Etamzilat injection solution 250mg 2ml ampoules 2ml N10
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Active ingredients
Etamzilat
Composition
Etamzilat 125 mg per 1 ml. Excipients: sodium disulfite, sodium sulfite anhydrous, disodium edetate, water d / and.
Pharmacological effect
Antihemorrhagic agent. Normalizes the permeability of the vascular wall, improves microcirculation. The action is apparently associated with an activating effect on the formation of thromboplastin. It does not affect the prothrombin time, does not have hypercoagulable properties and does not contribute to the formation of blood clots. The onset of action is 5–15 min after i / v injection, the maximum effect is 1–2 h after administration. Duration of action - 4-6 hours.
Pharmacokinetics
About 72% of the administered dose is excreted in the urine during the first 24 hours unchanged. T1 / 2 after the on / in the introduction of about 2 h. Penetrates the placental barrier, excreted in breast milk.
Indications
Prevention and treatment of capillary bleeding in diabetic angiopathies, during surgical interventions in otolaryngological practice, in ophthalmology, dentistry, urology, in surgery and gynecology; emergency cases with intestinal and pulmonary hemorrhages, with hemorrhagic diathesis.
Contraindications
Thrombosis, thromboembolism, hypersensitivity to etamzilat. Etamzilat can not be used as the only means in the presence of a patient with hemorrhages caused by anticoagulants.
Dosage and administration
When ingestion - 250-500 mg 3-4 times / day, in / m or in / in - 125-250 mg 3-4 times / day. If necessary, a single dose for oral administration can be increased to 750 mg, for parenteral administration to 375 mg. Children - 10-15 mg / kg / day, the multiplicity of use - 3 times / day in equal doses. When applied externally, a sterile tampon soaked in etamzilat (in the form of an injection) is placed on the wound.
Side effects
Heartburn, feeling of heaviness in the epigastric region, headache, dizziness, facial hyperemia, decrease in systolic blood pressure, lower limbs paresthesia are possible.
special instructions
Pharmaceutical incompatible with other drugs.