Ultop capsules 40 mg 14 pcs
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Description
Capsules Ultop is an inhibitory agent.
Composition
Omeprazole - 40 mg. Excipients: sugar grits (sucrose, starch syrup) - 160 mg, hyprolosis - 9.6 mg, magnesium hydroxycarbonate (magnesium carbonate, heavy) - 40 mg, sucrose - 64.4 mg, corn starch - 53 mg, sodium lauryl sulfate - 5 mg, copolymer methacrylic acid and ethyl acrylate (1: 1) 30% dispersion - 62 mg, talc - 12 mg, macrogol 6000 - 6.2 mg, titanium dioxide - 3.8 mg.
Pharmacokinetics
Suction and distribution. After taking the drug inside omeprazole is rapidly absorbed from the gastrointestinal tract, Cmax in plasma is achieved in 0.5-1 hours. Bioavailability is 30-40%. Plasma protein binding is about 90-95%. Metabolism and excretion. Omeprazole is almost completely biotransformed in the liver. It is an inhibitor of the enzyme system CYP 2C19. Excreted mainly by the kidneys (70-80%) and with bile (20-30%). T1 / 2 - 0.5-1 hours. Pharmacokinetics in special clinical situations. In chronic renal failure, elimination decreases in proportion to the decrease in CC. In the elderly, the elimination of omeprazole is reduced. When liver failure T1 / 2 - 2-3 hours.
Indications
Short-term treatment of non-ulcer dyspepsia, long-term supportive therapy to prevent the recurrence of gastroesophageal reflux disease, long-term supportive therapy to prevent the recurrence of gastric and duodenal ulcers.
Contraindications
Children's age, pregnancy, lactation (breastfeeding), hereditary fructose intolerance, glucose-galactose malabsorption syndrome, sucrase / isomaltase deficiency, hypersensitivity to the components of the drug. Precautions should be prescribed the drug for renal or hepatic failure.
Use during pregnancy and lactation
Do not use Ultop during pregnancy. If necessary, the appointment of the drug during lactation is necessary to solve the issue of termination of breastfeeding.
Dosage and administration
The drug is taken orally, before meals (because food intake slows down the absorption of the drug), drinking a small amount of water (the contents of the capsule can not be chewed).
Side effects
In rare cases, usually reversible adverse reactions may occur.
Overdose
Symptoms: abdominal pain, drowsiness, headache, dizziness, dry mouth, tachycardia, arrhythmia, blurred vision, agitation, confusion, increased sweating, nausea, in rare cases - cramps, shortness of breath, hypothermia. There is no specific antidote. Treatment: symptomatic.
Interaction with other drugs
Long-term use of omeprazole in a dose of 20 mg 1 time / day in combination with caffeine, theophylline, piroxicam, diclofenac, naproxen, metoprolol, propranolol, ethanol, cyclosporine, lidocaine, quinidine and estradiol did not change their plasma concentration. No interaction of omeprazole with concomitant antacids was observed. Omeprazole can reduce the absorption of ampicillin esters, iron salts, itraconazole and ketoconazole (because omeprazole increases the pH of the stomach). As an inhibitor of cytochrome P450, omeprazole can increase the concentration and reduce the excretion of diazepam, indirect anticoagulants, phenytoin, which in some cases may require a reduction in doses of these drugs. With simultaneous reception increases the absorption of omeprazole and clarithromycin.