Gennepriston pills 10 mg N1
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Active ingredients
Mifepristone
Release form
Pills
Composition
In 1 tablet: mifepristone 10 mg. Auxiliary substances: microcrystalline cellulose - 74.6 mg, sodium carboxymethyl starch - 4.5 mg, calcium stearate - 900 μg.
Pharmacological effect
Synthetic steroid anti-progestogen, (blocks the action of progesterone at the receptor level), does not possess gestagen activity. Antagonism with glucocorticoids is noted (due to competition at the level of communication with receptors). Increases the contractility of the myometrium, stimulating the release of interleukin-8 in choriodecidual cells and increasing the sensitivity of myometrium to prostaglandins. Depending on the phase of the menstrual cycle, it causes inhibition of ovulation, a change in the endometrium, and prevents the implantation of a fertilized egg.
Pharmacokinetics
Absorption: After a single oral administration at a dose of 600 mg Cmax is achieved in 1.3 hours and is 1.98 mg / l. Absolute bioavailability is 69%. Distribution: Binding to plasma proteins (with albumin and acid α1-glycoprotein) is 98%. Excretion: T1 / 2 - 18 hours blood decreases by 2 times between 12-72 h), then the phase of rapid elimination.
Indications
Emergency post-contraceptive contraception (after unprotected intercourse or if the method of contraception used cannot be considered reliable.
Contraindications
Adrenal insufficiency; - long-term use of GCS; - acute or chronic renal failure; - acute or chronic liver failure; - presence of severe extragenital pathology; - hypersensitivity to mifepristone (in history).
Precautionary measures
With caution, you should prescribe the drug in violation of hemostasis (including previous treatment with anticoagulants), chronic obstructive pulmonary diseases (including bronchial asthma), severe hypertension, heart rhythm disturbances, chronic heart failure.
Use during pregnancy and lactation
Ginepriston; contraindicated for use during pregnancy. It is necessary to stop breastfeeding for 14 days after taking the drug.
Dosage and administration
The drug is administered orally in a single dose of 10 mg (1 tab.) For 72 hours after unprotected intercourse. To maintain the contraceptive effect, refrain from eating 2 hours before using the drug and for 2 hours after taking. Ginepriston; can be used in any phase of the menstrual cycle.
Side effects
On the part of the digestive system: nausea, vomiting. On the CNS side: dizziness, headache. On the part of the reproductive system: bleeding from the genital tract, menstrual disorders. Allergic reactions: urticaria. Others: discomfort in the lower abdomen, weakness, hyperthermia.
Overdose
Reception of Ginepriston in doses up to 2 g does not cause undesirable reactions. Symptoms: adrenal insufficiency is possible. Treatment: conducting symptomatic therapy.
special instructions
Ginepriston; not recommended for regular use as a planned permanent contraception. The use of the drug Ginepriston; does not protect against sexually transmitted diseases and AIDS. Avoid concurrent use of Ginepriston with NSAIDs.