Fuzzitalmic eye drops 1% 5g
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Active ingredients
Fuzidovaya acid
Composition
1 g of the fusidic acid micronized (in terms of fusidic acid anhydrous) 10 mg (equivalent to 10.17 mg of fusidic acid hemihydrate). Excipients: benzalkonium chloride - 0.
Pharmacological effect
Antimicrobial drug, an antibiotic of a polycyclic structure, belongs to the group of fuzidin. The mechanism of action is associated with impaired protein synthesis in the bacterial cell. By blocking the elongation of factor g, it prevents its binding to ribosomes and guanosine triphosphate, which interrupts the release of the energy required for protein synthesis, and leads to the death of the bacterial cell. It is active against microorganisms that most often cause eye infections: Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae. Enterobacteriaciae and Pseudomonas spp. resistant to fusidic acid. There are no reports of cross-resistance to fusidic acid.
Pharmacokinetics
Absorption and distribution: Dosage form of the drug (viscous eye drops) ensures prolonged contact with the conjunctiva and a sufficient concentration of fusidic acid in the tear fluid provided it is used 2 times / day. After 1, 3, 6 and 12 hours after a single application of Fucithalmic, the average concentration of fusidic acid in the tear fluid is 15.7; 15.2; 10.5 and 5.6 mcg / ml, respectively. In intraocular fluid, the concentration of fusidic acid, equal to 0.3 μg / ml (after a single application) and 0.8 μg / ml (after repeated use), is reached within 1 h after application and maintained for at least 12 h, while fusidic serum acid is not detected. Excretion: Excreted mainly in the bile. Excretion in the urine is less than 1% of the dose.
Indications
Treatment of bacterial infections of the eyes caused by microorganisms sensitive to the drug: - conjunctivitis - blepharitis - keratitis - dacryocystitis.
Contraindications
- hypersensitivity to the drug.
Use during pregnancy and lactation
Perhaps the use of the drug Fucitalmik prescribed by the attending physician, if the expected therapeutic effect exceeds the potential risk of side effects in the fetus or child.
Dosage and administration
Adults and children from 0 years old are instilled 1 drop in the conjunctival sac of the affected eye 2 times / day for 7 days.
Side effects
Determination of the frequency of undesirable side reactions: very often (> 1/10), often (> 1/100, less than 1/10), infrequently (> 1/1000, less than 1/100), rarely (> 1/10 000, less 1/1000), very rarely (1/10 000, including individual messages). On the part of the organ of vision: the frequency is unknown - periorbital edema. Allergic reactions: frequency is unknown - itching, rash, urticaria, angioedema.
Overdose
No cases of drug overdose have been reported.
Interaction with other drugs
Data on drug interactions are not available.
special instructions
Prolonged use of an antimicrobial drug can lead to the development of superinfection caused by microorganisms resistant to this drug, including mushrooms. The tube must be closed after each use. Do not touch the tip of the tube to the eye. Therapy with Futsitalmik should be discontinued in case of symptoms of hypersensitivity to the drug. It is not recommended to wear contact lenses during the use of the drug Fucitalmik. Fusidic acid microcrystals can cause scratches on the lenses or the cornea. Impact on the ability to drive and work with mechanisms When a blurring of vision occurs after instillation, it is necessary to refrain from driving and engaging in potentially hazardous activities that require increased concentration of attention and psychomotor speed until vision is restored.