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Active ingredients
Alclomethasone
Release form
Cream
Composition
Alklomethasone dipropionate 500 mcg. Adjuvants: propylene glycol, chlorocresol, sodium dihydrophosphate dihydrate, phosphoric acid, cetostearyl alcohol (cetyl alcohol 60%, steglyl alcohol 40%), macrogola cetostearate, macrogra, clyceral, and cetraltele;
Pharmacological effect
Non-fluorinated synthetic GCS for external use. It has anti-inflammatory, antiallergic, antipruritic and anti-proliferative effects. When applied to the skin in the inflammation, it quickly and effectively reduces the severity of objective symptoms (erythema, edema, lichenification) and subjective sensations (itching, irritation, pain).
Pharmacokinetics
Data on the pharmacokinetics of the drug Afloderm not provided.
Indications
Dermatoses, in which topical therapy of GCS is effective (including with localization on the skin of the face and in the anogenital area): - atopic dermatitis; - eczema; - psoriasis; - allergic and contact dermatitis; - solar dermatitis; - allergic reactions to bites insects. The drug can be used in children from 6 months.
Contraindications
- skin tuberculosis; - skin manifestations of syphilis; - chicken pox; - viral infections of the skin; - skin post-vaccination reactions; - open wounds; - trophic ulcers; - rosacea; - acne vulgaris; - hypersensitivity to alklomethasone or to any of the auxiliary components of the preparation .
Precautionary measures
Use in children. The drug can be used in young children. It should be noted that in young children skin folds and diapers can have an effect similar to the effect of an occlusive dressing, and increase, respectively, the systemic absorption of the active substance. In addition, children may have a greater degree of systemic absorption due to the ratio between the surface of the skin and body weight, as well as due to insufficient maturity of the epidermis. Therefore, long-term use in young children is possible only under the supervision of a physician.
Use during pregnancy and lactation
The use of Afloderm during pregnancy is possible only when the intended benefit to the mother outweighs the potential risk to the fetus.In such cases, the use of the drug should be short and limited to a small area of skin. There is no data on the teratogenic effect of the drug. It is possible to use Afloderm during lactation, but with caution, in particular, the drug should not be applied to the skin of the breast before feeding.
Dosage and administration
The cream is recommended to be used for the treatment of acute, incl. weeping skin lesions; ointment - for the treatment of sub-acute and chronic dermatoses, incl. dry, lichenized and flaky lesions, or in cases where an occlusive action of the ointment is necessary. Cream or ointment is evenly applied with a thin layer to the affected skin 2-3 times / day. On areas with denser skin (for example, elbows, palms and feet), as well as the places from which the drug is easily erased, Afloderm should be applied more often. In children and during the subsidence of the main symptoms, the drug can be used 1 time / day. To prevent a relapse treatment of chronic diseases therapy should continue for some time after the disappearance of all symptoms.
Side effects
Side effects from topical use of alclomethasone are rare and reversible. Dermatological reactions: 1–2% of patients may develop itching, burning, redness or dryness of the skin, irritation, papular rash; extremely rarely - acne-like changes, hypopigmentation, prickly heat, folliculitis, striae, skin atrophy, hypertrichosis, allergic contact dermatitis, secondary infections of the skin.
Overdose
Data on drug overdose Afloderm not provided.
Interaction with other drugs
There is no established clinically significant drug interaction Afloderm with other drugs.
special instructions
If at the first use of Afloderm hypersensitivity reactions develop (itching, burning and redness), the drug should be discontinued. Afloderm should not be applied to the skin in the eye area (due to the possible development of glaucoma and cataracts), as well as on open wound surfaces If the course of the disease is complicated by the development of a secondary bacterial or fungal infection, a specific antibacterial or antimycotic agent must be added to the treatment with Afloderm. Use in pediatrics The preparation can be in young children. It should be noted that in young children, skin folds and diapers can have an effect similar to that of an occlusive dressing, and increase, respectively,systemic absorption of the active substance. In addition, children may have a greater degree of systemic absorption due to the ratio between the surface of the skin and body weight, as well as due to insufficient maturity of the epidermis. Therefore, long-term use in young children is possible only under the supervision of a physician.