Mexidol injection 50mg ml ampoule 2ml N10
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Active ingredients
Ethyl methyl hydroxypyridine succinate
Release form
Solution
Composition
Ethyl methyl hydroxypyridine succinate 50 mg / ml. Adjuvants: sodium metabisulfite - 0.4 mg, water d / and - up to 1 ml.
Pharmacological effect
Antioxidant drug. It has antihypoxic, membrane-protective, nootropic, anticonvulsant and anxiolytic effects, increases the body's resistance to stress. The drug increases the body's resistance to the effects of major damaging factors, to oxygen-dependent pathological conditions (shock, hypoxia and ischemia, cerebral circulation disorders, alcohol intoxication and antipsychotics / neuroleptics /). Mexidol improves brain metabolism and blood circulation of the brain, improves microcirculation and rheological properties of the blood , reduces platelet aggregation. Stabilizes membrane structures of blood cells (erythrocytes and platelets) during hemolysis. It has a hypolipidemic effect, reduces the level of total cholesterol and LDL. Reduces enzymatic toxemia and endogenous intoxication in acute pancreatitis. The mechanism of action of the drug Mexidol is due to its antihypoxic, antioxidant and membrane-protective action. The drug inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the ratio of lipid-protein, reduces the viscosity of the membrane, increases its fluidity. Mexidol modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, contributes to preserving the structural and functional organization of biomembart, and using the same patterns; Mexidol increases the content of dopamine in the brain. It causes an increase in the compensatory activity of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions, with an increase in ATP, creatine phosphate and activation of energy-synthesizing functions of mitochondria, and stabilization of cell membranes. Mexidol normalizes metabolic processes in the myocardial myocardial membrane, and in the case of myocardial myocardial membrane, it stabilizes cell membranes.restores and improves the electrical activity and contractility of the myocardium, as well as increases coronary blood flow in the ischemic zone, reduces the effects of the reperfusion syndrome in acute coronary insufficiency. Increases the antianginal activity of nitropreparatov. Mexidol contributes to the preservation of retinal ganglion cells and optic nerve fibers with progressive neuropathy, the causes of which are chronic ischemia and hypoxia. It improves the functional activity of the retina and optic nerve, increasing visual acuity.
Indications
- Acute disorders of cerebral circulation; - traumatic brain injury, consequences of traumatic brain injury; - dyscirculatory encephalopathy; - vegetative dystonia syndrome; - mild cognitive disorders of atherosclerotic genesis; - anxiety disorders in neurotic and neurosis-like states; days) as part of complex therapy; - primary open-angle glaucoma of various stages, as part of complex therapy; - relief of withdrawal syndrome in alcoholism with a predominance of it neurosis and vegetative-vascular disorders; - acute intoxication antipsychotics; - acute purulent and inflammatory processes of the abdominal cavity (acute necrotizing pancreatitis, peritonitis) in a complex therapy.
Contraindications
- Acute liver dysfunction; - Acute renal dysfunction; - Increased individual sensitivity to the drug.
Use during pregnancy and lactation
Mexidol is not recommended for use during pregnancy and lactation (breastfeeding) due to insufficient knowledge of the drug.
Dosage and administration
Mexidol is administered in / m or / in (jet or drip). To prepare the solution for infusion, the drug should be diluted in a 0.9% solution of sodium chloride. Mexidol is slowly injected in a jet for 5-7 minutes, and drip at a rate of 40-60 drops / min. The maximum daily dose should not exceed 1200 mg. In acute disorders of cerebral circulation, Mexidol is used in the first 10-14 days in / in the drip 200-500 mg 2-4 times / day, then in / m 200-250 mg 2- 3 times / day for 2 weeks. During traumatic brain injury and the consequences of traumatic brain injury, Mexidol is used for 10-15 days intravenously in a drop of 200-500 mg 2-4 times / day. During dyscirculatory encephalopathy in the decompensation phase Mexidol used in / in the jet or drip in a dose of 200-500 mg 1-2 times / day for 14 days,then - intramuscularly at 100-250 mg / day for the next 2 weeks. For course prevention of dyscirculatory encephalopathy, Mexidol is administered intramuscularly at a dose of 200-250 mg 2 times / day for 10-14 days. For mild cognitive impairment in elderly patients and for anxiety disorders, Mexidol is administered intramuscularly at a dose of 100-300 mg / day for 14-30 days. In acute myocardial infarction as part of complex therapy, Mexidol is administered intramuscularly or intramuscularly for 14 days, background of traditional therapy of myocardial infarction, including nitrates, beta-blockers, inhibitor ACE, thrombolytic agents, anticoagulant and antiplatelet agents, as well as symptomatic agents according to indications. In the first 5 days, to achieve maximum effect, it is desirable to administer the drug in / in the next 9 days Mexidol can be injected / m.V by drip infusion, slowly (to avoid side effects) on a 0.9% solution of sodium chloride or 5% dextrose solution (glucose) in a volume of 100-150 ml for 30-90 minutes. If necessary, slow jet administration of the drug for at least 5 minutes is possible. The drug is administered (w / w or v / m) 3 times / day every 8 hours. The daily therapeutic dose is 6–9 mg / kg body weight / day, one-time Dose - 2-3 mg / kg body weight. The maximum daily dose should not exceed 800 mg, a single 250 mg. In open-angle glaucoma of various stages as part of complex therapy, Mexidol is injected intramuscularly with 100-300 mg / day, 1-3 times / day for 14 days. In withdrawal alcohol syndrome Mexidol is administered in a dose of 200-500 mg intravenously in a drip or intramuscularly 2-3 times / day for 5-7 days. When acutely intoxicated with antipsychotics, Mexidol is administered intravenously at a dose of 200-500 mg / day for 7 -14 days. In acute purulent-inflammatory processes of the abdominal cavity (acute necrotic pancreatitis, peritonitis) Mexi ol administered on the first day in the preoperative and in the postoperative period. The doses administered depend on the form and severity of the disease, the extent of the process, the clinical course variants. Cancellation of the drug should be made gradually, only after a sustained positive clinical and laboratory effect. In acute edematous (interstitial) pancreatitis, Mexidol is prescribed 200-500 mg 3 times / day in / in drip (in isotonic sodium chloride solution) and i./m. necrotizing pancreatitisMild mexidol is prescribed on 100-200 mg 3 times / day in / in drip (in isotonic sodium chloride solution) and in / m. In case of moderate necrotic pancreatitis, 200 mg in 3 drops / day in / in drip ( isotonic solution of sodium chloride). In case of necrotic pancreatitis of a severe course - at a pulse dosage of 800 mg on the first day, with double administration, then 200-500 mg 2 times / day with a gradual decrease in the daily dose. In extremely severe form of necrotic pancreatitis initial dose of 800 mg / day to persistent stopping of manifestation eny pankreatogennogo shock, for stabilization - 300-500 mg 2 times a day / drip (in 0.9% sodium chloride solution), with a gradual reduction in the daily dosage.
Side effects
On the part of the digestive system: nausea and dryness of the oral mucosa may occur. Other: allergic reactions, drowsiness.
Overdose
Overdose may cause drowsiness.
Interaction with other drugs
Mexidol enhances the action of anxiolytics of benzodiazepine derivatives, anti-Parkinsonian (levodopa) and anticonvulsant (carbamazepine) agents. Mexidol reduces the toxic effects of ethyl alcohol.
special instructions
In some cases, especially in predisposed patients with bronchial asthma, with increased sensitivity to sulfites, severe hypersensitivity reactions may develop.