Flemoxin SoluTab pills soluble 1000 mg 20 pcs
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Active ingredients
Amoxicillin
Release form
Non-dispersed Tablets
Composition
1 tablet contains: Amoxicillin trihydrate 1165.5 mg, which corresponds to the content of amoxicillin 1000 mg Supplementary substances: lemon flavor - 11.1 mg, mandarin flavor - 9.1 mg, vanillin - 1 mg, crospovidone - 50.4 mg, magnesium stearate - 6 mg, saccharin - 13.1 mg , dispersible cellulose - 34.8 mg, microcrystalline cellulose - 50.5 mg.
Pharmacological effect
A bactericidal, acid-resistant broad-spectrum antibiotic from the group of semi-synthetic penicillins. It violates the synthesis of peptidoglycan (supporting polymer of the cell wall) during the period of division and growth, and causes lysis of bacteria. It is active against gram-positive and gram-negative microorganisms: Streptococcus pyogenes, Streptococcus pneumoniae, Clostridium tetani, Clostridium welchii, Neisseria gonorrhoe, as a part of the lines of the production, as well as the basis of the current, as a part of the basis of the current, as a part of the basis of the same, as a part of the same, as a matter of a quest, it is a part of the basis of the same, as a part of the basis of the primals, the aphorician, aphoric, and a number of ages, a part of a group of atopic chaltephysterol, a cell of the cell wall) during division and growth, causes lysis of bacteria. β-lactamase), Bacillus anthracis, Listeria monocytogenes, Helicobacter pylori. Less active in relation to Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Salmonella typhi, Shigella sonnei, Vibrio cholerae. Proteus spp. (indole-positive strains), Serratia spp., Enterobacter spp. Penicillinase producing strains are resistant to amoxicillin.
Pharmacokinetics
Absorption After ingestion, amoxicillin is absorbed quickly and almost completely (93%), it is not destroyed in the acidic environment of the stomach. Eating almost no effect on the absorption of the drug. After ingestion of 500 mg of amoxicillin Cmax of the active substance, which is 5 μg / ml, is noted in the blood plasma after 2 hours. Increasing or decreasing the dose of the drug by 2 times Cmax in the blood plasma also changes by 2 times. The distribution of plasma protein is 17%. . Amoxicillin penetrates mucous membranes, bone tissue, intraocular fluid and sputum in therapeutically effective concentrations. The concentration of amoxicillin in bile exceeds its concentration in the blood plasma by 2-4 times. In amniotic fluid and umbilical cord vessels, amoxicillin concentration is 25-30% of its level in the blood plasma of a pregnant woman. Amoxicillin poorly penetrates the BBB; however, in inflammation of the meninges, the concentration in the cerebrospinal fluid is about 20% of the concentration in the blood plasma. Small amounts are excreted in breast milk. Metabolism Amoxicillin is partially metabolized in the liver, most of its metabolites are not microbiologically active. form (by canalicular excretion - 80% and glomerular filtration - 20%), by the liver - 10-20%. In the absence of renal impairment, T1 / 2 amoxicillin is 1-1.5 h.In premature babies, newborns and children younger than 6 months - 3-4 hours. Pharmacokinetics in special clinical situations T1 / 2 of amoxicillin does not change if the liver function is abnormal. When kidney function is abnormal (CK ≤ 15 ml / min) anuria 8.5 parts Amoxicillin is removed from the body during hemodialysis.
Indications
Infectious and inflammatory diseases caused by microorganisms susceptible to the drug: - respiratory infections; infections of the urogenital system; infections of the gastrointestinal organs; - infections of the skin and soft tissues.
Contraindications
- Hypersensitivity to the components of the drug; - Hypersensitivity to other beta-lactam antibiotics, including to other penicillins, cephalosporins, carbapenems.
Precautionary measures
The drug should be used with caution in case of polyvalent hypersensitivity to xenobiotics, infectious mononucleosis, lymphocytic leukemia, gastrointestinal tract history (especially with colitis associated with antibiotics), renal failure, during pregnancy and lactation, allergic reactions (including in history).
