Acecardol pills intestinal.ob. 300mg N30
Condition: New product
1000 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Acetylsalicylic acid
Release form
Pills
Composition
1 tab. acetylsalicylic acid 300 mg. Excipients: low molecular weight povidone - 19.
Pharmacological effect
The mechanism of the antiplatelet action of acetylsalicylic acid (ASK) is based on the irreversible inhibition of cyclooxygenase (COX-1), as a result of which thromboxane A2 synthesis is blocked and platelet aggregation is inhibited. Antiplatelet effect develops even after the use of small doses of the drug and persists for 7 days after a single dose. It is believed that ASA has other mechanisms for the suppression of platelet aggregation. In high doses, ASA (over 300 mg / day) also has anti-inflammatory, antipyretic and analgesic effects.
Indications
- prevention of acute myocardial infarction in the presence of risk factors (for example, diabetes, hyperlipidemia, arterial hypertension, obesity, smoking, old age) - prevention of recurrent myocardial infarction - unstable stenocardia - prevention of ischemic stroke (including in patients with transient disorder cerebral circulation) - prevention of thromboembolism after operations and invasive interventions on the vessels (for example, coronary artery bypass surgery, carotid artery endarterectomy, arteriovenous bypass surgery , angioplasty and stenting of coronary arteries, angioplasty of the carotid arteries) - prevention of deep vein thrombosis and pulmonary embolism and its branches (including with prolonged immobilization as a result of extensive surgical intervention).
Contraindications
- erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase) - gastrointestinal bleeding - hemorrhagic diathesis - bronchial asthma, induced by salicylate intake, complete or incomplete combination of bronchial asthma, recurrent polyposis of the nasal sinus and nasal sinus and AOS, tolerance of the ASC - pronounced heart failure, pronounced heart disease, recurrent polyposis of the nose and the paranasal sinuses and AIC, - a patient with an acute respiratory syndrome - a pronounced heart rate, recurrent nasal polyposis and nasal mucosa and SARS - a pronounced heart failure, a pronounced heart rate, an acute respiratory distress syndrome, recurrent nasal polyposis and nasal sinusitis and nasal inflammation of the acetabulum; (CC) less than 30 ml / min) - severe liver failure (class B and C on the Child-Pugh scale) - chronic heart failure (III-IV functional class according to the NYHA classification) - dnovremenny methotrexate at a dose of 15 mg / week or more - I and III trimester of pregnancy - lactation - children up to 18 years - the lactase deficiency, lactose intolerance, glucose-galactose malabsorption - hypersensitivity to ASA. With caution in: - gout, hyperuricemia, becauseLow-dose ASA reduces the excretion of uric acid. It should be borne in mind that low-dose ASA may trigger the development of gout in susceptible patients (with reduced excretion of uric acid) - gastric ulcer and duodenal ulcer or gastrointestinal bleeding (in history) - impaired function liver (class A on a Child-Pugh scale) - renal dysfunction (CC more than 30 ml / min) - bronchial asthma, chronic diseases of the respiratory system, hay fever, nasal polyposis, drug allergy - od modern administration of methotrexate in a dose of less than 15 mg / week — concomitant therapy with anticoagulants — II trimester of pregnancy — proposed surgery (including small, for example, tooth extraction), since ASK may cause a tendency to develop bleeding for several days after taking the drug.
Use during pregnancy and lactation
The use of salicylates in large doses in the first 3 months of pregnancy is associated with an increased frequency of fetal developmental defects (split palate, heart defects). The appointment of salicylates in the first trimester of pregnancy is contraindicated. In the II trimester of pregnancy, salicylates can be prescribed only with a rigorous assessment of the risk to the fetus and benefit to the mother, preferably in doses not higher than 150 mg / day and not for long. In the third trimester of pregnancy, salicylates at a high dose (more than 300 mg / day) cause a weakening of labor, premature closure of the ductus arteriosus in the fetus, increased bleeding in the mother and fetus, and administration directly to the birth can cause intracranial hemorrhages, especially in premature babies. The appointment of salicylates in the III trimester of pregnancy is contraindicated. Salicylates and their metabolites in small quantities penetrate into breast milk, so breastfeeding should be abolished during lactation.
Side effects
On the part of the digestive system: nausea, heartburn, vomiting, abdominal pain. ulcers of the mucous membrane of the stomach and duodenum. perforated ulcers of the stomach and duodenum, gastrointestinal bleeding, transient abnormal liver function with increased activity of hepatic transaminases.On the part of the hematopoietic system: the appointment of ASA is accompanied by an increased risk of bleeding due to the inhibitory effect of ASA on platelet aggregation, anemia. Allergic reactions: skin rash, pruritus, urticaria, angioedema, rhinitis, swelling of the nasal mucosa, cardiorespiratory distress syndrome, and severe reactions, including anaphylactic shock. On the part of the respiratory system: bronchospasm. From the side of the central nervous system: dizziness, hearing loss, headache, tinnitus.
special instructions
On the part of the digestive system: nausea, heartburn, vomiting, abdominal pain. ulcers of the mucous membrane of the stomach and duodenum. perforated ulcers of the stomach and duodenum, gastrointestinal bleeding, transient abnormal liver function with increased activity of hepatic transaminases. On the part of the hematopoietic system: the appointment of ASA is accompanied by an increased risk of bleeding due to the inhibitory effect of ASA on platelet aggregation, anemia. Allergic reactions: skin rash, pruritus, urticaria, angioedema, rhinitis, swelling of the nasal mucosa, cardiorespiratory distress syndrome, and severe reactions, including anaphylactic shock. On the part of the respiratory system: bronchospasm. From the side of the central nervous system: dizziness, hearing loss, headache, tinnitus.