Procto-Glyvenol rectal suppositories 400 mg + 40 mg 10 pcs
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Active ingredients
Tribenozide + Lidocaine
Release form
Suppositories
Composition
In 1 suppositories: tribenozid 400 mg, lidocaine 40 mg. Excipients: Witepsol E85 (suppository mass n ° 1) - 305 mg, Witepsol W35 (suppository mass n ° 2) - 1255 mg.
Pharmacological effect
Combined antihemorrhoidal drug.Tribenoside reduces capillary permeability and improves vascular tone, antagonistically affects some endogenous substances that act as mediators in the development of inflammation and pain. Lidocaine has a local anesthetic effect. .
Pharmacokinetics
Absorption The systemic bioavailability of tribenoside, coming from the suppository, reaches 30% of the amount that is absorbed when taking the drug inside. After rectal administration of 1 suppository (400 mg), Cmax of tribenoside in plasma is reached after 2 hours and amounts to 1 μg / ml (tribenoside + metabolites). Metabolism Tribenoside is largely metabolized in the liver. Excretion of 20-27% of the dose is excreted in the urine as metabolites.
Indications
External and internal hemorrhoids
Contraindications
- hypersensitivity to the components of the drug; - liver failure; - I trimester of pregnancy.
Use during pregnancy and lactation
Use in the first trimester of pregnancy is contraindicated. When using the drug in the II and III trimesters of pregnancy, it is necessary to take into account the possible risk to the fetus. If necessary, the use of the drug during breastfeeding should weigh the expected benefit of therapy for the mother and the potential risk to the baby.
Dosage and administration
Rectally. In case of marked clinical symptoms, 1 suppository is administered in the morning and evening. When acute symptoms regress, 1 suppository is administered 1 time / day.
Side effects
On the part of the immune system: very rarely (less than 1/10 000) - anaphylactic reactions, including angioedema, swelling of the face, bronchospasm and cardiovascular disorders. On the side of the skin and subcutaneous tissues: rare (more than / 10 000, less than 1/1 000) - skin reactions at the site of application (burning, rash, itching and urticaria). These symptoms may extend beyond the site of application.
Overdose
Cases of drug overdose are not registered. In case of accidental ingestion, gastrointestinal flushing is recommended, as well as symptomatic supportive therapy.
Interaction with other drugs
Without features.
special instructions
If the symptoms of the disease do not diminish in the course of treatment or new unusual sensations are noted, you should consult a doctor. when driving in doses not exceeding the recommended ones, the drug does not affect the ability to perform work related to neo walk concentration, rapid mental and motor responses.