Troxerutin-Zentiva capsules 300mg N30
Condition: New product
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Active ingredients
Troxerutin
Release form
Capsules
Composition
1 capsule contains: troxerutin 300 mg. Excipients: macrogol 6000 - 12 mg, magnesium stearate - 3.12 mg.; Capsule body composition: titanium dioxide - 2%, gelatin - up to 100%; Capsule lid composition: quinoline yellow dye - 0.713%, iron dye red oxide - 0.005 %, titanium dioxide - 2%, gelatin - up to 100%.
Pharmacological effect
Semisynthetic bioflavonoid (a derivative of rutin) class benzopyranes. Venotonic, angioprotective drug. It reduces the permeability and fragility of capillaries, strengthens the vascular wall, improves microcirculation, has a positive flow effect. Participates in redox processes, has antioxidant activity. Increases the density of the vascular wall, reduces the exudation of the liquid part of the plasma and the diapedesis of blood cells in the tissue, reduces inflammation in the vascular wall, limiting adherence to its surface platelets.; Troxerutin can be used both at the initial and late stages of chronic venous insufficiency treatment, it is possible as one of the components of complex treatment. Troxerutin reduces puffiness and a feeling of heaviness in the legs, reduces the intensity of pain and cramps, improves tissue trophism. Troxerutin relieves symptoms associated with hemorrhoids (pain, exudation, itching, bleeding) retinopathy. The effect of troxerutin on the rheological properties of blood helps to prevent the development of retinal microthrombosis.
Pharmacokinetics
Absorption; After ingestion, the drug is absorbed from the gastrointestinal tract, Cmax in plasma is observed on average 2 hours after ingestion.; Metabolism and excretion; Partially metabolized in the liver. Mostly excreted through the intestines (up to 65-70%), a smaller part (up to 25%) is excreted unchanged by the kidneys. T1 / 2 troxerutin is approximately 24 hours.
Indications
Chronic venous insufficiency; trophic disorders in chronic venous insufficiency (dermatitis, trophic ulcers); phlebeurysm; superficial thrombophlebitis, periphlebitis; postthrombotic syndrome; post-traumatic edema, hematomas; hemorrhoids; diabetic angiopathy, retinopathy.
Contraindications
Peptic ulcer and duodenal ulcer; chronic gastritis (in the acute phase); I trimester of pregnancy; lactation period (breastfeeding); children and adolescents under 18 years of age (experience of use is limited); hypersensitivity to troxerutin and other components of the drug.
Use during pregnancy and lactation
The use of the drug Troxerutin Zentiva during the first trimester of pregnancy is contraindicated. The possibility of using the drug in the II and III trimesters of pregnancy is determined by the doctor. Application is possible only if the intended benefit of treatment for the mother outweighs the potential risk to the baby. There are no data on the penetration of troxerutin into breast milk. The use of the drug Troxerutin Zentiva during breastfeeding is contraindicated.
Dosage and administration
The drug is taken orally. Capsules should be swallowed whole, with meals, with a sufficient amount of liquid.; Troxerutin Zentiva should be used as directed by the doctor. The recommended dose is 1 caps. 3 times / day; as maintenance therapy - 1 caps. 2 times / day; The course of treatment is on average 3-4 weeks; the need for longer treatment is determined individually.
Side effects
Seldom: Nausea, headache
Overdose
Troxerutin has a very low toxicity. With an overdose, the following symptoms may appear: agitation, nausea, headache, and blood flushes to the face. Seek medical attention, if necessary, carry out symptomatic and supportive treatment.
Interaction with other drugs
With simultaneous use enhances the effect of ascorbic acid on the resistance and permeability of the vascular wall.
special instructions
When treating superficial thrombophlebitis or deep vein thrombosis, the use of Troxerutin Zentiva does not exclude the need for anti-inflammatory and antithrombotic drugs. Pediatric use the management of mechanisms; The use of the drug Troxerutin Zentiva does not affect the motor and mental reactions, does not interfere with the management vehicles and work with mechanisms.