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Active ingredients
Drotaverine + Caffeine + Naproxen + Paracetamol + Pheniramine Maleate
Release form
Pills
Composition
Paracetamol 325 mg naproxen 100 mg caffeine 50 mg drotaverine hydrochloride 40 mg pheniramine maleate 10 mg Excipients: microcrystalline cellulose - 128 mg, potato starch - 55.38 mg, croscarmellose sodium - 32 mg, hyprolose (hydroxypropylcellulose) - 32.52 mg, citric acid, citric acid, 32 mg, citrate 3 mg, butylhydroxytoluene (E321) - 0.3 mg, magnesium stearate - 7.2 mg, talc - 16.12 mg, dye quinoline yellow (E104) - 0.4608 mg, indigo carmine (E132) - 0.0192 mg. The composition of the shell: hypromellose (hydroxypropyl methylcellulose) - 12.17 mg, povidone (medical polyvinylpyrrolidone, Povidone K25) - 3.87 mg, polysorbate 80 (Tween 80) - 1.1 mg, titanium dioxide - 3.43 mg, talc - 4.218 mg, dye quinoline yellow ) - 0.2 mg, indigo carmine (E132) - 0.0127 mg, or Opadray shell 13A210001 Green (OPADRY 13A210001 GREEN) - 25.0007 mg [hypromellose - 12.17 mg, povidone - 3.87 mg, polysorbate 80 - 1.1 mg, titanium dioxide - 3.43 mg, talc - 4.218 mg, quinoline yellow - 0.2 mg, DF & C blue # 2 / indigo carmine - 0.0127 mg].
Pharmacological effect
The combined drug has analgesic, anti-inflammatory, antispasmodic, antipyretic effect. Paracetamol is an antipyretic analgesic that has antipyretic and analgesic effects due to blockade of COX in the central nervous system and effects on pain and thermoregulation centers. Naproxen - NSAIDs, has anti-inflammatory, analgesic and antipyretic effects associated with non-selective suppression of the activity of COX, which regulates the synthesis of prostaglandins. Caffeine is a psychostimulant and causes dilation of the blood vessels of the skeletal muscles, heart and kidneys. improves mental and physical performance, helps eliminate fatigue and drowsiness. increases the permeability of histohematic barriers and increases the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect. It has a tonic effect on the vessels of the brain. Drotaverine - has myotropic antispasmodic effect due to inhibition of PDE 4, acts on the smooth muscles of the gastrointestinal tract, biliary tract, genitourinary system, blood vessels. Pheniramine is a histamine H1 receptor blocker. It has an antispasmodic and mild sedative effect, reduces the effects of exudation, and also enhances the analgesic effect of paracetamol and naproxen.
Indications
mild and moderately pronounced pain syndrome of various genesis (includingpains in joints, muscles, radiculitis, algomenorrhea, neuralgia, headache, migraine, toothache). feverish states, catarrhal and other diseases accompanied by pain and inflammation.
Contraindications
severe liver failure. renal failure severe. peptic ulcer and duodenal ulcer in the acute phase. bronchial asthma . bronchospasm. anemia, leukopenia. conditions accompanied by respiratory depression. traumatic brain injury. arterial hypertension severe. acute myocardial infarction. arrhythmias. alcohol intoxication. glaucoma deficiency of glucose-6-phosphate dehydrogenase. children's age up to 12 years. hypersensitivity to the drug. The drug should be used with caution in case of mild and moderate arterial hypertension, gastric ulcer and / or duodenal ulcer in remission, as well as in elderly patients.
Use during pregnancy and lactation
The drug is contraindicated for use in pregnancy. If necessary, the use of the drug during lactation should stop breastfeeding.
Dosage and administration
Pentalgin taken orally 1 tablet 1-3 times a day. The maximum daily dose is 4 pills. The duration of treatment is not more than 3 days as an antipyretic and not more than 5 days as an anesthetic. Continuation of drug treatment is possible only after consulting a doctor.
Side effects
Allergic reactions: skin rash, itching, urticaria, angioedema. From the side of blood-forming organs: thrombocytopenia, leukopenia, agranulocytosis, anemia, methemoglobinemia. On the part of the nervous system: agitation, anxiety, increased reflexes, tremor, headache, sleep disturbances, dizziness, decreased concentration of attention. Since the cardiovascular system: heartbeat, arrhythmias, increased blood pressure. On the part of the digestive system: erosive and ulcerative lesions of the gastrointestinal tract, nausea, vomiting, epigastric discomfort, abdominal pain, constipation, and impaired liver function. On the part of the urinary system: renal dysfunction. On the part of the senses: hearing loss, tinnitus, increased intraocular pressure in patients with angle-closure glaucoma. Other: dermatitis, tachypnea (increased breathing).
special instructions
Allergic reactions: skin rash, itching, urticaria, angioedema. From the side of blood-forming organs: thrombocytopenia, leukopenia, agranulocytosis, anemia, methemoglobinemia. On the part of the nervous system: agitation, anxiety, increased reflexes, tremor, headache, sleep disturbances, dizziness, decreased concentration of attention. Since the cardiovascular system: heartbeat, arrhythmias, increased blood pressure. On the part of the digestive system: erosive and ulcerative lesions of the gastrointestinal tract, nausea, vomiting, epigastric discomfort, abdominal pain, constipation, and impaired liver function. On the part of the urinary system: renal dysfunction. On the part of the senses: hearing loss, tinnitus, increased intraocular pressure in patients with angle-closure glaucoma. Other: dermatitis, tachypnea (increased breathing).