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Active ingredients
Ketoprofen
Release form
Gel
Composition
1 g of gel contains: Active substance: ketoprofen 25 mg. Auxiliary substances: (carbomer - 20 mg, trolamine (triethanolamine) - 37 mg, ethanol 96% - 285 mg, lavender oil (lavender essential oil) - 0.28 mg, water - 632.72 mg) - 1 g
Pharmacological effect
NSAIDs. It has analgesic, anti-inflammatory and anti-edema effect. Inhibits the activity of COX, which leads to inhibition of prostaglandin synthesis. In addition, ketoprofen inhibits lipoxygenase, the synthesis of bradykinin, stabilizes lysosomal membranes and prevents the release of enzymes involved in the inflammatory process. Ketoprofen does not adversely affect the condition of the articular cartilage.
Pharmacokinetics
Absorption Ketoprofen is absorbed very slowly and practically does not accumulate in the body. Bioavailability is 5%. Ketoprofen penetrates into the synovial fluid and reaches therapeutic concentrations there. The concentration of the drug in the blood plasma is extremely low. Metabolism and elimination of Ketoprofen is metabolized in the liver to form conjugates that are mainly excreted in the urine. Ketoprofen is characterized by slow urine excretion. The pharmacokinetics in special clinical situations of ketoprofen does not depend on the age, the degree of renal failure, or liver cirrhosis.
Contraindications
hypersensitivity to ketoprofen or other components of the drug, as well as salicylates or other nonsteroidal anti-inflammatory drugs; a history of attacks of asthma after the use of NSAIDs and salicylates; III trimester of pregnancy; children's age (up to 12 years), violation of the integrity of the skin (eczema, weeping dermatitis, open or infected wounds).
Use during pregnancy and lactation
The drug is contraindicated for use in the III trimester of pregnancy. Use in I and II trimesters is possible in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus. The use of the drug Ketonal during lactation (breastfeeding) is not recommended.
Dosage and administration
For external use. A small amount of gel (3–5 cm) is applied in a thin layer onto the skin of an inflamed or painful area of the body 1–2 times a day and gently rubbed. An occlusive dressing is not recommended. The dosage should be selected according to the area of the affected area: 5 cm Ketonal gel correspond to 100 mg ketoprofen,10 cm - 200 mg of ketoprofen. Ketonal gel can be used in combination with other dosage forms of Ketonal (capsules, pills, suppositories). The total daily dose regardless of the dosage form should not exceed 200 mg. Do not use more than 14 days without consulting a doctor.
Side effects
Infrequently - skin irritation, allergic skin reactions, hyperemia, itching, rash, burning sensation; rarely - edema, erythema, eczema, including vesicular, bullous and flaktenulnozno that can spread and acquire a generalized nature; purple-like, violent rash; increased sweating, urticaria, dermatitis (contact, exfoliative) photosensitivity, including serious skin reactions from exposure to the sun; purpura, erythema multiforme, dermatitis, resembles lichen, skin necrosis, Stevens-Johnson syndrome. There were reports of local skin reactions, in the future could go beyond the site of application of the drug.
Overdose
Symptoms: irritation, erythema, pruritus. Treatment: it is necessary to stop the use of the drug, rinse the skin thoroughly with running water. The patient needs to see a doctor.
Interaction with other drugs
Since the concentration of the drug in the blood plasma is extremely low, the manifestation of symptoms of interaction with other drugs (similar symptoms with systemic use) are possible only with frequent and prolonged use. Simultaneous use of other forms for topical and topical use (ointments, gels) containing ketoprofen or other NPSVs. Taking acetylsalicylic acid at the same time reduces ketoprofen binding to plasma proteins. Ketoprofen reduces methotrexate elimination and helps increase eniyu toksichnosti.Vzaimodeystvie it with other drugs and the impact of their elimination are not znachimymi.Patsientam taking kumarinsoderzhaschie anticoagulant drugs, are recommended treatment under medical supervision.
special instructions
Avoid getting the gel in the eyes, on the skin around the eyes, mucous membranes. If you experience any side effects, you must stop using the drug and consult a doctor. If the patient forgot to apply the gel, you should use it at the time when the next dose should be applied. , but not to double it. Ketonal gel for external use can be used in combination with other dosage forms of the drug Ketonal (capsules, pills, suppositories).The total daily dose, regardless of the dosage form, should not exceed 200 mg. In the event of skin reactions, including developed when combined with octocrylene-containing drugs, treatment should be discontinued immediately. To reduce the risk of photosensitivity, it is recommended to protect skin-treated areas with clothing from UVA exposure during the entire treatment period and for 2 more weeks after discontinuing the use of the gel. occlusive dressings. Hands should be thoroughly washed after each application of the preparation. The effect on the ability to drive vehicles and control mechanisms of data on the denial There is no effective influence of Ketonal gel on the ability to drive vehicles and other potentially dangerous activities requiring concentration of attention and speed of psychomotor reactions.