Cavinton concentrate for infusions 5mg 1ml 10ml ampoules N5
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Description
Colorless or slightly greenish transparent solution for infusions Cavinton improves brain metabolism, increasing the consumption of glucose and oxygen by the brain tissue. Increases the resistance of neurons to hypoxia, enhancing glucose transport to the brain through the blood-brain barrier translates the decay of glucose energetically economical, aerobic path selectively blocked Ca2 + / dependent phosphodiesterase (PDE), improves levels of adenosine monophosphate (AMP) and cyclic guanosine monophosphate (cGMP ) brain. It increases the concentration of ATP in brain tissue, increases the metabolism of norepinephrine and serotonin in the brain, stimulates the ascending branch of the noradrenergic system, and has an antioxidant effect. It reduces platelet aggregation and increased blood viscosity, increases the deforming ability of red blood cells and blocks the utilization of adenosine by red blood cells, and contributes to an increase in oxygen yield by red blood cells. Enhances the neuroprotective effect of adenosine. Increases cerebral blood flow, reduces the resistance of cerebral vessels without significant changes in the systemic circulation (blood pressure, minute volume, heart rate, general peripheral resistance). Not only does not have the effect of "robbing", but also enhances the blood supply, especially in ischemic brain regions with low perfusion.
Active ingredients
Vinpocetine
Composition
Vinpocetin, ascorbic acid, sodium disulfite, tartaric acid, benzene alcohol, sorbitol, water for injection.
Indications
Neurology: a decrease in the severity of neurological and psychiatric symptoms in various forms of circulatory insufficiency of the brain (ischemic stroke, non-surgical cerebral disease) Ophthalmology: chronic vascular diseases of the choroid and retina (for example, thrombosis (occlusion) of the central artery or vein of the retina).For the treatment of perceptual type hearing loss, Meniere's disease, idiopathic tinnitus.
Use during pregnancy and lactation
Contraindicated in pregnancy and lactation.
Dosage and administration
The drug is intended for intravenous drip infusion, administered slowly (infusion rate should not exceed 80 drops / min)! It is forbidden to enter intramuscularly and intravenously without dilution! To prepare the infusion, you can use saline or solutions containing dextrose (Salsol, Ringer, Index, Reomacrodex). Infusion solution with Cavinton should be used in the first 3 hours after preparation. The usual initial daily dose: 20 mg (2 amp.) In 500 ml of infusion solution. Depending on tolerance, within 2-3 days the dose can be increased to no more than 1 mg / kg / day. The average duration of treatment is 10-14 days. The average daily dose with a body weight of 70 kg - 50 mg (5 amp. In 500 ml of infusion solution). In diseases of the liver and kidneys, dose adjustment is not required.
Side effects
Side effects against the use of the drug were rarely detected. Since the cardiovascular system: ECG changes (ST depression, prolongation of the QT interval), tachycardia, extrasystole, however, the presence of a causal connection has not been proven because in the natural population, these symptoms are observed with the same frequency, a change in blood pressure (often a decrease), reddening of the skin, phlebitis. On the part of the central nervous system: sleep disturbances (insomnia, increased drowsiness), dizziness, headache, general weakness (these symptoms may be manifestations of the underlying disease). On the part of the digestive system: dry mouth, nausea, heartburn. Other: allergic skin reactions, increased sweating.
Overdose
Treatment with overdose: gastric lavage, taking activated carbon, symptomatic therapy.
Interaction with other drugs
No interaction was observed with simultaneous use with β-blockers (chloranolol, pindolol), clopamide, glibenclamide, digoxin, acenocoumarol or hydrochlorothiazide. In rare cases, the simultaneous use of a-methyl-dopa is accompanied by a slight increase in the anti-hypertensive effect, and the use of this combination requires regular monitoring of blood pressure.Despite the lack of data confirming the possibility of interaction, it is recommended that caution be exercised while simultaneously prescribing with drugs of the central nervous, anti-arrhythmic action. Cavinton's concentrate for preparing the solution for infusions and heparin are chemically incompatible, therefore it is prohibited to administer them in the same infusion mixture, however, it is possible to simultaneously treat with anticoagulants and vinpocetine. Cavinton concentrate for preparing an infusion solution is incompatible with infusion solutions containing an amino acid, so they cannot be used to dilute Cavinton.
special instructions
The presence of prolonged QT syndrome and the use of drugs that cause prolongation of the QT interval require periodic ECG monitoring. Cavinton infusion solution contains sorbitol (160 mg / 2 ml), therefore, in the presence of diabetes, it is necessary to periodically monitor blood sugar levels. In the case of fructose intolerance or deficiency of fructose 1,6-diphosphatase, the use of vinpocetine should be avoided.