Vinpotropile capsules 5 mg + 400 mg 60 pcs
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Active ingredients
Vinpocetine + Piracetam
Release form
Capsules
Composition
Active ingredient: Vinpocetine + Piracetam (Vinpocetinum + Piracetamum) Active ingredient concentration (mg): Vinpocetine 5 mg, piracetam 400 mg
Pharmacological effect
Nootropic combination drug, also has vasodilating properties. Improves cerebral circulation, causes a slight decrease in systemic blood pressure. It increases the resistance of brain cells to hypoxia, facilitates the transport of oxygen and substrates of energy supply to tissues (due to a decrease in the erythrocyte affinity for oxygen, increased absorption and glucose metabolism, and a switch to aerobic processes). It promotes the accumulation of cAMP and ATP in the tissues, an increase in the content of catecholamines in the brain tissues. The vasodilating effect is associated with a direct relaxing effect on the smooth muscles of the vessels, mainly of the brain. The drug does not cause the phenomenon of robbery and increases the blood supply to the ischemic area of the brain, without affecting the blood supply to intact areas. Improves microcirculation in the brain by reducing platelet aggregation, reducing blood viscosity, increasing red blood cell deformability. It has a positive effect on metabolic processes in brain cells, increases ATP concentration in brain tissue, enhances the synthesis of ribonucleic acid and phospholipids, as well as glucose utilization. It improves the integrative activity of the brain, contributes to the consolidation of memory, facilitates the learning process, changes the speed of propagation of excitation in the brain. Enhances alpha and beta activity, reduces delta activity on EEG, reduces the severity of vestibular nystagmus, improves communication between the hemispheres and synaptic conduction in neocortical structures, increases mental activity, increases cerebral blood flow, does not have a sedative, psychostimulating effect. .
Pharmacokinetics
Vinpocetine After taking the drug inside Vinpocetine is well absorbed from the gastrointestinal tract, bioavailability is about 50-70%. Сmax is reached 1 hour after administration. The therapeutic plasma concentration varies from 10 to 20 ng / ml.T1 / 2 - 4.8 parts. PyracetamAfter taking the drug inside, it is well absorbed from the gastrointestinal tract, bioavailability is about 95%. Сmax is reached in 0.5-1 h after ingestion. It penetrates the BBB, accumulates in the brain tissues in 1-4 hours after ingestion. It is removed from the cerebrospinal fluid much more slowly than from other tissues and body fluids. Practically not biotransformed in the body and 2/3 is excreted by the kidneys unchanged for 30 hours. T1 / 2 from plasma is 4.5 hours, from the brain - 7.7 hours
Indications
Insufficiency of cerebral circulation (recovery period of ischemic and hemorrhagic stroke, encephalopathy of various origins); - vascular genesis parkinsonism; - intoxication; - brain injuries and other diseases of the central nervous system accompanied by a decrease in intellectual-mental functions; - Asthenic syndrome; - Labyrinthopathy, Meniere's syndrome; - Migraine prevention; - Kinetoses prevention.
Contraindications
Severe cardiac arrhythmias - IHD (severe); - Acute stage of hemorrhagic stroke; - Renal failure; - Hepatic insufficiency; - Children under 14; - Pregnancy; - Lactation (breastfeeding); - Hypersensitivity to the components of the drug.
Use during pregnancy and lactation
The drug is contraindicated in pregnancy and lactation.
Dosage and administration
Adults and adolescents over the age of 14 take 1-2 capsules 3 times / day. Maintenance dose - 1 capsule 3 times / day. The duration of treatment is from 2-3 weeks to 2-6 months. Capsules should be taken without chewing, before eating, drinking plenty of water.
Side effects
On the part of the central nervous system: mental and motor agitation, irritability, imbalance, decreased ability to concentrate, anxiety, sleep disturbances, dizziness, headache, extrapyramidal disorders. From the alimentary system: gastralgia, nausea, vomiting, constipation, diarrhea, decreased appetite. From the side of the cardiovascular system: worsening of the course of stenocardia, tachycardia, extrasystole, slowing down of AV-conduction. Others: increase of sexual activity. The preparation is well tolerated. Side effects are noted in rare cases.
Overdose
Data on drug overdose Vinpotropile not provided.
Interaction with other drugs
When combined, Vinpotropile increases the risk of hemorrhagic complications of heparin therapy, enhances the effects of thyroid hormones, antipsychotics (neuroleptics), and indirect anticoagulants. When used simultaneously, Vinpotropile reduces the effect of anticonvulsants (reduces the seizure threshold).
special instructions
Before the abolition of the drug dose Vinpotropila should be reduced gradually.