Nurofen Express forte capsules 400mg N20
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Active ingredients
Ibuprofen
Composition
Ibuprofen 400 mg Auxiliary substances: macrogol 600 - 335.3 mg, potassium hydroxide - 44.82 mg, water - 29.88 mg. The composition of the shell: gelatin - 197 mg, sorbitol (partially dehydrated) - 95.68 mg, water - 25.02 mg, dye crimson [Ponso 4R] (E124) - 0.79 mg, white ink [Opacode WB NS-78-18011] (water - 48 %, titanium dioxide (E171) - 29%, propylene glycol - 10%, isopropanol - 8%, hypromellose 3cP - 5%).
Pharmacological effect
The mechanism of action of ibuprofen, a derivative of propionic acid from the group of nonsteroidal anti-inflammatory drugs (NSAIDs), is due to the inhibition of the synthesis of prostaglandins - mediators of pain, inflammation and hyperthermia. Indiscriminately blocks COX-1 and COX-2, as a result of which it inhibits prostaglandn synthesis. It has a quick directional effect against pain (pain reliever), antipyretic and anti-inflammatory effect. In addition, ibuprofen reversibly inhibits platelet aggregation.
Indications
Headache, toothache, migraine, painful menstruation, neuralgia, back pain, muscle and rheumatic pains. feverish conditions with flu and catarrhal diseases.
Contraindications
Hypersensitivity. erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, including ulcerative colitis . severe arterial hypertension. "Aspirin" bronchial asthma, urticaria, rhinitis, triggered by the administration of acetylsalicylic acid (salicylates) and other NSAIDs. diseases of the optic nerve, impaired color vision, amblyopia, scotoma. deficiency of glucose-6-phosphate dehydrogenase, hemophilia, hypocoagulation state, leukopenia. pregnancy, lactation. renal and / or liver dysfunction. hearing loss, pathology of the vestibular apparatus. children's age up to 12 years.
Use during pregnancy and lactation
Use of the drug in the III trimester of pregnancy is contraindicated. The use of the drug in the I-II trimesters of pregnancy should be avoided; if necessary, the drug should be consulted with a doctor. There is evidence that ibuprofen in small quantities can penetrate into breast milk without any negative consequences for the health of the infant, so usually with a short-term admission there is no need to stop breastfeeding. If necessary, long-term use of the drug should consult a doctor to decide whether to stop breastfeeding for the period of use of the drug.Information for women planning pregnancy: these drugs suppress COX and prostaglandin synthesis, affect ovulation, impairing female reproductive function (reversible after discontinuation of treatment).
Dosage and administration
Adults and children over 12 years old are prescribed inside 200 mg 3-4 times / day. To achieve a rapid therapeutic effect, the dose can be increased to 400 mg 3 times / day. The maximum daily dose for adults is 1.2 g. The maximum daily dose for children and adolescents aged 12 to 17 years is 1 g. Capsules should be taken with water. The patient should be warned that if the symptoms of the disease persist when taking the drug for 2-3 days, it is necessary to stop treatment and consult a doctor.
Side effects
On the part of the digestive system: NPVS-gastropathy (abdominal pain, nausea, vomiting, heartburn, loss of appetite, diarrhea, flatulence, constipation. Possible - increased activity of hepatic transaminases. Rarely - erosive and ulcerative lesions of the gastrointestinal mucosa, which in some cases are complicated perforation and bleeding). irritation or dryness of the oral mucosa, pain in the mouth, ulceration of the mucous membrane of the gums, aphthous stomatitis, pancreatitis, hepatitis CNS: headache, dizziness, insomnia, anxiety, nervousness, irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations. rarely, aseptic meningitis (more often in patients with autoimmune diseases). Since the cardiovascular system: heart failure, tachycardia, increased blood pressure. On the part of the urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis. perhaps - a decrease in QA, an increase in serum concentration of creatinine. On the part of the senses: hearing loss, ringing or tinnitus, toxic lesion of the optic nerve, blurred vision or diplopia, dryness and eye irritation, conjunctival and edema of the eyelids (allergic origin), scotoma. On the part of the respiratory system: shortness of breath, bronchospasm. From the hemopoietic system: anemia (including hemolytic and aplastic), thrombocytopenia, thrombocytopenic purpura, agranulocytosis, leukopenia. possibly an increase in bleeding time,reduction of hematocrit or hemoglobin Allergic reactions: skin rash (usually erythematous or urticaria), pruritus, angioedema, anaphylactoid reactions, anaphylactic shock, bronchospasm or dyspnea, fever, multiforme exudative erythema, etc., etc., etc., etc., etc., etc., etc., etc., etc., etc., etc., etc., etc., etc., etc., etc., etc., etc., etc., etc., etc., etc., etc., etc., etc., in.. toxic epidermal necrolysis (Lyell's syndrome), eosinophilia, allergic rhinitis. Other: increased sweating. may decrease the concentration of glucose in the blood. When using the drug for 2-3 days Side effect is very rare.
special instructions
On the part of the digestive system: NPVS-gastropathy (abdominal pain, nausea, vomiting, heartburn, loss of appetite, diarrhea, flatulence, constipation. Possible - increased activity of hepatic transaminases. Rarely - erosive and ulcerative lesions of the gastrointestinal mucosa, which in some cases are complicated perforation and bleeding). irritation or dryness of the oral mucosa, pain in the mouth, ulceration of the mucous membrane of the gums, aphthous stomatitis, pancreatitis, hepatitis CNS: headache, dizziness, insomnia, anxiety, nervousness, irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations. rarely, aseptic meningitis (more often in patients with autoimmune diseases). Since the cardiovascular system: heart failure, tachycardia, increased blood pressure. On the part of the urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis. perhaps - a decrease in QA, an increase in serum concentration of creatinine. On the part of the senses: hearing loss, ringing or tinnitus, toxic lesion of the optic nerve, blurred vision or diplopia, dryness and eye irritation, conjunctival and edema of the eyelids (allergic origin), scotoma. On the part of the respiratory system: shortness of breath, bronchospasm. From the hemopoietic system: anemia (including hemolytic and aplastic), thrombocytopenia, thrombocytopenic purpura, agranulocytosis, leukopenia. possible - the increase of bleeding time, reduction of the hematocrit or hemoglobin Allergic reactions: skin rash (typically erythematous or urticaria), pruritus, angioedema, anaphylactoid reactions, anaphylactic shock, bronchoconstriction or dyspnea, fever, erythema multiforme (incl Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), eosinophilia, allergic rhinitis.Other: increased sweating. may decrease the concentration of glucose in the blood. When using the drug for 2-3 days Side effect is very rare.