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Active ingredients
Methyluracil + Ofloxacin + Lidocaine
Release form
Ointment
Composition
Ofloxacin 10 mg, dioksometiltetragidropirimidin (methyluracil) 40 mg lidocaine hydrochloride (monohydrate) 30 mg.Vspomogatelnye ingredients: Macrogol 1500 (polyethylene 1500, low molecular weight polyethylene glycol 1500), macrogol 400 (polyethylene 400, polyethylene glycol 400 low molecular weight), propylene glycol, methyl parahydroxybenzoate ( nipagin or methylparaben), propyl parahydroxybenzoate (nipazol or propyl paraben).
Pharmacological effect
The combined drug has antimicrobial, anti-inflammatory, local anesthetic, regenerating effect. Ofloxacin is a broad spectrum antimicrobial agent from the fluoroquinolone group. It has a bactericidal effect due to the blockade of DNA gyrase in bacterial cells. Highly active against gram-positive microorganisms: Staphylococcus spp. (including Staphylococcus aureus, Staphylococcus epidermidis), Streptococcus spp .; Gram-negative microorganisms: Pseudomonas aeruginosa, Acinetobacter spp., Escherichia coli, Klebsiella spp., Proteus spp., Enterobacter spp., Citrobacter spp .; anaerobes: Propionibacterium acnes; intracellular microorganisms: Chlamydia spp. (including Chlamydia trachomatis), Legionella spp., Mycoplasma spp. Methyluracil - tissue repair stimulator. It has anabolic activity. Accelerates cell regeneration processes in wounds, accelerating growth and granulation tissue maturation and epithelization. Lidocaine has a local anesthetic effect due to the blockade of sodium channels, which prevents the generation of impulses at the end of sensitive neurons and conduction of impulses along the nerve fibers. When applied externally, it dilates the blood vessels and does not have a local irritating effect. The water-soluble hydrophilic (hyperosmolar) basis of the ointment is a mixture of polyethylene oxides (polyethylene glycols) with a molecular mass of 400 and 1500, providing a dehydrating (moisture absorbing) effect on the tissue, 20 times more powerful than the hyperosmotic effect sodium chloride solution.
Pharmacokinetics
Data on the pharmacokinetics of the drug Oflomelide; not provided.
Indications
Infected purulent wounds of various localization and etiology in the first (purulent-necrotic) phase of the wound process, including accompanied by severe pain syndrome: - infected burns of grade II-IV; - pressure sores; - trophic ulcers; - postoperative and post-traumatic wounds and fistulas; .
Contraindications
- pregnancy; - lactation period; - children and adolescents up to 18 years; - hypersensitivity to the drug.
Precautionary measures
Use in children. Contraindications: children and adolescents up to 18 years.
Use during pregnancy and lactation
The drug is contraindicated in pregnancy and lactation (breastfeeding).
Dosage and administration
The drug is used externally, 1 time / day for 1-2 weeks. The maximum daily dose should not exceed 100 g of ointment. The duration of treatment depends on the dynamics of cleansing wounds from purulent exudate and the periods of relief of the inflammatory process. After standard treatment of wounds and burns, ointment is applied directly to the wound surface with a thin layer (after that they apply a sterile gauze bandage) or a gauze bandage followed by application to the lesion. Tampons soaked with ointment, loosely fill the cavities of purulent wounds after their surgical treatment, and gauze turunda with ointment is injected into the fistulous passages. In the treatment of infected burns s drug is used daily or 2-3 times a week, depending on the amount of purulent discharge.
Side effects
Possible: allergic reactions.
Overdose
Data on the overdose of the drug Oflomelide; not provided.
Interaction with other drugs
There are no cases of drug interactions that would reduce the effectiveness and safety of the drugs used.