Artezine pills 2 mg 30 pcs
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Description
The composition of Doxazosin mesilate is 2.44 mg, in terms of doxazosin 2 mg. Excipients: potato starch, lactose, microcrystalline cellulose, povidone, colloidal silicon dioxide (aerosil), sodium lauryl sulfate (sodium dodecyl sulfate), magnesium stearate. Pharmacological action Selective competitive blocker of postsynaptic .1-adrenergic receptors. By reducing the muscle tone of the blood vessels, doxazosin reduces round-the-wall development, which leads to a decrease in blood pressure. After a single dose of the drug, the maximum decrease in blood pressure is noted within 2-6 hours. The hypotensive effect lasts for 24 hours. During the treatment period with Artezine. in patients with arterial hypertension, there are no differences in the values of blood pressure in the standing and lying positions. Effective with arterial hypertension, incl. accompanied by metabolic disorders (obesity, decreased glucose tolerance). Reduces the risk of developing CHD. The use of the drug in patients with normal blood pressure is not accompanied by a decrease in blood pressure. With prolonged use of Artezine in patients there is no decrease in the antihypertensive effect. During the treatment with Artezine, a decrease in the level of triglycerides and total cholesterol in the blood plasma is observed. At the same time, there is an increase (by 4-13%) in the HDL / total cholesterol ratio. With prolonged use of the drug, there is regression of left ventricular hypertrophy, suppression of platelet aggregation and an increase in the content of active plasminogen in the tissues. Due to the fact that doxazosin blocks .1-adrenergic receptors located in the stroma and capsule of the prostate gland and in the bladder neck, there is a decrease in resistance and pressure in the urethra, a decrease in the resistance of the internal sphincter, which in turn leads to a significant improvement in urodynamics and reduce the symptoms of benign prostatic hyperplasia. The drug is effective in 66-71% of patients, a stable clinical effect develops after 1-2 weeks of treatment, the maximum effect - after 14 weeks. The effect persists for a long time.
Dosage and administration
The drug is administered orally 1 time / day (in the morning or in the evening), regardless of the meal, without chewing and drinking plenty of water.In hypertension, the initial daily dose is 1 mg at bedtime. After taking the first dose, the patient should be in bed for 6-8 hours. This is necessary due to the possibility of the development of the "first dose phenomenon", especially against the background of previous diuretics. With a lack of therapeutic effect after 1-2 weeks, the daily dose can be increased to 2 mg. Subsequently, every 1-2 weeks, you can increase the dose by 2 mg. In most patients, the optimal therapeutic effect is achieved with a daily dose of 8 mg. The maximum daily dose is 16 mg. After reaching a stable therapeutic effect, the dose is usually reduced (the average therapeutic dose with maintenance therapy is usually 2-4 mg / day). With benign prostatic hyperplasia Artezine. prescribed in an initial dose of 1 mg / day in order to minimize the possibility of orthostatic hypotension and / or syncope. If necessary, depending on the indicators of urodynamics and the presence of symptoms of BPH, the dose is increased (with an interval of 1-2 weeks) to 2-4 mg / day. The maximum daily dose is 8 mg. The recommended maintenance dose is 2-4 mg / day. The drug is used for a long time. The duration of treatment is determined by the attending physician. Precautions During the period of treatment may worsen psoriasis. With pheochromocytoma, propranolol can be used only after taking an alpha blocker. After a long course of treatment, propranolol should be discontinued gradually, under the supervision of a physician. Against the background of treatment with propranolol, IV administration of verapamil, diltiazem should be avoided. A few days before anesthesia, you must stop taking propranolol or pick up a remedy for anesthesia with minimal negative inotropic effects. Influence on the ability to drive vehicles and control mechanisms In patients whose activities require increased attention, the question of the use of propranolol on an outpatient basis should be addressed only after evaluating the individual response of the patient. Side Effects Arterial Hypertension In clinical studies, orthostatic hypotension was most often observed, especially at the beginning of treatment, which in rare cases can lead to syncope. Since the cardiovascular system: peripheral edema, syncope.From the side of the central nervous system and peripheral nervous system: dizziness, headache, drowsiness. On the part of the digestive system: nausea. On the part of the respiratory system: rhinitis. Allergic reactions: skin rash, urticaria. General reactions: asthenia, fatigue, malaise. The following side effects were also noted in patients with arterial hypertension (the causal relationship with taking the drug has not been established): bradycardia, tachycardia, palpitations, chest pain, angina, myocardial infarction, impaired cerebral circulation, arrhythmia. Benign prostatic hyperplasia In patients with benign prostatic hyperplasia, the same side effects as in patients with arterial hypertension, as well as: From the side of the cardiovascular system: decrease in blood pressure, orthostatic hypertension. On the part of the central nervous system and peripheral nervous system: dry mouth, priapism, hypesthesia, paresthesia, tremor, impotence, insomnia, irritability. On the part of the endocrine system: gynecomastia. On the part of the digestive system: abdominal pain, constipation, diarrhea, dyspepsia, flatulence, loss of appetite, nausea, increased activity of hepatic transaminases, cholestasis, jaundice, hepatitis. From the side of blood-forming organs: