Nazol Spray Nasal 0.025% 10ml
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Description
Transparent, colorless, odorless solution.
Active ingredients
Oxymetazoline
Release form
Spray
Composition
100 ml contain: active ingredient: oxymetazoline hydrochloride 0.05 g, excipients: benzalkonium chloride 0.02 g, macrogol 400 7.5 g, povidone 0.4 g, propylene glycol 7.5 g, sodium hydrogen phosphate dihydrate 0.006 g, sodium dihydrophosphate dihydrate 0.65 g, disodium edetate dihydrate 0.1 g, hydrochloric acid conc. 0.003 g, purified water 86.571 g. 1 dose contains: active ingredient: oxymetazoline hydrochloride 0.025 mg, excipients: benzalkonium chloride 0.01 mg, macrogol 400 3.75 mg, povidone 0.2 mg, propylene glycol 3.75 mg, sodium hydrophosphate dihydrate 0.003 mg, sodium dihydrophosphate dihydrate 0.325 mg, disodium edetate dihydrate 0.05 mg, hydrochloric acid conc. 0.0015 mg, purified water 43.2855 mg.
Pharmacological effect
Oxymetazoline belongs to the group of alpha stimulants for topical use. Has a vasoconstrictor effect. With the introduction of intranasal reduces swelling of the mucous membrane of the upper respiratory tract, which leads to the relief of nasal breathing and the opening of the mouths of the paranasal sinuses and Eustachian tubes. The effect of the drug is manifested in 10-15 minutes after application and lasts for 10-12 hours.
Indications
For relief of nasal breathing with colds and viral infections of the upper respiratory tract, sinusitis, rhinitis of any etiology.
Contraindications
Hypersensitivity to the drug or its components, atrophic rhinitis, angle-closure glaucoma, severe atherosclerosis, conditions after transsphenoidal hypophysectomy, simultaneous use of monoamine oxidase inhibitors (including a period of 14 days after their withdrawal), children under 6 years of age, pregnancy, lactation period.
Precautionary measures
The drug should be used in patients with diseases of the cardiovascular system (arterial hypertension, coronary heart disease, chronic heart failure, tachycardia, arrhythmias), carbohydrate metabolism (diabetes), hyperthyroidism, pheochromocytoma, chronic renal failure, prostatic hyperplasia (delayed urine), with an increase in intraocular pressure, taking tricyclic antidepressants.
Use during pregnancy and lactation
Use during pregnancy and breastfeeding is possible only when the intended benefits to the mother outweigh the possible risk to the fetus or infant.
Dosage and administration
Intranasal. 1 dose contains 0,025 mg oxymetazoline hydrochloride. Adults and children over 12 years old - 2-3 doses in each nasal passage 2 times a day. Children from 6 to 12 years old - 1 dose in each nasal passage 2 times a day. Do not use the drug more than 2 times a day. Duration of treatment: It is not recommended to use the drug for more than 3 days. With frequent or long-term use of the drug, a feeling of difficulty in nasal breathing may appear again or worsen. If these symptoms appear, you should stop treatment and consult a doctor. When injecting, do not tilt the head backwards or spray when lying down.
Side effects
Burning or dryness of the nasal mucosa, dryness in the mouth and throat, sneezing, an increase in the volume of secretions released from the nasal cavity. After the effect of the drug is passed, a strong feeling of nasal congestion (reactive hyperemia). Side effects caused by the systemic action of the drug: increased blood pressure, headache, dizziness, feeling of heartbeat, anxiety, nausea, insomnia. With prolonged use of the drug (more than 7 days), the following are possible: reactive hyperemia of the mucous membrane of the nasal cavity, atrophy of the mucous membrane of the nasal cavity, tachyphylaxis (a rapid decrease in the therapeutic effect with repeated use). Benzalkoniya chloride, which is part of the drug, can cause irritation of the nasal mucosa.
Overdose
In case of overdose or accidental ingestion of the drug, the following symptoms may develop: nausea, vomiting, cyanosis, fever, tachycardia, arrhythmia, increased blood pressure, shortness of breath, mental disorders, depression of the central nervous system (drowsiness, decrease in body temperature, bradycardia, decrease in blood pressure, respiratory arrest and coma). Treatment is symptomatic; in case of accidental ingestion - gastric lavage, intake of activated carbon.
Interaction with other drugs
With simultaneous use with MAO inhibitors (including the period within 14 days after their cancellation) and tricyclic antidepressants, an increase in blood pressure may be observed. The drug slows down the absorption of local anesthetic drugs, lengthens their action.Co-administration of other vasoconstrictor drugs increases the risk of side effects.
special instructions
In the recommended dosage without consultation with the doctor, use no more than 3 days. Avoid contact with eyes. The drug has an effect on vision, possibly reducing the reaction rate. To avoid the spread of infection, you must use the drug individually. With prolonged use (more than one week), the symptoms of nasal congestion may resume. Influence on the ability to drive machinery and other vehicles: during treatment, you should refrain from driving and practicing other potentially dangerous activities that require increased concentration of attention or quickness of psychomotor reactions, since the drug can cause dizziness and other side effects that can affect the indicated abilities.
Storage conditions
At a temperature not higher than 25 ºС. Keep out of the reach of children.