Ornidazole Vertex Tablets 500mg N10
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Active ingredients
Ornidazole
Release form
Pills
Composition
Tablets, film coated 1 tab. ornidazole 500 mg.
Pharmacological effect
Anti-protozoan, a derivative of 5-nitroimidazole. It is believed that the mechanism of action is associated with a violation of the structure of the DNA of sensitive microorganisms. It is active against Trichomonas vaginalis, Giardia lamblia, Entamoeba histolytica, and also against some anaerobic bacteria (including Bacteroides spp., Clostridium spp., Fusobacterium and anaerobic cocci). T1 / 2 ornidazole more than metronidazole.
Pharmacokinetics
After ingestion, absorption from the gastrointestinal tract is high. The time to reach Cmax is 1-2 hours. Plasma protein binding is 15% or more. Penetrates the BBB. T1 / 2 - about 13 hours. It is excreted in the form of metabolites by the kidneys (60-70%) and with feces (20-25%), in unchanged form - about 5%.
Indications
Trichomoniasis, amebiasis (intestinal and non-intestinal forms, including amoebic dysentery and amebic abscess of the liver), giardiasis, prevention of postoperative complications (especially during operations on the colon or in gynecology).
Contraindications
CNS diseases, acute neurological diseases, I trimester of pregnancy, lactation period, hypersensitivity to ornidazole.
Use during pregnancy and lactation
Contraindicated in the first trimester of pregnancy, during lactation. In pregnancy, use is possible only by absolute indications, if the expected benefit to the mother outweighs the potential risk to the fetus.
Dosage and administration
For oral administration, depending on the indications, treatment regimen and the patient's body weight, a single dose for adults varies from 500 mg to 2 g; for children weighing up to 35 kg, the daily dose is 20-40 mg / kg. Frequency of reception and duration of use are set individually. In the form of intravenous infusion in adults, it is used in an initial dose of 0.5-1 g, then the dose is set individually, depending on the indications and the treatment regimen; for children - 20-30 mg / kg / day.
Side effects
On the part of the digestive system: possible - nausea, heartburn, dizziness, drowsiness, skin rash. On the part of the nervous system: possible - headache, dizziness, impaired consciousness, tremor, muscle rigidity, impaired motor coordination, convulsions, sensory or mixed peripheral neuropathy, nausea, vomiting, diarrhea.
Interaction with other drugs
Potentiates the effect of indirect anticoagulants, increases the duration of the action of vecuronium bromide.
special instructions
Does not inhibit alcohol dehydrogenase, therefore it is not incompatible with alcohol.