leukopenia, purpura, thrombocytopenia. On the part of the musculoskeletal system: arthralgia, muscle cramps, muscle weakness, myalgia. On the part of the respiratory system: bronchospasm, cough, shortness of breath, nosebleeds. Dermatological reactions: alopecia. From the senses: blurred vision, tinnitus. On the part of the urinary system: dysuria, hematuria, urinary disturbance, nocturia, polyuria, urinary incontinence. Allergic reactions: skin rash, urticaria. Others: back pain, heat sensation (flushing in the skin of the face), weight gain. Cautions Special caution should be exercised in the appointment of the drug to patients with impaired liver function, especially in cases where at the same time used drugs that can adversely affect liver function. In cases of deterioration of the functional status of the liver, the drug should be canceled.In order to prevent orthostatic reactions, patients should avoid unexpected and abrupt changes in body position (moving from a prone position to a standing position). Caution should be exercised when used simultaneously with phosphodiesterase inhibitors (agents for treating erectile dysfunction), since in some patients this can lead to symptomatic hypotension. The effect of the "first dose" is especially pronounced in the background of previous diuretic therapy and a sodium restricted diet. Before starting treatment, it is necessary to exclude malignant tumors of the prostate gland. Influence on the ability to drive vehicles and control mechanisms Due to the fact that the drug is able to cause orthostatic reactions at the beginning of treatment or during the period of increasing doses, it is advisable for patients to refrain from all potentially dangerous activities, in particular from driving vehicles and other vehicles and mechanisms . Taking alcohol can increase undesirable reactions. Use during pregnancy and breastfeeding. So far, experience with the use of the drug Artezine. during pregnancy and during breastfeeding in patients with arterial hypertension is not enough. Therefore, despite the absence of teratogenic and embryotoxic effects according to experimental studies, Artezine. It can be prescribed during pregnancy and during breastfeeding only after a careful assessment of the expected benefits of therapy for the mother and the possible risk to the fetus or infant. Type: Drug Quantity in the package, pcs: 30 Shelf life: 36 months Active ingredient: Doxazosin (Doxazosin) Route of administration: Oral Vacation order: Prescription Release form: Prescription Storage conditions: In a dry place, In a dark place, Keep out of reach of children Maximum storage temperature, ° С: 25 Pharmacological group: C02CA04 Doxazosin Minimum age: 18 yearsActive ingredients
Release form
Pills
Composition
Doxazosin mesilate 2.44 mg, in terms of doxazosin 2 mg. Excipients: potato starch, lactose, microcrystalline cellulose, povidone, colloidal silicon dioxide (aerosil), sodium lauryl sulfate (sodium dodecyl sulfate), magnesium stearate.
Pharmacological effect
Selective competitive blocker postsynaptic & # 945 .1-adrenergic receptors. By reducing the muscle tone of the blood vessels, doxazosin reduces round-the-wall development, which leads to a decrease in blood pressure. After a single dose of the drug, the maximum decrease in blood pressure is noted within 2-6 hours. The hypotensive effect lasts for 24 hours. During the treatment period with Artezine. in patients with arterial hypertension, there are no differences in the values of blood pressure in the standing and lying positions. Effective with arterial hypertension, incl. accompanied by metabolic disorders (obesity, decreased glucose tolerance). Reduces the risk of developing CHD. The use of the drug in patients with normal blood pressure is not accompanied by a decrease in blood pressure. With prolonged use of Artezine in patients there is no decrease in the antihypertensive effect. During the treatment with Artezine, a decrease in the level of triglycerides and total cholesterol in the blood plasma is observed. At the same time, there is an increase (by 4-13%) in the HDL / total cholesterol ratio. With prolonged use of the drug, there is regression of left ventricular hypertrophy, suppression of platelet aggregation and an increase in the content of active plasminogen in the tissues. Due to the fact that doxazosin blocks & # 945 .1-adrenergic receptors located in the stroma and capsule of the prostate gland and in the bladder neck, there is a decrease in resistance and pressure in the urethra, a decrease in the resistance of the internal sphincter, which in turn leads to significant improving urodynamics and reducing the symptoms of benign prostatic hyperplasia. The drug is effective in 66-71% of patients, a stable clinical effect develops after 1-2 weeks of treatment, the maximum effect - after 14 weeks. The effect persists for a long time.
Indications
- arterial hypertension (in combination with other antihypertensive drugs: thiazide diuretics, beta-blockers, slow calcium channel blockers or ACE inhibitors). - benign prostatic hyperplasia (both in the presence of arterial hypertension and in normal blood pressure).
Contraindications
- age up to 18 years (efficacy and safety have not been established). - Hypersensitivity to doxazosin, a derivative of quinazolone or other components of the drug. With caution should use the drug for aortic and mitral stenosis, orthostatic hypotension, abnormal liver function.
Use during pregnancy and lactation
To date, experience with the drug Artezine. during pregnancy and during breastfeeding in patients with arterial hypertension is not enough. Therefore, despite the absence of teratogenic and embryotoxic effects according to experimental studies, Artezine. It can be prescribed during pregnancy and during breastfeeding only after a careful assessment of the expected benefits of therapy for the mother and the possible risk to the fetus or infant.
