergic reactions. For solutions with glucose - diabetes mellitus and other disorders of carbohydrate metabolism.
Use during pregnancy and lactation
Data on the safety of the use of Reopolyglucin in these periods is not.
Dosage and administration
Solutions of high-molecular dextran are administered intravenously at a rate of 60-80 drops per minute in an amount of up to 2-2.5 liters (with significant blood loss, with the addition of blood). Solutions of low molecular weight dextran, when used as a blood substitute, are usually administered in the same doses. In other cases, the daily dose should not exceed 20 ml / kg. The rate of intravenous infusion is determined by the indications and the severity of the patient's condition. Dextran with a molecular weight of 1000 is injected into / in a jet of adults at a dose of 3 g (20 ml), children - at a dose of 45 mg / kg (0.3 ml / kg) - 1-2 minutes before the / infusion of dextran solution. The interval between the introduction of dextran with a molecular weight of 1000 and the infusion of the dextran solution should not exceed 15 minutes. If more than 15 minutes have passed, then the dextran with a molecular weight of 1000 should be entered again. It can be administered before each infusion of dextran solution, especially if more than 48 hours have passed since the previous infusion.
Side effects
Possible: allergic reactions. Rarely: arterial hypotension.
Overdose
Not described.
Interaction with other drugs
You must first check for compatibility of dextran with drugs that are scheduled for introduction into the infusion solution.
special instructions
In connection with possible allergic reactions, the first 10–20 ml of the solution for infusions is recommended to be administered slowly, observing the patient’s condition. Given the possibility of arterial hypertension, it should be borne in mind that appropriate means for intensive therapy may be required. Dextran with a molecular weight of 1000 can not be diluted or mixed with solutions of dextran for infusion. Dextran with a molecular weight of 1000 can be introduced into / in through a Y-shaped branch or rubber tube of the infusion system, provided that during the injection process there is no significant dilution of the drug.