Erythromycin pills 250 mg 20 pcs
Condition: New product
991 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Erythromycin
Release form
Pills
Composition
1 tablet contains: Erythromycin 250 mg. Adjuvants: povidone - 9.45 mg, crospovidone - 13.5 mg, calcium stearate - 4.14 mg, talc - 10.35 mg, potato starch - up to a kernel weight of 450 mg. 0.8 mg, castor oil 3 mg.
Pharmacological effect
An antibiotic group macrolides. It has a bacteriostatic effect. However, in high doses in relation to sensitive microorganisms has a bactericidal effect. Erythromycin reversibly binds to the ribosomes of bacteria, thereby inhibiting protein synthesis. Active against gram-positive bacteria: Staphylococcus spp. (strains producing and not producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae); Gram-negative bacteria: Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis, Brucella spp., Legionella spp., Bacillus anthracis, Corynebacterium diphtheriae; anaerobic bacteria: Clostridium spp. Erythromycin is also active against Mycoplasma spp., Chlamydia spp., Spirochaetaceae, Rickettsia spp. Gram-negative rods are resistant to erythromycin, including Escherichia coli, Pseudomonas aeruginosa, Shigella spp., Salmonella spp.
Pharmacokinetics
Bioavailability is 30-65%. Distributed in most tissues and body fluids. Plasma protein binding is 70-90%. Metabolized in the liver, partly with the formation of inactive metabolites. T1 / 2 - 1.4-2 hours. Derived from the bile and urine.
Indications
Bacterial infections caused by sensitive microflora: diphtheria (including bacteriocarrier), whooping cough (including prevention), brucellosis, legionnaire's disease, erythrasma, listeriosis, scarlet fever, amebic dysentery, gonorrhea; urinary infections in pregnant women caused by Chlamydia trachomatis; primary syphilis (in patients with allergies to penicillins) uncomplicated chlamydia in adults (localized in the lower urinary tract and rectum) with intolerance or failure of tetracyclines, etc .; infections of upper respiratory tract (tonsillitis, otitis media, sinusitis); biliary tract infection (cholecystitis); infections of the upper and lower respiratory tract (tracheitis, bronchitis, pneumonia); infections of the skin and soft tissues (pustular skin diseases, including juvenile acne, infected wounds, pressure sores, burns of the II-III centuries, trophic ulcers).
Contraindications
Hypersensitivity to macrolide antibiotics or to any other substance that is part of the drug, simultaneous administration of terfenadine or astemizole, a significant decrease in hearing.
Precautionary measures
With caution used for violations of the liver, kidneys.
Use during pregnancy and lactation
Erythromycin penetrates the placental barrier, is excreted in breast milk. When using erythromycin during pregnancy, the expected benefits to the mother and the potential risk to the fetus should be assessed. If necessary, use during lactation should decide on the termination of breastfeeding.
Dosage and administration
The drug must be taken orally on an empty stomach or 1 hour before a meal. The tablet cannot be divided and chewed. Erythromycin must be taken at least 2–3 days after the symptoms of the disease disappear. For infections caused by group A streptococcus, erythromycin should be taken for at least 10 days. The dose depends on clinical and microbiological studies, as well as on the general condition of the patient. The average daily dose for adults is 1 to 2 g in 2-4 doses, the maximum daily dose is 4 To children under the age of 18, depending on the age, body weight and severity of the infection, 30-50 mg / kg / day in 2-4 doses. In severe infections, the dose can be doubled. For the treatment of diphtheria carrier - 0.25 g 2 times a day. The course dose for the treatment of primary syphilis is 30-40 g, the duration of treatment is 10-15 days. For amebic dysentery for adults, 0.25 g 4 times a day, for children 30-50 mg / kg / day; duration of the course is 10-14 days. For legionellosis - 0.5-1 g 4 times a day for 14 days. For gonorrhea - 0.5 g every 6 hours for 3 days, then 0.25 g every 6 hours for 7 days. For preoperative preparation of the intestine for the prevention of infectious complications - by mouth, 1 g for 19 h, 18 h and 9 h before the start of the operation (3 g in total). For the prevention of streptococcal infection (for tonsillitis, pharyngitis) adults - 20-50 m / kg / day, children - 20-30 mg / kg / day, course duration - at least 10 days. For prophylactic septic endocarditis in bo 1 g for adults and 20 mg / kg for children, 1 hour before the treatment or diagnostic procedure, then 0.5 g for adults and 10 mg / kg for children, again after 6 hours . With pertussis - 40-50 mg / kg / day for 5-14 days.
Side effects
On the part of the digestive system: nausea, vomiting, gastralgia, abdominal pain, tenesmus, diarrhea, dysbiosis, rarely - oral candidiasis, pseudomembranous enterocolitis, abnormal liver function, cholestatic jaundice, increased activity of “hepatic” transaminases, pancreatitis.About diarrhea that occurred during treatment with erythromycin, you must inform the doctor, because this may be a symptom of pseudomembranous enterocolitis. During a long or repeated course of treatment with erythromycin, superinfection may occur due to drug-resistant bacteria or fungi. On the part of the hearing organs: reversible ototoxicity - hearing loss and / or tinnitus (with high doses, more than 4 g / day). From the side of the cardiovascular system: rarely - tachycardia, prolongation of the QT interval on the electrocardiogram, atrial fibrillation and / or flutter (in patients with an extended QT interval on electrocardiogram mme) .Allergic reactions: urticaria, other forms of skin rash, eosinophilia, rarely - anaphylactic shock. Other adverse effects that may occur after taking erythromycin: agranulocytosis, disorders of the nervous system (dizziness, state of confusion, hallucinations), nightmares .
Overdose
Symptoms: abnormal liver function, up to acute liver failure, and hearing loss. Treatment: gastric lavage, forced diuresis, hemo-and peritoneal dialysis. Constant monitoring of vital functions (ECG, electrolyte composition of blood) is performed.
Interaction with other drugs
With simultaneous use of erythromycin with theophylline, aminophylline, caffeine, an increase in their plasma concentration is noted and thus increases the risk of toxic action. Erythromycin increases the concentration of cyclosporine in the blood plasma and may increase the risk of nephrotoxic action. The drugs blocking tubular secretion, prolong T1 / 2 erythromycin. Incompatible with lincomycin, clindamycin and chloramphenicol (antagonism). Erythromycin reduces the bactericidal effect of beta-lactam antibiotics (ne nicillins, cephalosporins, carbapenems). With simultaneous use, erythromycin increases theophylline content. When used simultaneously with drugs that are metabolized in the liver (carbamazepine, valproic acid, hexobarbital, phenytoin, alfentanil, disopyramide, alfastanil, disopyramide, hexobarbital, phenophenol, disopyramide, heparbital, phenophenol, disopyramide, hexobarbital, phenophenol, disopyramide, hepatolbital in plasma (it is an inhibitor of liver microsomal enzymes). In / in the introductionerythromycin enhances the effect of ethanol (accelerating gastric emptying and reducing the duration of action of alcohol dehydrogenase in the gastric mucosa). Erythromycin reduces the clearance of triazolam and midazolam and therefore may increase the pharmacological effects of benzodiazepines. When used simultaneously with terfenadine or astemizol, it is possible to develop an heart warmth, including benzodiazepines. tachycardias, even death); With a snoods
special instructions
Drugs that increase the acidity of gastric juice, and acidic drinks inactivate erythromycin. Erythromycin can not drink milk and dairy products.