Ketosteril film-coated pills 50mg N100
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Active ingredients
Ketoanalogues of amino acids
Release form
Pills
Composition
Active ingredient: DL-methyl-oxo-2-calcium valerinate (α-ketoanalog isoleucine) 67 mg Concentration of active substance (mg.): 50mg
Pharmacological effect
Combined drug. Provides a complete supply of essential amino acids with minimal nitrogen intake. Ketone analogs of amino acids in the body are enzymatically transaminated into the corresponding L-amino acids, cleaving urea. The drug promotes the utilization of nitrogen-containing metabolic products, anabolism of proteins while reducing the concentration of urea in the serum. Improves nitrogen metabolism. Decreases the concentration of potassium, magnesium and phosphate ions in the blood. With the systematic use of the drug, an improvement in the condition of patients with chronic renal failure has been noted. In some cases, it is possible to delay the start of dialysis.
Pharmacokinetics
Data on the pharmacokinetics of the drug Ketosteril not provided.
Indications
protein-energy failure, prevention and treatment of disorders caused by altered protein metabolism in chronic renal failure and protein intake in the diet (in adults and children aged 3 years and older). For patients with a glomerular filtration rate less than 25 ml / min, which does not exclude use at a glomerular filtration rate of ≥25 ml / min.
Contraindications
hypercalcemia; disruption of amino acid metabolism; hypersensitivity to the components of the drug. In hereditary phenylketonuria, it should be borne in mind that the drug contains phenylalanine.
Precautionary measures
Do not exceed recommended doses.
Use during pregnancy and lactation
Clinical experience with Ketosteril during pregnancy and lactation is insufficient.
Dosage and administration
The drug is prescribed by mouth, as a rule, 3 times / day during meals. Tablets should be swallowed without chewing. Ketosteril is used during the entire period when the glomerular filtration rate is less than 25 ml / min. In the predialysis period, a protein content of no more than 40 g / day is recommended depending on the degree of chronic renal failure. being on dialysis, protein intake should comply with accepted recommendations. The recommended protein content in food for children 3-10 years old is 1.4-0.8 g / kg / day, for children over 10 years old - 1-0.6 g / kg / day.
Side effects
On the part of metabolism: in some cases, hypercalcemia may develop.
Overdose
Data overdose Ketosteril not provided.
Interaction with other drugs
With the simultaneous appointment of drugs containing calcium, it is possible to increase the level of calcium in the blood serum. As uremic symptoms diminish under the influence of Ketosteril, the dose of aluminum hydroxide used at the same time should be reduced accordingly. Follow the decrease in serum phosphate levels. intestine, should not be taken simultaneously with the drug Ketosteril drugs that form difficult soluble compounds with calcium (for example ep, tetracyclines, quinolones, preparations containing iron, fluoro and estramustine). Between taking the drug Ketosteril and similar drugs should be an interval of not less than 2 hours.
special instructions
When hypercalcemia is recommended to reduce the dose of taken vitamin D. If hypercalcemia persists, reduce the dose of Ketosteril, as well as other sources of calcium. Regular calcium should be monitored and serum phosphate levels should be reduced. Ketosteril should be taken with meals to improve its absorption and turning into the corresponding amino acids. It is necessary to ensure sufficient caloric content of food. In patients with hypersensitivity to the components of the drug in some cases, allergic reactions may occur.