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Active ingredients
Clotrimazole
Release form
Powder
Composition
Each gram of the preparation contains: Active substance: Clotrimazole 10.0 mg Auxiliary substances: propylene glycol 990.0 mg
Pharmacological effect
Antifungal broad-spectrum agent for local use, antibacterial, antiprotozoal, trichomonacid. The antimycotic effect of the active ingredient clotrimazole (imidazole derivative) is associated with impaired synthesis of ergosterol, which is part of the cell membrane of fungi, which changes the permeability of the membrane and causes the subsequent lysis of the cell. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells. It shows fungicidal and fungistatic activity against dermatomycetes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast-like and mold fungi (Candida spp., Including Candida albicans; Torulopsis, and fungi and mold fungi, and the subject, and not to get the subject of a subject that is used by a non-human, fungi and mold fungi (Candida spp., Candida albicans; It is active against the pathogen of multi-colored lichen - Pityrosporum orbiculare (Malassezia furfur). Effective against gram-positive bacteria - the causative agent of erythrasma Corynebacterium minutissimum, as well as Staphylococcus spp., Streptococcus spp., Gram-negative bacteria - Bacteroides, Gardnerella vaginalis. In high concentrations active against Trichomonas vaginalis.
Pharmacokinetics
Absorption When applied topically, clotrimazole is poorly absorbed through the skin. Bioavailability is less than 0.5%. Distribution Accumulates in the stratum corneum of the epidermis at a concentration higher than the minimum inhibitory concentration (MIC) for most pathogenic fungi (50-100 mcg / ml). Concentration in the basal layer of the epidermis is 1.53 - 3 mcg / ml. Penetrates the keratin nails. Metabolism and excretion In the liver biotransformed to inactive metabolites and excreted through the intestines. Excreted through the kidneys (the proportion of renal excretion is 0.05% - 0.5%). The half-life of the original substance is 3.5 - 5 hours.
Indications
Fungal infections of the skin, interdigital fungal erosion, mycoses, complicated by secondary infection, versicolor versicolor, erythrasma.
Contraindications
hypersensitivity to clotrimazole or other components of the drug I trimester of pregnancy.
Use during pregnancy and lactation
In clinical and experimental studies it was not established that the use of the drug during pregnancy or during breastfeeding has a negative impact on the health of the woman or the fetus (child). However, the question of the advisability of prescribing the drug in the II or III trimester should be decided individually after consulting with a doctor. When prescribing the drug during the II or III trimester of pregnancy, consider the ratio of the intended benefits of prescribing the drug for the mother and the possible risk to the fetus. Application of the drug directly on the lactating mammary gland is contraindicated.
Dosage and administration
Outwardly. Apply to cleansed and dry skin twice a day (morning and evening). Candid powder can also be sprayed onto clothing or shoes that are in direct contact with the affected areas. Candid powder can be used in combination with drugs Candid cream for external use of 1% or Candid solution for external use of 1%. The duration of therapy is individual and depends on the severity and location of the disease. To achieve complete recovery, treatment with the drug should not be stopped immediately after the disappearance of the acute symptoms of inflammation or subjective complaints. The duration of therapy should be, on average, about 3-4 weeks. For successful treatment is important regular use of the drug.
Side effects
When applied topically to the skin (rarely): erythema, tingling, burning, irritation, itching, urticaria, edema. If any of the side effects indicated in the instruction are aggravated, or you have noticed any other side effects not indicated in the instruction, inform your doctor.
Overdose
Overdose is unlikely.
Interaction with other drugs
Clotrimazole reduces the activity of amphotericin B and other polyene antibiotics. With simultaneous use with natamycin and nystatin, the activity of clotrimazole may be reduced.
special instructions
the drug is intended for external use only; avoid contact with eyes; use the drug for children under 2 years of age only under the supervision of a physician; If swallowed accidentally, consult a doctor.The drug does not affect the ability to drive vehicles and engage in other potentially hazardous activities that require high concentration of attention and psychomotor speed reactions.