Solcoseryl solution for intravenous and intramuscular injection of ampoules 5 ml 5 pcs
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Active ingredients
Deproteinized dialysate from the blood of dairy calves
Release form
Solution
Composition
1 ml contains: deproteinized dialysate from the blood of healthy dairy calves (in terms of dry matter) 42.5 mg. Auxiliary substances: water d / and.
Pharmacological effect
Stimulator of tissue regeneration. It is a depotinized dialysate from the blood of dairy calves, containing a wide range of low molecular weight components of cell mass and serum with a molecular weight of 5000 D (including glycoproteins, nucleosides and nucleotides, amino acids, oligopeptides). Solcoseryl improves the transport of oxygen and glucose to cells under hypoxia, increases the synthesis of intracellular ATP and increases the dose of aerobic glycolysis and oxidative phosphorylation, activates reparative and regenerative processes in tissues, stimulates the proliferation of fibroblasts and synthesis of collagen of the vascular wall.
Pharmacokinetics
Conducting studies of the pharmacokinetic processes of absorption, distribution and excretion of the drug using standard chemical-analytical methods is not possible, because In its composition, the drug contains blood components and substances that are usually found in the body.
Indications
Occlusive peripheral arterial disease in stage II according to Fontein in patients with an initial distance of painless walking below 100 m in cases where the use of therapeutic walking as monotherapy did not lead to the desired results.
Contraindications
Age up to 18 years. Hypersensitivity to the drug.
Precautionary measures
Solcoseryl should not be applied to a contaminated wound, as it does not contain antimicrobial ingredients. The use of Solcoseryl, as well as all other drugs, is undesirable during pregnancy and lactation and is possible only when absolutely necessary and under the supervision of a physician. In case of pain, reddening of the skin near the site of application of Solcoseryl, secretion from the wound, fever is necessary urgently seek medical attention. If, when applying Solcoseryl, the healing of the affected area is not observed within 2-3 weeks, it is necessary to consult a doctor.
Use during pregnancy and lactation
So far, no cases of Solcoseryl's teratogenic effects are known, however, the drug should be used during pregnancy with caution, according to strict indications and under the supervision of a physician. There are no data on the safety of using Solcoseryl during lactation, it should be discontinued if necessary.
Dosage and administration
The drug is used parenterally (v / v, v / m), externally, topically. When treating occlusive diseases of peripheral arteries in stage II, Fontein prescribes a solution for intravenous drip infusion of 250 ml daily or several times a week at a rate of 20-40 drops per minute. The course of treatment consists of 20 infusions. In the treatment of occlusive diseases of peripheral arteries in stage III-IV in the Fountain, the use of the solution for injection is recommended. It is administered in / in 20 ml daily. Perhaps in / in the drip injection of the drug in an isotonic solution of sodium chloride or 5% glucose solution. In the treatment of chronic venous insufficiency, accompanied by trophic disorders, a solution for injection is injected in 10 ml / 3 times a week. The duration of therapy is no more than 4 weeks and is determined by the clinical picture of the disease. If intravenous administration is not possible, the drug can be administered intramuscularly at 2 ml / day. In the presence of local trophic disorders (stage IV in the Fountain), the simultaneous use of a gel or ointment is recommended, but only after the removal of necrotic tissue from the wound. When a / in the introduction of undiluted drug, it must be administered slowly, because it is a hypertonic solution.
Side effects
Allergic reactions (urticaria, hyperemia and edema at the injection site, fever.
Overdose
To date, cases of overdose of the drug Solcoseryl when it is used according to the indications in the recommended doses were not reported.
Interaction with other drugs
With caution, apply simultaneously with drugs that increase the content of potassium in the blood (potassium preparations, potassium-sparing diuretics, ACE inhibitors). Pharmaceutical interaction: The drug should not be mixed with the introduction of other drugs (especially phytoextracts).The drug is incompatible with parenteral forms of Ginkgo biloba, naphthidrofuryl, and benzikan fumarate.
special instructions
In the case of adverse reactions should stop using the drug and prescribe symptomatic therapy.
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