Xantinol nicotinate injection solution ampoules 15% 2ml N10
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Active ingredients
Xantinol nicotinate
Release form
Solution
Composition
1 ampoule contains: Active substance: xanthinol nicotinate 15%.
Pharmacological effect
Microcirculation improving agent; combines the properties of theophylline and nicotinic acid. It causes the expansion of peripheral vessels, improves collateral circulation, improves microcirculation, improves oxygenation and nutrition of tissues. It has an antiplatelet effect, activates the processes of fibrinolysis, improves cerebral circulation, reduces blood viscosity. Enhances oxidative phosphorylation and ATP synthesis. By blocking adenosine receptors and PDE, it increases the content of cAMP in the cell, stimulates the synthesis of NADF and NADF in the substrate. Reducing CRPS and increasing myocardial contractions, increases the minute volume of blood and increases the cerebral circulation, reduces the severity of cerebral hypoxia effects. nasal and oral cavities: sharpens the olfactory and taste sensitivity. In this regard, the smell and taste of alcoholic drinks and dishes offered during the nicotine-like reaction is perceived more harsh and unpleasant. With prolonged use, it has an anti-atherosclerotic effect, activates fibrinolysis processes, reduces cholesterol and atherogenic lipids, increases the activity of lipoprotein lipase, reduces blood viscosity, reduces aggregation platelet count.
Indications
Raynaud's disease, obliteration of cerebral vessels, hypercholesterolemia, hypertriglyceridemia, intrauterine and postpartum fetal asphyxia, dermatosis due to violation of feke vascular genesis, scleroderma, scleredema Buschke.
Contraindications
Acute bleeding, acute myocardial infarction, mitral stenosis, acute heart failure, chronic heart failure in the decompensation stage,arterial hypotension, gastric ulcer and duodenal ulcer in the acute phase, acute renal failure, glaucoma, pregnancy, hypersensitivity to xanthinol nicotinate.
Use during pregnancy and lactation
Contraindicated in pregnancy and lactation.
Dosage and administration
Inside - 150-600 mg 3 times / day after meals. V / m is administered in a dose of 300-600 mg 1-3 times / day; in / in the jet administered slowly, in the prone position, at a dose of 300-800 mg 1-3 times / day. For intravenous drip administration, the dose is 150-900 mg. In acute disorders of the blood supply to the tissues simultaneously with the parenteral administration of xanthinol, nicotinate is administered orally 300 mg 3 times / day.
Side effects
On the part of the cardiovascular system: possible reduction of blood pressure, transient sensation of heat, redness of the skin. On the part of the digestive system: rarely - nausea, diarrhea, anorexia, gastralgia; with prolonged use in high doses, it is possible to increase the level of transaminases and alkaline phosphates. Others: weakness, dizziness; with prolonged use in high doses, it is possible to change the tolerance to glucose, an increase in the level of uric acid in the blood serum.
Interaction with other drugs
With simultaneous use with drugs that have a hypotensive effect (beta-blockers, ergot alkaloids, alpha-blockers, sympatholytics, ganglioblockers), with strophanthin, a sharp increase in their action is possible.
special instructions
It is used with caution in labile blood pressure. It is used with caution along with antihypertensive drugs. Effects on the ability to drive vehicles and control mechanismsWith special care to be used in drivers of vehicles, as well as in patients engaged in potentially hazardous activities.