More info
Active ingredients
Acenocoumarol
Release form
Pills
Composition
Tablets 1 tab. acenocoumarol 2 mg.
Pharmacological effect
Anticoagulant of indirect action, is an antagonist of vitamin K. Violates the synthesis of prothrombin (blood coagulation factor II), proconvertin (blood coagulation factor VII), factors IX and X. The maximum effect is observed 24-48 hours after ingestion. After the abolition of acenocumarol, the original prothrombin content is restored on the 2-4th day.
Pharmacokinetics
When ingestion acenocoumarol has a high degree of absorption, Cmax is achieved in 1-8 hours, binding to plasma proteins is 99%. Cumulates when re-taking. Gets through a placental barrier, it is allocated with breast milk.
Indications
Thrombosis, thrombophlebitis, thromboembolic complications of myocardial infarction, embolic stroke, thromboembolism of various organs. In surgical practice - to prevent thromboembolic complications in the postoperative period.
Contraindications
Hemorrhagic diathesis, hypocoagulation, hypoprothrombinemia (less than 70%), renal failure, marked impaired liver function, arterial hypertension, pericarditis, erosive and ulcerative lesions of the gastrointestinal tract, malignant neoplasms, diabetic retinopathy, physical exhaustion, hypovitaminosis K, a rash, a rash, a stomach, a hypotamines, a rash, a malignant neoplasm, a malignant neoplasm, a diaperic rash, a rash, a hypovitaminosis sensitivity to acenocumarol.
Use during pregnancy and lactation
Contraindicated: pregnancy, lactation.
Dosage and administration
Set individually, depending on the evidence of blood coagulation. On the 1st day of treatment, the dose is 8-16 mg / day, on the 2nd day - 4-12 mg / day; on the 3rd day - 6 mg. Maintenance dose (after reducing the prothrombin index to 50%) - 1-6 mg. The frequency of admission - 1 time / day at the same time.
Side effects
From the blood coagulation system: bleeding, hemorrhages on the skin and mucous membranes (according to the degree of probability reduction): hematuria, bleeding from the gums, petechiae, post-traumatic hematoma, melena, metrorrhagia, hemarthrosis, hemorrhagic stroke; withdrawal syndrome - increased risk of blood clots. On the part of the digestive system: nausea, diarrhea. Dermatological reactions: alopecia, skin necrosis.Allergic reactions: fever, skin rashes. Other: headache.
Interaction with other drugs
With simultaneous use of barbiturates reduce the effectiveness of acenocoumarol; salicylates - increase its effectiveness. With simultaneous use of acenocoumarol enhances the effect of oral hypoglycemic agents, the toxic effects of phenytoin and the ulcerogenic action of GCS.
special instructions
During treatment, it is necessary to carefully monitor the general condition of the patient and changes in the blood coagulation system. If you appear on the background of therapy bleeding or bleeding acenocoumarol should be canceled.