Nolicin 400mg coated pills N10
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Active ingredients
Norfloxacin
Release form
Pills
Composition
Active ingredient: Norfloxacin (Norfloxacinum) Active ingredient concentration (mg): 400
Pharmacological effect
Antimicrobial drug of the fluoroquinolone group of a wide spectrum of action. It has a bactericidal effect. It affects the bacterial enzyme DNA gyrase, which provides supercoiling and, thus, the stability of bacterial DNA. Destabilization of the DNA chain leads to the death of bacteria. It has a broad spectrum of antibacterial action. Staphylococcus aureus (including methicillin-resistant strains of Staphylococcus spp. Susceptible), Staphylococcus epidermidis, Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, and Citrobacter a-Ref, are sensitive to the drug. Proteus spp. (indole-positive and indole-negative strains), Salmonella spp., Shigella spp., Chelnye Chelnya, Pochomonas jehuni, Pochomonas shes. sensitivity to the drug have: Enterococcus faecalis, Streptococcus spp. (Streptococcus pyogenes, Streptococcus pneumoniae and Streptococcus viridans), Serratia marcescens, Pseudomonas aeruginosa, Acinetobacter spp., Mycoplasma hominis, Mycoplasma pneumoniae, Mycobacterium tuberculosis, Mycobacterium in a sample, on-the-job, a site, a site, a site, a network, a network, a network, etc.
Pharmacokinetics
Absorption After ingestion, norfloxacin is rapidly, but not completely (20-40%) absorbed from the gastrointestinal tract. Cmax are observed in 1-2 hours and range from 0.8 to 2.4 mcg / ml, depending on the dose. Food intake slows down drug absorption. Distribution and metabolism A low amount of binding of norfloxacin to plasma proteins (10-15%) and high solubility in lipids cause a large Vd of the drug and good penetration into organs and tissues (parenchyma of the kidneys, ovaries, fluid of the seminiferous tubules, prostate gland, uterus, abdominal and pelvic organs, bile, breast milk). It penetrates the BBB and the placental barrier. It is slightly metabolized in the liver. Excretion of T1 / 2 is 3-4 hours. Excreted by the kidneys, by glomerular filtration and tubular secretion. Within 24 hours from the moment of taking, 32% of the dose is excreted by the kidneys in unchanged form, 5-8% - as metabolites, about 30% of the accepted dose is excreted in bile.
Indications
Symptomatic therapy of painful and inflammatory processes of various origins, including: - inflammatory and degenerative diseases of the musculoskeletal system: • rheumatoid arthritis; • seronegative arthritis: ankylosing spondylitis - ankylosing spondylitis, psoriatic arthritis, reactive arthritis (Reiter's syndrome); • gout, pseudogout; • osteoarthritis; • tendonitis, bursitis, myalgia, neuralgia, sciatica; - pain, including weak,moderate and pronounced: • headache; • toothache; • post-traumatic and postoperative pain syndrome; • pain syndrome in oncological diseases; • algomenorrhea.
Contraindications
Hypersensitivity to norfloxacin, components of the drug and other quinolones, deficiency of glucose-6-phosphate dehydrogenase, children and adolescents (under 18), pregnancy and lactation;
Use during pregnancy and lactation
During the period of treatment with norfloxacin, patients should receive a sufficient amount of fluid (under the control of diuresis). During the period of therapy, the prothrombin index may increase (during surgical interventions, the blood clotting system should be monitored). During treatment with norfloxacin, exposure to direct sunlight should be avoided. in tendons or at the first signs of tendovaginitis, the drug should be discontinued. During therapy with norfloxacin, it is recommended to avoid excessive physical exertion. In the presence of an allergic reaction to acetylsalicylic acid, E110 azo dye (dispersed yellow dye, E110) can cause a hypersensitivity reaction, including bronchospasm. Impact on ability to drive vehicles and drive mechanisms. and other potentially hazardous activities that require increased concentration and psychomotor speed eaktsy (especially while used ethanol).
