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Active ingredients
Benzocaine + Benzalkoniya chloride + Tirotricin
Release form
Pills
Composition
1 tablet contains: benzalkonium chloride 1 mg benzocaine 1.5 mg thyrotricin 0.5 mg Supplementary substances: sorbitol 871 mg, talc 80 mg, povidone (polyvidone K25) 10 mg, carmellose sodium 10 mg, sucrose stearate 20 mg, peppermint pepper oil 5 mg, sodium saccharinate 1 mg.
Pharmacological effect
A complex drug whose action is due to its constituent components. Benzocaine is a local anesthetic that reduces pain when swallowing, which often accompanies infectious-inflammatory processes of the mouth and throat. Benzalkonium chloride is a quaternary ammonium compound, belongs to cationic surfactants, interacts with lipoproteins, and interacts with lipoproteins and violates the permeability of cell membranes. It has antiseptic properties, is active against gram-positive bacteria, has a fungicidal effect on Candida albicans and some lipophilic viruses. Tyrothricin is a local antibiotic, is a mixture of antimicrobial linear and cyclic polypeptides, isolated at the stage of fermentation of Brevibacillus brevis Dudos, consisting mainly of graphite and glycytacyte-glycytacyte-glycetacyte – glycyte – graphite – line –– –– ––––––––––––––––––––––––––––––––––––– program, is composed mainly of an Gramcydine – Cycidine – Cycidine – Cycidine – Cycidine – Cycidine – Cycidine – Cycidine – Cycidine – Cycidine – Cycidine – Cycidine – Cycidine – Symithycidine – Symidara – Synthetic antibiotic virus. . Tyrothricin acts bactericidal, causing rupture of phosphorylation processes in the chain of cellular respiration and destroying the membranes of bacterial cells. Due to the specific mechanism of action of thyrothricin, which is absent in antibiotics of systemic action, cross-resistance to the drug does not occur.
Pharmacokinetics
Benzocaine is slightly soluble in water, which causes its slow absorption. Like all ether derivatives of para-aminobenzoic acid, it is cleaved by esterase in the blood plasma and liver. As a result, para-aminobenzoic acid and ethyl alcohol are metabolized to acetyl coenzyme A. Para-aminobenzoic acid is conjugated with glycine or excreted by the kidneys unchanged. Benzalkonium chloride is practically not absorbed, does not have a resorptive effect, and is excreted by the kidneys. No accumulation of a substance in body tissues was detected. Thyrothricin - due to low systemic absorption, there are no data on pharmacokinetics. Does not affect the intestinal microflora.
Indications
Infectious and inflammatory diseases of the oral cavity and pharynx, accompanied by pain syndrome: - pharyngitis, laryngitis, the initial stage of tonsillitis; - inflammation of the gums and oral mucosa (gingivitis, stomatitis).
Contraindications
- increased individual sensitivity to any of the components of the drug; - hereditary fructose intolerance and glucose / galactose absorption disorder syndrome or sucrase / isomaltase deficiency; - children under 6 years of age.
Use during pregnancy and lactation
Use of the drug Doritricin during pregnancy and lactation is possible if the expected benefit to the mother outweighs the potential risk to the fetus.
Dosage and administration
Inside Adults and children over 6 years, slowly dissolve in the oral cavity, 1 tablet every 3 hours. The maximum daily dose is 6 pills. The course of treatment is 7 days. Increase the course of therapy if necessary - on the recommendation of a doctor.
Side effects
Allergic reactions are possible, rarely - gastrointestinal disorders (nausea, diarrhea). If any of the side effects indicated in the instructions are exacerbated, or you notice any other side effects not indicated in the instructions, inform your doctor.
Overdose
In the recommended doses, cases of overdose are not described. Accidental intake of large doses of Doritricin can cause disorders of the digestive system (nausea, vomiting, diarrhea). In this case, you must flush the stomach, take activated charcoal and consult a doctor.
Interaction with other drugs
No cases of clinically significant drug interactions with Doritricin have been described.
special instructions
Information for patients with diabetes mellitus: in 1 tablet of the drug the carbohydrate content is approximately 0.07 bread units (CU). The effect on the ability to drive motor vehicles and control mechanisms is not affected.