Nazol Advance nasal spray 10 ml
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Description
Clear liquid from colorless to light yellow color with a faint smell of menthol, eucalyptus and camphor.
Active ingredients
Oxymetazoline
Release form
Spray
Composition
100 ml contain: active ingredient: oxymetazoline hydrochloride 0.05 g, excipients: benzalkonium chloride 0.02 g, camphor racemic 0.17 g, eucalyptol (cineole) 0.17 g, levomenthol 0.17 g, disodium edetate dihydrate 0.1 g, polysorbate 80 0.2 g, propylene glycol 10 g, sodium hydrophosphate dihydrate 0.006 g, sodium dihydrogen phosphate dihydrate 0.65 g, hydrochloric acid, conc. 0,003 g, purified water 89,711,
Pharmacological effect
Oxymetazoline belongs to the group of alpha stimulants for topical use. Has a vasoconstrictor effect. With intranasal administration, the edema of the mucous membrane of the upper respiratory tract is reduced, which leads to the relief of nasal breathing and the opening of the mouths of the paranasal sinuses and the Eustachian tubes. The effect of the drug is manifested in 10-15 minutes after application and lasts for 10-12 hours.
Indications
For relief of nasal breathing with colds and viral infections of the upper respiratory tract, sinusitis, rhinitis of any etiology.
Contraindications
Hypersensitivity to the drug or its components, atrophic rhinitis, angle-closure glaucoma, marked atherosclerosis, conditions after transsphenoidal hypophysectomy, simultaneous use of monoamine oxidase inhibitors (including a period of 14 days after their withdrawal), children up to 6 years old, pregnancy, lactation period.
Precautionary measures
The drug should be used in patients with diseases of the cardiovascular system (arterial hypertension, coronary heart disease, chronic heart failure, tachycardia, arrhythmias), carbohydrate metabolism disorders (diabetes mellitus), hyperthyroidism, pheochromocytoma, chronic renal failure, prostatic hyperplasia (delayed urine), with an increase in intraocular pressure, taking tricyclic antidepressants.
Use during pregnancy and lactation
Use during pregnancy and during breastfeeding is possible only in the case when the intended benefits to the mother outweigh the possible risk to the fetus or infant.
Dosage and administration
Intranasal. The dose contains 0.025 mg of oxymetazoline hydrochloride. Adults and children over 12 years old - 2-3 doses in each nasal passage 2 times a day. Children from 6 to 12 years old - 1 dose in each nasal passage 2 times a day. Do not use the drug more than 2 times a day. Duration of treatment: It is not recommended to use the drug for more than 3 days. With frequent or prolonged use of the drug, a feeling of difficulty in nasal breathing may reappear or worsen. If these symptoms appear, you should stop treatment and consult a doctor. When injecting, do not tilt the head back and do not spray in the prone position.
Side effects
Burning or dryness of the mucous membrane of the nasal cavity, dryness in the mouth and throat, chihanie, an increase in the volume of secretions released from the nasal cavity. After the effect of the drug is used, a strong feeling of nasal congestion (reactive hyperemia). Side effects due to the systemic effect of the drug: increased arterial pressure, headache, dizziness, heartbeat, anxiety, nausea, insomnia. Benzalkoniya chloride, which is part of the drug, can cause irritation of the nasal mucosa. With prolonged use of the drug (more than 7 days) are possible: reactive hyperemia of the mucous membrane of the nasal cavity, atrophy of the mucous membrane of the nasal cavity, tachyphylaxis (rapid decrease in therapeutic effect with repeated use).
Overdose
In case of overdose or accidental intake of the drug inside, the following symptoms may develop: nausea, vomiting, cyanosis, fever, tachycardia, arrhythmia, increased blood pressure, shortness of breath, mental disorders, depression of the central nervous system (drowsiness, decrease in body temperature, bradycardia, decrease in arterial pressure, respiratory arrest and coma). Treatment is symptomatic; in case of accidental ingestion - gastric lavage, intake of activated carbon.
Interaction with other drugs
When used simultaneously with MAO inhibitors and tricyclic antidepressants, an increase in blood pressure may be observed. The drug slows down the absorption of local anesthetic drugs, lengthens their action. Joint use of other vasoconstrictor drugs increases the risk of side effects.
special instructions
In the recommended dosage without consultation with the doctor, use no more than 3 days. Avoid contact with eyes. The drug has an effect on vision, possibly reducing the reaction rate. In order to avoid the spread of infection, it is necessary to use the drug individually. With prolonged use (more than one week), the symptoms of nasal congestion may resume. Influence on the ability to drive machinery and other vehicles how the drug may cause dizziness and other side effects that may affect the indicated abilities.
Storage conditions
At a temperature not higher than 25 ° C. Keep out of the reach of children.