Dosage and administration
Inside on an empty stomach (at least 1 hour before or 2 hours after eating) and washed down with a sufficient amount of liquid. In the absence of specific doctor's instructions, the following doses are recommended: 1 tablet (400 mg), 2 times a day. Duration of treatment from 7 to 14 days, if necessary, conduct a longer treatment. In chronic bacterial prostatitis, 400 mg is prescribed 2 times a day for 4-6 weeks or more. With uncomplicated gonorrhea, the drug is prescribed once in a dose of 800-1200 mg or 2 times a day, 400 mg for 3-7 days. For bacterial gastroenteritis (shigellosis, salmonellosis), it is recommended to take 400 mg 2 times a day for up to 5 days.For the prevention of travelers' diarrhea, it is recommended to take 400 mg per day 1 day before departure, during the entire travel time and 2 days after its end (no more than 21 days). For the prevention of sepsis with neutropenia, 400 mg is prescribed 2 times a day for up to 8 weeks. For acute uncomplicated cystitis, 400 mg is prescribed 2 times a day for 3-5 days. For the prevention of recurrent uncomplicated urinary tract infections with frequent exacerbations (more than 3 episodes per year or more than 2 within six months), the drug is prescribed 200 mg (1/2 pills of Nolicin) 1 time for the night for a long time (from 6 months to several years old). Patients with impaired renal function with creatinine clearance of more than 20 ml / min do not require correction of the dosage regimen. When creatinine clearance is less than 20 ml / min (or the level of serum creatinine is higher than 5 mg / 100 ml) and patients on hemodialysis, one-half of the therapeutic dose of Nolicin 2 times a day or a full dose of the drug 1 time per day is prescribed.
Side effects
With simultaneous use of norfloxacin and theophylline should be monitored concentration of theophylline in the blood plasma and adjust its dose, because Norfloxacin reduces theophylline clearance by 25%, and the development of corresponding undesirable side effects can be observed. Norfloxacin reduces the effect of nitrofurans. Norfloxacin may enhance the therapeutic effect of cyclosporine and warfarin, in some cases, an increase in serum creatinine concentration was observed control of this indicator. Simultaneous use of norfloxacin and antacid agents containing aluminum hydroxide or magn Ia, as well as preparations containing iron, zinc, sucralfate, reduces the absorption of norfloxacin (the interval between their intake should be at least 2 hours). Simultaneous use with drugs that reduce seizure threshold can lead to the development of epileptiform seizures. Simultaneous use with GCS may increase the risk of tendinitis or tendon rupture. Norfloxacin may enhance the therapeutic effect of hypoglycemic drugs (sulfonylurea derivatives). Simultaneous use of norflox ching with drugs that have the potential ability to lower blood pressure, it can cause a sharp decline.In this regard, in such cases, as well as with simultaneous administration with barbiturates and other drugs for general anesthesia, HR, BP and ECG indicators should be monitored.
Overdose
Side Effects Of the digestive system: loss of appetite, bitter taste in the mouth, nausea, vomiting, abdominal pain, diarrhea, pseudomembranous enterocolitis (with prolonged use), increased activity of “liver” transaminases. , albuminuria, urethral bleeding, increased urea and plasma creatinine. On the nervous system: headache, dizziness, fainting, insomnia, hallucinations. Elderly patients may have: fatigue, drowsiness, anxiety, irritability, fear, depression, noise in the ears. On the part of the cardiovascular system: tachycardia, arrhythmias, lowering blood pressure, vasculitis. Allergic reactions: rash, pruritus, urticaria, swelling , malignant exudative erythema (Stevens-Johnson syndrome). On the part of the musculoskeletal system: arthralgia, tendenitis, tendon ruptures (usually in the case of a combination with contributing factors). On the side of the hematopoietic system: eosinophilia, ikopenia, decrease in hematocrit. Others: candidiasis.
Interaction with other drugs
Precautionary measures
special instructions
Symptoms: nausea, vomiting, diarrhea; in more severe cases - dizziness, drowsiness, cold sweat, convulsions, puffy face without changing the basic hemodynamic indications. Treatment: gastric lavage, adequate hydration therapy with forced diuresis and symptomatic therapy. Required examination and observation in the hospital for several days. There is no specific antidote.