Vinpocetine Forte Canon 10mg N30 Tablets
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Active ingredients
Vinpocetine
Release form
Pills
Composition
1 tablet contains: Active ingredient: Vinpocetine 10 mg. Excipients: Magnesium stearate, colloidal silicon dioxide, talc, lactose monohydrate, corn starch.
Pharmacological effect
A means of improving cerebral circulation and brain metabolism. Inhibits phosphodiesterase activity, which contributes to the accumulation of cAMP in tissues. It has a vasodilating effect mainly on the vessels of the brain, which is caused by direct myotropic antispasmodic action. Systemic blood pressure drops slightly. It improves blood circulation and microcirculation in the brain tissues, reduces platelet aggregation, and contributes to the normalization of the rheological properties of blood. It improves the tolerance of hypoxia by brain cells, facilitating the transport of oxygen to tissues due to a decrease in the red blood cell affinity for it, enhancing the absorption and metabolism of glucose. Increases the content of catecholamines in brain tissue.
Pharmacokinetics
When ingestion is rapidly absorbed from the gastrointestinal tract. Cmax in plasma is reached in approximately 1 hour. When administered parenterally, Vd is 5.3 L / kg. T1 / 2 is about 5 h.
Indications
Acute and chronic cerebrovascular insufficiency. Dyscirculatory encephalopathy, accompanied by impaired memory, dizziness, headache. Posttraumatic encephalopathy. Vascular diseases of the retina and choroid. Hearing impairment of vascular or toxic origin. Meniere's disease. Vertigo labyrinth origin. Vegetative-vascular dystonia in menopausal syndrome.
Contraindications
Pregnancy. Lactation period. Hypersensitivity to vinpocetine. With caution used inside: Arrhythmias. Angina pectoris. Unstable blood pressure. Low vascular tone.
Precautionary measures
Since the cardiovascular system: transient arterial hypertension, tachycardia; rarely - beats, an increase in time of excitation of the ventricles.
Use during pregnancy and lactation
Contraindicated for use in pregnancy. Data on the safety of use during lactation are not available.
Dosage and administration
For oral administration - 5-10 mg 3 times / day. Before the abolition of the drug should gradually reduce the dosage. Possible repeated courses 2-3 times a year.
Side effects
On the part of the cardiovascular system, Transient arterial hypertension, tachycardia. Rarely, beats, an increase in the time of excitation of the ventricles.
Interaction with other drugs
When applied simultaneously with warfarin, a small decrease in the anticoagulant effect of warfarin has been reported. With simultaneous parenteral administration of vinpocetine and heparin, there may be an increased risk of bleeding.
special instructions
With caution used internally for arrhythmias, angina, with unstable blood pressure and low vascular tone. Parenteral, as a rule, is used in acute cases to improve the clinical picture, then move to ingestion. In chronic diseases, Vinpocetine is taken orally. In hemorrhagic cerebral stroke, parenteral administration of vinpocetine is allowed only after the reduction of acute events (usually 5-7 days).