Ascoril Expectorant Syrup 100 ml
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Active ingredients
Bromhexine + Guaifenezin + Salbutamol + Racemore
Release form
Syrup
Composition
Active ingredient: Salbutamol Sulfate 20 mg, Bromhexine hydrochloride 40 mg, Guaifenesin 1g, Menthol 10 mg. Concentration of active ingredient (mg): 71 mg
Pharmacological effect
Pharmacological action - expectorant, mucolytic, bronchodilator.
Pharmacokinetics
Salbutamol: When ingested, absorption is high. Eating reduces the rate of absorption, but does not affect bioavailability. Communication with plasma proteins - 10%. Penetrates through the placenta. Subjected to presystemic metabolism in the liver and intestinal wall, is inactivated by phenol sulfotransferase to 4-o-sulfate ester. T1 / 2 - 3.8–6 hours. Excreted by the kidneys (69–90%), mainly as an inactive phenolsulfate metabolite (60%) for 72 hours and with bile (4%). The bioavailability of orally administered salbutamol is about 50%. Bromhexine: When administered orally, almost completely (99%) is absorbed in the gastrointestinal tract within 30 minutes. Bioavailability is low (the effect of the primary passage through the liver). It penetrates the placental barrier and the BBB. In the liver it undergoes demethylation and oxidation, it is metabolized to pharmacologically active ambroxol. T1 / 2 - 15 h (due to slow reverse diffusion from tissues). Excreted by the kidneys. When CRF disrupts metabolism. With repeated use may accumulate. Gvayfenezin: Absorption from the gastrointestinal tract is fast (25–30 minutes after ingestion). T1 / 2 - 1 h. Penetrates tissues containing acid mucopolysaccharides. Approximately 60% of the administered drug is metabolized in the liver. It is excreted by the lungs (with sputum) and kidneys, both unchanged and in the form of inactive metabolites.
Indications
Acute and chronic (in the acute stage) respiratory diseases accompanied by coughing or broncho-obstruction, such as: bronchitis (including with obstruction), bronchial asthma, pneumonia, whooping cough and paracaute, tracheobronchitis, pulmonary tuberculosis.
Contraindications
Intolerance to active or auxiliary substances of the drug. Diseases of the cardiovascular system: arrhythmias, myocarditis, aortic stenosis, arterial hypertension. Endocrine pathologies: hyperthyroidism, decompensated diabetes.Other pathologies: glaucoma, peptic ulcer of the stomach or duodenum in the acute stage.
Precautionary measures
It should be carefully taken Ascoril patients with hyperthyroidism, diabetes, severe diseases of the cardiovascular system, arterial hypertension, gastric ulcer and duodenal ulcer.
Use during pregnancy and lactation
During pregnancy, the drug is not recommended. If necessary, drug treatment during lactation breastfeeding should be discontinued.
Dosage and administration
The average therapeutic dosage recommended for adults is 10 ml of Ascoril three times a day, but can be increased if necessary. Ascoril is prescribed to children depending on age: Ascoril is recommended to be taken up to 6 years old, at a dose of 5 ml three times a day, to children from 6 to 12 years old, 5-10 ml three times a day, depending on the clinical picture.
Side effects
Symptoms of CNS arousal: tremor, sleep disturbance, convulsions, headache, nervous irritability. On the part of the digestive system: the phenomenon of dyspepsia, exacerbation of peptic ulcer, changes in liver samples Since the cardiovascular system: lower blood pressure, sometimes up to collapse, increased heart rate. Others: allergic reactions, discoloration of the urine, paradoxical bronchospasm.
Overdose
Symptoms: increased manifestations of side effects. Treatment: symptomatic therapy.
Interaction with other drugs
Other beta2-adrenomimetic agents and theophylline increase the effects of salbutamol and increase the likelihood of side effects. Ascoril is not prescribed simultaneously with drugs containing codeine, and other antitussive drugs, since this makes it difficult to discharge liquefied sputum. Ascoril Bromhexine, which is part of the preparation, promotes the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline) into the lung tissue. It is not recommended to use the drug Ascoril concurrently with non-selective beta-adrenergic receptor blockers, such as propranolol. Part of the drug Ascoril salbutamol is not recommended for patients who receive MAO inhibitors. Diuretics and drugs GKS enhance the hypokalemic effect of salbutamol.It is not recommended to take along with the drug Ascoril alkaline drink.
special instructions
It should be carefully taken Ascoril patients with hyperthyroidism, diabetes, severe diseases of the cardiovascular system, arterial hypertension, gastric ulcer and duodenal ulcer.