Sorbifer Durules pills 50 pcs
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Active ingredients
Iron Sulfate + Ascorbic Acid
Release form
Pills
Composition
1 tablet contains: Active substance: Ferrous sulfate (II) 320 mg, ascorbic acid (Vit. C) 60 mg. Auxiliary substances: magnesium stearate, povidone K-25, polyethylene powder, carbomer 934P. Coat composition: hypromellose, macrogol 6000, titanium dioxide, iron oxide yellow, paraffin solid.
Pharmacological effect
Iron is an indispensable component of the body, necessary for the formation of hemoglobin and the flow of oxidative processes in living tissues. The drug is used to eliminate iron deficiency. Durules technology provides a gradual release of the active ingredient (iron ions) for a long time. Sorbifer Durules plastic matrix pills are completely inert in the digestive juice, but completely disintegrate under the action of intestinal peristalsis, when the active ingredient is completely released. Ascorbic acid helps to improve the absorption of iron.
Pharmacokinetics
AbsorptionDurules is a technology that provides a gradual release of the active substance (iron ions), a steady flow of the drug. Acceptance of 100 mg 2 times / day provides 30% more absorption of iron from the drug Sorbifer Durules compared with conventional iron preparations. Absorption and bioavailability of iron are high. Iron is absorbed predominantly in the duodenum and proximal jejunum. Distribution: Plasma proteins are 90% or more. Deposited as ferritin or hemosiderin in hepatocytes and cells of the system of phagocytic macrophages, a small amount in the form of myoglobin in muscles. Excretion of T1 / 2 is 6 hours.
Indications
- iron deficiency anemia; - iron deficiency; - prophylactic use during pregnancy, lactation, in blood donors.
Contraindications
- esophageal stenosis and / or other obstructive changes in the digestive tract; - increased iron content in the body (hemosiderosis, hemochromatosis); - violation of iron utilization (lead anemia, sideroblastic anemia, hemolytic anemia); - children under 12 years old (due to lack of clinical data); - hypersensitivity to the components of the drug. The drug should be used with caution in case of gastric ulcer and duodenal ulcer, inflammatory bowel diseases (enteritis, diverticulitis, ulcerative Olite, Crohn's disease).
Use during pregnancy and lactation
Perhaps the use of the drug Sorbifer Durules during pregnancy and lactation according to indications.
Dosage and administration
The drug is taken orally. Coated pills can not be divided or chewed. The tablet should be swallowed whole and washed down with at least half a glass of liquid. Adults and adolescents are prescribed 1 tab. 1-2 times / day. If necessary, for patients with iron deficiency anemia, the dose can be increased to 3-4 tab./day in 2 doses (in the morning and in the evening) for 3-4 months (until the iron depot is replenished in the body). During pregnancy and lactation for the purpose of prevention appoint 1 tab. / day; for treatment prescribed on 1 tab. 2 times / day (morning and evening). The treatment should be continued until the optimal level of hemoglobin is reached. For further replenishment of the depot, it may be necessary to continue taking the drug for another 2 months.
Side effects
On the part of the digestive system: nausea, vomiting, abdominal pain, diarrhea, constipation (the frequency of these side effects may increase with increasing doses from 100 mg to 400 mg); rarely (<1/100) - ulcerative lesion of the esophagus, esophageal stenosis. Allergic reactions: rarely - itching, rash. On the CNS side: rarely - headache, dizziness. Other things: rarely - hyperthermia of the skin, weakness.
Overdose
Symptoms: abdominal pain, vomiting and diarrhea with blood, fatigue or weakness, hyperthermia, paresthesia, pale skin, cold, sticky sweat, acidosis, weak pulse, decreased blood pressure, palpitations. In severe overdose, signs of peripheral circulatory collapse, coagulopathy, hyperthermia, hypoglycemia, liver damage, renal failure, muscle cramps and coma may appear after 6-12 hours. Treatment: in case of overdose, consult a doctor immediately. It is necessary to wash the stomach, inside - a raw egg, milk (to bind iron ions in the digestive tract); deferoxamine is administered. Symptomatic therapy.
Interaction with other drugs
Sorbifer Durules can reduce the absorption of simultaneously used enoxacin, clodronate, grepafloxacin, levodopa, levofloxacin, methyldopa, penicillamine, tetracyclines, and thyroid gland hormones. Simultaneous use of the drug Sorbifer Durules and antacid preparations containing aluminum hydroxide and carbon monoxide containing calcium hydroxide and carbon monoxide.Between taking the drug Sorbifer Durules and any of these drugs should maintain the maximum possible time interval. The recommended minimum time interval between doses is 2 hours, except when taking tetracyclines, when the minimum interval should be 3 hours. Sorbifer Durules should not be combined with the following drugs: ciprofloxacin, doxycycline, norfloxacin and ofloxacin.
special instructions
When using the drug may darken the feces, which has no clinical significance.