Use during pregnancy and lactation
Use of the drug Flemoxin Solutab during pregnancy and lactation is possible if the expected benefit of therapy for the mother exceeds the risk of side effects in the fetus and infant. Small amounts of amoxicillin are excreted in breast milk, which can lead to the development of sensitization in the infant baby
Dosage and administration
The drug is taken orally. The drug is prescribed before, during or after a meal. The tablet can be swallowed whole, divided into parts or chewed, washed down with a glass of water, and can also be diluted in water to form a syrup (in 20 ml) or suspension (in 100 ml) with a pleasant fruit taste. The dosing mode is set individually, taking into account the course of the disease, the causative agent's sensitivity to the drug, the patient's age. In case of infectious and inflammatory diseases of mild and moderate severity, the drug is recommended according to the following scheme: adults and children over 10 years old are prescribed 500-750 mg 2 times / s ut or 375-500 mg 3 times / day; children aged 3 to 10 years, appoint 375 mg 2 times / day or 250 mg 3 times / day; children aged 1 to 3 years old are prescribed 250 mg 2 times / day or 125 mg 3 times / day. The daily dose for children (including children up to 1 year old) is 30-60 mg / kg / day,divided into 2-3 doses. When treating severe infections, as well as in difficult-to-reach foci of infection (for example, acute otitis media), it is recommended to take three times. In chronic diseases, recurrent infections, and severe infections, adults are prescribed 0.75-1 g 3 times / day ; children - 60 mg / kg / day, divided into 3 doses. In acute uncomplicated gonorrhea, 3 g of the drug is prescribed in 1 dose in combination with 1 g of probenecid. For patients with impaired renal function with a CC of ≤10 ml / min, the dose is reduced by 15%. 50%. In case of mild to moderate infections, the drug is taken for 5-7 days. However, for infections caused by Streptococcus pyogenes, the duration of treatment should be at least 10 days. The drug should be continued for 48 hours after the symptoms of the disease disappear.
Side effects
On the part of the digestive system: rarely - change in taste, nausea, vomiting, diarrhea, dysbiosis, stomatitis, glossitis; in some cases, a moderate increase in liver transaminases, cholestatic jaundice, hepatic cholestasis, acute cytolytic hepatitis, pseudomembranous and hemorrhagic colitis. From the urinary system: interstitial nephritis, crystalluria. thrombocytopenia, agranulocytosis, hemolytic anemia. On the nervous system: agitation, anxiety, insomnia, ataxia, confusion I, behavior change, depression, peripheral neuropathy, headache, dizziness, epileptic seizures. Allergic reactions: skin reactions, mainly in the form of specific maculo-papular rash, urticaria, skin hyperemia, erythematous rashes, rhinitis, conjunctivitis, multiforme exudation, erythematous rashes, rhinitis, conjunctivitis, multiforme exudation (Stevens-Johnson syndrome), fever, arthralgia, eosinophilia, exfoliative dermatitis, reactions similar to serum sickness, toxic epidermal necrolysis, allergic vasculitis, acute generalized first exanthematous pustullez; in some cases - anaphylactic shock, angioedema. Other: difficulty breathing, vaginal candidiasis, superinfection (especially in patients with chronic diseases or low body resistance).
Overdose
Symptoms: GIT dysfunction - nausea, vomiting, diarrhea; a consequence of vomiting and diarrhea can be a violation of water and electrolyte balance. Treatment: prescribe gastric lavage, activated carbon, saline laxatives; apply measures to maintain water and electrolyte balance, hemodialysis.
Interaction with other drugs
Probenecid, phenylbutazone, oxyphenbutazone, diuretics, allopurinol, NSAIDs, to a lesser extent - acetylsalicylic acid and sulfinpyrazone suppress penicillin tubular secretion, which leads to an increase in T1 / 2 and an increase in the concentration of amoxicillin in blood plasma. cephalosporins, vancomycin, rifampicin) are synergized at the same time. Antagonism is possible when taken with certain bacteriostatic drugs (for example, chloramphenicol, sulfonamides). Simultaneous use of a oksitsillina with estrogen-containing oral contraceptives can reduce the effectiveness of the latter and increase the risk of acyclic krovotecheniy.Antatsidy, glucosamine, laxatives, drugs, aminoglycosides, reduce the absorption of food. Ascorbic acid increases absorption. Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); enhances digoxin absorption. Simultaneous use of amoxicillin with allopurinol increases the risk of skin rash.
special instructions
Prescribing the drug to patients with infectious mononucleosis and lymphocytic leukemia should be used with caution, since the appearance of a non-allergic eye is high. The presence of erythroderma in history does not constitute a contraindication for the administration of the drug Flemoxin Solutab. colitis is an indication for discontinuation of the drug. During course treatment, it is necessary to monitor the condition functions of the blood-forming organs, liver and kidneys. Superinfection is possible due to the growth of microflora insensitive to the drug, which requires a corresponding change in antibiotic therapy. When treating mild diarrhea during the course of treatment, avoid diarrheal drugs that reduce intestinal motility; kaolin or attapulgite-containing anti-diarrhea drugs may be used.Treatment continues for another 48-72 hours after the disappearance of the clinical symptoms of the disease. If estrogen-containing oral contraceptives and amoxicillin are used at the same time, other or additional contraceptive methods should be used, if possible. Effect on ability to drive and control mechanisms No adverse effects of the drug on the ability to to the management of vehicles or work with mechanisms.