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Active ingredients
Drotaverine + Caffeine + Naproxen + Paracetamol + Pheniramine Maleate
Release form
Pills
Composition
Active ingredient: paracetamol 325 mg, naproxen 100 mg, caffeine 50 mg, drotaverine hydrochloride - 40 mg, pheniramine maleate - 10 mg; Concentration of the active substance (mg): 525 mg
Pharmacological effect
Combined medication, has analgesic, anti-inflammatory, antispasmodic, antipyretic effect. Paracetamol is an analgesic antipyretic, has antipyretic and analgesic effect due to COX blockade in the central nervous system and the effect on pain centers and thermoregulation. associated with non-selective suppression of the activity of COX, which regulates the synthesis of prostaglandins. Caffeine - a psychogogic agent, causes an expansion of enosnyh vessels in skeletal muscle, heart, kidney; increases mental and physical performance, helps eliminate fatigue and drowsiness; increases the permeability of histohematogenous barriers and increases the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect. It has a tonic effect on the brain vessels. Drotaverine - has myotropic antispasmodic effect due to inhibition of PDE 4, acts on the smooth muscles of the gastrointestinal tract, biliary tract, urinary system, vessels. Pheniramin is a blocker of histamine H1 receptors. It has antispasmodic and mild sedative effect, reduces the phenomenon of exudation, and also enhances the analgesic effect of paracetamol and naproxen.
Pharmacokinetics
Data on the pharmacokinetics of the drug Pentalgin not provided.
Indications
mild and moderate pain syndrome of various genesis (including pain in the joints, muscles, sciatica, algomenorrhea, neuralgia, headache, migraine, toothache); feverish states, catarrhal and other diseases accompanied by pain and inflammation.
Contraindications
severe liver failure; severe renal failure; peptic ulcer and duodenal ulcer in the acute phase; bronchial asthma; bronchospasm; anemia, leukopenia; states thataccompanied by respiratory depression; traumatic brain injury; severe hypertension; acute myocardial infarction; arrhythmias; alcohol intoxication; glaucoma; glucose-6-phosphate dehydrogenase deficiency; children up to 12 years; hypersensitivity to the drug. The drug should be used with caution in case of mild and moderate arterial hypertension, gastric ulcer and / or duodenal ulcer in remission, as well as in elderly patients.
Precautionary measures
Do not exceed the recommended dose. With caution, you should use the drug in patients with cerebrovascular diseases, diabetes, peripheral artery diseases, ulcers of the gastrointestinal tract in the anamnesis, mild or moderate renal and hepatic insufficiency, viral hepatitis, alcoholic liver damage, benign hyperbilirubinemia ( syndromes of Gilbert, Dubin-Johnson and Rotor), epilepsy, with a tendency to convulsive seizures, deficiency of glucose-6-phosphate dehydrogenase, in patients with fire little age.
Use during pregnancy and lactation
The drug is contraindicated for use during pregnancy. If you need to use the drug during lactation should stop breastfeeding.
Dosage and administration
Pentalgin taken orally 1 tablet 1-3 times a day. The maximum daily dose is 4 pills. The duration of treatment is not more than 3 days as an antipyretic and not more than 5 days as an anesthetic. Continuation of drug treatment is possible only after consulting a doctor.
Side effects
Allergic reactions: skin rash, pruritus, urticaria, angioedema; From the side of blood-forming organs: thrombocytopenia, leukopenia, agranulocytosis, anemia, methemoglobinemia; On the part of the nervous system: agitation, anxiety, increased reflexes, tremor, headache, sleep disturbances, dizziness, decreased concentration of attention; Since the cardiovascular system: heartbeat, arrhythmias, increased blood pressure; On the part of the digestive system: erosive and ulcerative lesions of the gastrointestinal tract, nausea, vomiting, epigastric discomfort, abdominal pain, constipation,abnormal liver function; From the urinary system: renal dysfunction; On the part of the senses: hearing loss, tinnitus, increased intraocular pressure in patients with angle-closure glaucoma; Other: dermatitis, tachypnea (increased breathing).
Overdose
Symptoms: pallor of the skin, anorexia (lack of appetite), abdominal pain, nausea, vomiting, gastrointestinal bleeding, agitation, anxiety, confusion, tachycardia, arrhythmia, hyperthermia (fever), frequent urination, headache, tremor or muscle twitching; epileptic seizures, increased activity of hepatic transaminases, hepatonecrosis, an increase in prothrombin time. Symptoms of abnormal liver function may appear 12-48 hours after an overdose. In severe overdose, liver failure develops with progressive encephalopathy, coma, or death; acute renal failure with tubular necrosis; arrhythmia, pancreatitis. If you suspect an overdose, you should immediately seek medical help. Treatment: gastric lavage followed by the administration of activated carbon. Acetylcysteine is a specific antidote for paracetamol poisoning. The introduction of acetylcysteine is important within 8 hours after taking paracetamol. In case of gastrointestinal bleeding, it is necessary to administer antacids and gastric lavage with ice-cold 0.9% sodium chloride solution; maintenance of ventilation and oxygenation; with epileptic seizures - in / in the introduction of diazepam; maintaining fluid and salt balance.
Interaction with other drugs
While taking the drug Pentalgin with barbiturates, tricyclic antidepressants, rifampicin, ethanol increases the risk of hepatotoxic action (these combinations should be avoided). Paracetamol enhances the effect of anticoagulants of indirect action and reduces the efficacy of uricosuric drugs. increases the risk of acute pancreatitis. Inhibitors of microsomal oxide (includingcimetidine) reduces the risk of hepatotoxic action of paracetamol. When used simultaneously with diflunisal, the plasma concentration of paracetamol increases by 50%, which increases the risk of developing hepatotoxicity. Naproxen can cause a decrease in the diuretic effect of furosemide, an increase in the effect of indirect anticoagulants, increases the toxicity of sulfanilamides and metotreacidos, as well as increase the toxicity of sulfanilamides and metodreacidos, as well as increase the toxicity of sulfanilamides and metotreacidos, and increase the toxicity of sulfanilamides. increases its concentration in the blood plasma. When combined use of caffeine and barbiturates, primidone, anticonvulsants STB (derivatives of hydantoin, especially phenytoin) may increase metabolism and increase the clearance of caffeine; while taking caffeine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin - reduced metabolism of caffeine in the liver (slowing its excretion and increasing concentration in the blood). Simultaneous consumption of caffeine-containing drinks and other means of stimulating the central nervous system can lead to excessive stimulation of the central nervous system .At the simultaneous use of drotaverine can weaken the anti-Parkinsonian effect of levodopa.If the simultaneous use of pheniramine with tranquilizers, hypnotics with COROLLARY, MAO inhibitors, ethanol may increase depressant effect on the central nervous system.
special instructions
It is necessary to avoid the simultaneous use of the drug Pentalgin with other agents containing paracetamol and / or NSAIDs, as well as with means to alleviate the symptoms of a cold, flu and nasal congestion. When using the drug Pentalgin for more than 5-7 days, you should monitor peripheral blood parameters and the functional state of the liver. Paracetamol distorts the results of laboratory studies of glucose and uric acid in the blood plasma. If it is necessary to determine the 17-keto steroids, Pentalgin should be canceled 48 hours before research. It should be borne in mind that naproxen increases bleeding time. The effect of caffeine on the central nervous system depends on the type of nervous system and may manifest as excitation and inhibition of higher nervous activity. During treatment, you should not drink alcoholic beverages. Effect on driving ability and control mechanisms In the period treatment, the patient must take care when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and attention. trots of psychomotor reactions.