Dosage and administration
The drug is prescribed by mouth 1 time / day (in the morning or in the evening), regardless of the meal, without chewing and drinking plenty of water. In hypertension, the initial daily dose is 1 mg at bedtime. After taking the first dose, the patient should be in bed for 6-8 hours. This is necessary due to the possibility of the development of the "first dose phenomenon", especially against the background of previous diuretics. With a lack of therapeutic effect after 1-2 weeks, the daily dose can be increased to 2 mg. Subsequently, every 1-2 weeks, you can increase the dose by 2 mg. In most patients, the optimal therapeutic effect is achieved with a daily dose of 8 mg. The maximum daily dose is 16 mg. After reaching a stable therapeutic effect, the dose is usually reduced (the average therapeutic dose with maintenance therapy is usually 2-4 mg / day). With benign prostatic hyperplasia Artezine. prescribed in an initial dose of 1 mg / day in order to minimize the possibility of orthostatic hypotension and / or syncope. If necessary, depending on the indicators of urodynamics and the presence of symptoms of BPH, the dose is increased (with an interval of 1-2 weeks) to 2-4 mg / day. The maximum daily dose is 8 mg. The recommended maintenance dose is 2-4 mg / day. The drug is used for a long time. The duration of treatment is determined by the attending physician.
Side effects
Arterial hypertension In clinical studies, orthostatic hypotension was most often observed, especially at the beginning of treatment, which in rare cases can lead to syncope. Since the cardiovascular system: peripheral edema, syncope. From the side of the central nervous system and peripheral nervous system: dizziness, headache, drowsiness.On the part of the digestive system: nausea. On the part of the respiratory system: rhinitis. Allergic reactions: skin rash, urticaria. General reactions: asthenia, fatigue, malaise. The following side effects were also noted in patients with arterial hypertension (the causal relationship with taking the drug has not been established): bradycardia, tachycardia, palpitations, chest pain, angina, myocardial infarction, impaired cerebral circulation, arrhythmia. Benign prostatic hyperplasia In patients with benign prostatic hyperplasia, the same side effects as in patients with arterial hypertension, as well as: From the side of the cardiovascular system: decrease in blood pressure, orthostatic hypertension. On the part of the central nervous system and peripheral nervous system: dry mouth, priapism, hypesthesia, paresthesia, tremor, impotence, insomnia, irritability. On the part of the endocrine system: gynecomastia. On the part of the digestive system: abdominal pain, constipation, diarrhea, dyspepsia, flatulence, loss of appetite, nausea, increased activity of hepatic transaminases, cholestasis, jaundice, hepatitis. From the side of blood-forming organs: leukopenia, purpura, thrombocytopenia. On the part of the musculoskeletal system: arthralgia, muscle cramps, muscle weakness, myalgia. On the part of the respiratory system: bronchospasm, cough, shortness of breath, nosebleeds. Dermatological reactions: alopecia. From the senses: blurred vision, tinnitus. On the part of the urinary system: dysuria, hematuria, urinary disturbance, nocturia, polyuria, urinary incontinence. Allergic reactions: skin rash, urticaria. Others: back pain, heat sensation (flushing in the skin of the face), weight gain.
special instructions
Arterial hypertension In clinical studies, orthostatic hypotension was most often observed, especially at the beginning of treatment, which in rare cases can lead to syncope. Since the cardiovascular system: peripheral edema, syncope. From the side of the central nervous system and peripheral nervous system: dizziness, headache, drowsiness. On the part of the digestive system: nausea. On the part of the respiratory system: rhinitis. Allergic reactions: skin rash, urticaria.General reactions: asthenia, fatigue, malaise. The following side effects were also noted in patients with arterial hypertension (the causal relationship with taking the drug has not been established): bradycardia, tachycardia, palpitations, chest pain, angina, myocardial infarction, impaired cerebral circulation, arrhythmia. Benign prostatic hyperplasia In patients with benign prostatic hyperplasia, the same side effects as in patients with arterial hypertension, as well as: From the side of the cardiovascular system: decrease in blood pressure, orthostatic hypertension. On the part of the central nervous system and peripheral nervous system: dry mouth, priapism, hypesthesia, paresthesia, tremor, impotence, insomnia, irritability. On the part of the endocrine system: gynecomastia. On the part of the digestive system: abdominal pain, constipation, diarrhea, dyspepsia, flatulence, loss of appetite, nausea, increased activity of hepatic transaminases, cholestasis, jaundice, hepatitis. From the side of blood-forming organs: leukopenia, purpura, thrombocytopenia. On the part of the musculoskeletal system: arthralgia, muscle cramps, muscle weakness, myalgia. On the part of the respiratory system: bronchospasm, cough, shortness of breath, nosebleeds. Dermatological reactions: alopecia. From the senses: blurred vision, tinnitus. On the part of the urinary system: dysuria, hematuria, urinary disturbance, nocturia, polyuria, urinary incontinence. Allergic reactions: skin rash, urticaria. Others: back pain, heat sensation (flushing in the skin of the face), weight gain.