Pangrol 25000 capsules N50
Condition: New product
1000 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Pancreatin
Release form
Capsules
Composition
Active ingredient: Pancreatin (Pancreatin) Active ingredient concentration (mg): 356.10
Pharmacological effect
The active ingredient of the drug Pangrol 25000 is pancreatin, which is a powder from the pancreas glands. Enzymes that are part of pancreatin, contribute to the breakdown of fats, carbohydrates and proteins from food. Pancreatin, providing a proteolytic, amylolytic and lipolytic effect, compensates for the enzymatic insufficiency of the pancreas, improves the functional state of the gastrointestinal tract, normalizes digestive processes.
Pharmacokinetics
Gelatin capsules of Pangrol 25000 quickly dissolve in the stomach, releasing mini-pills coated with an enteric (acid-resistant) coating. Thus, the enzymes remain protected from inactivation in the acidic environment of the stomach. The release form of the drug provides mixing of mini-pills with intestinal contents and uniform distribution of enzymes. Dissolution of the mini-tablet shell and enzyme activation occurs at a neutral or weakly alkaline pH in the small intestine. Pancreatin is not absorbed in the gastrointestinal tract, excreted in feces.
Contraindications
Acute pancreatitis, exacerbation of chronic pancreatitis, hypersensitivity to pancreatin of porcine origin or other components of the drug.
Use during pregnancy and lactation
In patients with cystic fibrosis who received high doses of pancreatin preparations, the ileum, caecum and colon strictures (fibrosing colonopathy) are described. As a precautionary measure, if unusual symptoms appear or the nature of the symptoms of the underlying disease changes, a medical examination is necessary to exclude colon lesions, especially if the drug is used in a dose of over 10,000 lipase units / kg body weight per day. control mechanismsPantrol 25000 does not affect the performance of potentially hazardous activities that require special attention and speed of reaction.
Dosage and administration
The dose of Pangrol 25000 is selected individually depending on the severity of the disease, as well as the volume and composition of the food intake. Unless otherwise indicated, adults are recommended to take 1-2 capsules of Pangrol 25000 during each meal, swallowing the capsules whole washing it down with a sufficient amount of liquid (for example, a glass of water). If taking a whole capsule for a patient is difficult (for example, in young children or elderly patients), you can pour its contents, for example, into a glass, opening the capsule by separating the lid from the body, and then take the contents (mini-pills) with a little liquid or add to liquid food that does not require chewing (for example, apple sauce or fruit juice). The mixture of mini-pills with food or liquid cannot be stored (taken immediately after preparation). Increasing the dose of the drug should be carried out only under the supervision of a physician, focusing on the dynamics of symptoms (for example, reducing steatorrhea, easing abdominal pain). component of 15000-20000 lipase units / kg of body weight is not recommended to exceed. The duration of the course of treatment is determined by the doctor and depends on the course of the disease. Children dosing regimen and duration of treatment are set the doctor depending on the severity of the disease and the composition of the food at the rate of 500 - 1000 lipase units / kg body weight per meal.
Side effects
Interaction studies were not conducted.
Overdose
Possible side effects are listed below in descending frequency of occurrence: often (> 1/100, <1/10), infrequently (> 1/1000, <1/100), rarely (> 1/10000, <1/1000), very rarely (<1/10000), including individual messages. Disorders of the gastrointestinal tract: Often: nausea, vomiting and bloating. Gastrointestinal disorders are mainly associated with the underlying disease. The frequency of the following adverse reactions was lower or is similar to stacids when using placebo: Very often: pain in the abdomen; often: diarrhea. Disorders from the skin and under likely impacts of tissues: Rare: rash, pruritus, urticaria - to assess the frequency of these cases is not enough.
Interaction with other drugs
Precautionary measures
special instructions
Symptoms: the use of large doses of pancreatic enzymes may be accompanied by hyperuricuria and hyperuricemia in patients with cystic fibrosis. Treatment: drug withdrawal, symptomatic therapy.