Chlorprothixene coated pills 15mg N50
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Active ingredients
Chlorprothixen
Release form
Pills
Composition
1 tab. Chlorprothixene hydrochloride 15 mg. Excipients: corn starch - 10 mg, lactose monohydrate - 92 mg, sucrose - 10 mg, calcium stearate - 1.
Pharmacological effect
Antipsychotic (neuroleptic), a derivative of thioxanthene. It has antipsychotic, antidepressant, sedative, antiemetic effects, has alpha-adreno-blocking activity. It is believed that the antipsychotic effect is associated with the blockade of postsynaptic dopamine receptors in the brain. The antiemetic effect is associated with blockade of the chemoreceptor trigger zone of the medulla oblongata. The sedative effect is due to the indirect weakening of the activity of the reticular system of the brain stem. Suppresses the release of most hormones of the hypothalamus and pituitary gland. However, as a result of blockade of the prolactin inhibitory factor, which inhibits the release of prolactin from the pituitary, the concentration of prolactin increases. The chemical structure and pharmacological properties of thioxanthenes are similar to piperazine derivatives of phenothiazine.
Pharmacokinetics
Metabolized in the liver. Excreted mainly by the kidneys.
Indications
Psychoses and psychotic states accompanied by anxiety, fear, psychomotor agitation, aggressiveness, incl. in depressive-paranoid, circular schizophrenia, in simple, slow-moving schizophrenia with psychopathic and neurosis-like symptoms and in other mental diseases, dyscirculatory encephalopathy, traumatic brain injury (as part of a combination therapy), alcoholic delirium, sleep disorders in somatic diseases, the need for long treatment , psychosomatic, neurotic and behavioral disorders in children, convulsive cough, spastic states in the gastrointestinal tract premedication ermatozy accompanied persistent itch allergic reactions.
Contraindications
CNS depression, incl. with alcohol intoxication, barbiturates and other drugs that have a depressant effect on the central nervous system, pathological changes in the blood picture, myelodepression, pregnancy, lactation, hypersensitivity to chlorprotixen.
Use during pregnancy and lactation
Contraindicated for use during pregnancy and lactation.
Dosage and administration
Individual. For oral administration for adults, the daily dose varies from 10 mg to 600 mg, for children from 5 mg to 200 mg. The frequency of treatment and the duration of treatment are determined by indications.
Side effects
From the side of the central nervous system: possible psychomotor inhibition, mild extrapyramidal syndrome, fatigue, dizziness; in isolated cases, paradoxical increased anxiety is possible, especially in patients with mania or schizophrenia. On the part of the digestive system: cholestatic jaundice is possible. Since the cardiovascular system: possible tachycardia, changes in the ECG, orthostatic hypotension. On the part of the organ of vision: possible clouding of the cornea and lens with visual impairment. From the hematopoietic system: agranulocytosis, leukocytosis, leukopenia, hemolytic anemia are possible. On the part of the endocrine system: frequent flushes, amenorrhea, galactorrhea, gynecomastia, weakening of potency and libido are possible. On the part of metabolism: possible increased sweating, impaired carbohydrate metabolism, increased appetite with weight gain. Dermatological reactions: photosensitivity, photodermatitis are possible. Effects caused by anticholinergic effects: dry mouth, constipation, accommodation disturbances, dysuria.
Interaction with other drugs
With simultaneous use with anesthetics, opioid analgesics, sedatives, hypnotics, antipsychotics, with ethanol, ethanol-containing drugs increases the inhibitory effect on the central nervous system. With simultaneous use with antihypertensive agents hypotensive effect is enhanced. With simultaneous use with anticholinergic, antihistamine, antiparkinsonic drugs increases the anticholinergic effect. With simultaneous use with agents that cause extrapyramidal reactions, it is possible to increase the frequency and severity of extrapyramidal reactions; with levodopa - suppression of anti-parkinsonian action of levodopa is possible; with lithium carbonate - pronounced extrapyramidal symptoms, neurotoxic effect.With simultaneous use with epinephrine, blockade of the alpha adrenergic effects of epinephrine and the development of severe arterial hypotension and tachycardia as a result of this is possible. With simultaneous use with phenothiazines, metoclopramide, haloperidol, reserpine, extrapyramidal disorders may develop; with quinidine - possibly strengthening the inhibitory effect on the heart.
special instructions
It should not be used for epilepsy, a tendency to collapse, parkinsonism, heart defects in the stage of decompensation, tachycardia, atherosclerosis of cerebral vessels, marked impaired liver function and kidney disorders, hematopoiesis, cachexia, in old age. If it is necessary to use Chlorprothixene, one should compare the risk and benefit of treatment in patients with chronic alcoholism, cardiovascular diseases (increased risk of transient arterial hypotension), Reye's syndrome, and also with glaucoma or susceptibility to it, gastric ulcer and duodenal ulcer, delayed urine, Parkinson’s disease, epileptic seizures, hypersensitivity to other thioxanthenes or phenothiazines. With the use of Chlorprothixene, false positive results of the immunological pregnancy test using urine are possible, as well as false positive results of the urine bilirubin test. During the period of treatment to prevent the use of alcohol. Influence on the ability to drive vehicles and control mechanisms During the period of treatment should refrain from engaging in potentially hazardous activities that require increased attention, quick psychomotor reactions.