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Active ingredients
Methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline
Release form
Drops
Composition
1 ml contains: methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline 10 mg.
Pharmacological effect
Semax has an original mechanism of neurospecific action on the central nervous system (CNS). Semax is a synthetic analogue of corticotropin, which has nootropic properties and is completely devoid of hormonal activity. The drug improves the cognitive, or cognitive processes of the brain, such as memory, learning ability. Increases mental performance; improves the adaptation of brain cells to hypoxia, anesthesia and other damaging effects. The drug is practically non-toxic with a single and long-term administration. Does not show allergic, embryotoxic, teratogenic and mutagenic properties. Does not have a local irritating effect.
Pharmacokinetics
Absorbed from the mucous membrane of the nasal cavity, while absorbed up to 60-70% in terms of the active substance. Semax is quickly distributed to all organs and tissues, penetrates the blood-brain barrier. When released into the blood, Semax undergoes fairly rapid biotransformation and is eliminated from the body with urine.
Indications
Acute ischemic stroke. Transient ischemic attacks. Recovery after a stroke. Acute period of traumatic brain injury.
Contraindications
Hypersensitivity to the components of the drug. Acute psychotic states, disorders accompanied by anxiety. Pregnancy, breastfeeding. Endocrine diseases.
Precautionary measures
Due to the fact that the drug is administered intranasally (in the nose), the simultaneous administration of drugs with a vasoconstrictive effect of a local nature is not recommended.
Use during pregnancy and lactation
Contraindicated. No clinical studies have been conducted.
Dosage and administration
Semax is applied intranasally. As an ambulance in the first minutes and hours of a stroke — at the prehospital stage — Semax 1% is administered 3 drops in each nasal passage every 20 minutes before admission to the hospital.At the stage of treatment in the inpatient hospital, “Semax 1%” is used: A moderate stroke - 3 drops in each nasal passage 4 times a day for 10 days. Severe stroke - 3 drops in each nasal passage 6 times a day for 10 days. Transient ischemic attacks (TIA) treatment at the hospital stage - 3 drops in each nasal passage 3 6 times a day for 10 days.
Side effects
With prolonged use is possible - a slight irritation of the nasal mucosa.
Overdose
The effects of drug overdose have so far failed to reveal even with a significant increase in a single dose.
Interaction with other drugs
Pharmaceutical. Based on the chemical structure of the drug, the presence of chemically incompatible combinations is not expected: the drug is rapidly destroyed and does not enter the gastrointestinal tract. Pharmacokinetic. Considering the chemical structure of the drug (heptapeptide is a synthetic analogue of adrenocorticotropic hormone, completely devoid of hormonal activity), absorption rate and flow rate into the blood, as well as the intraasal route of administration, the effect of other drugs on the pharmacokinetic parameters of Semax is not expected. Given the way of administration of Semax (intranasal), it is undesirable to administer agents with local vasoconstrictor action when administered intranasally.
special instructions
Contraindicated in children under 7 years old, and in ophthalmic and neurosurgical practice, use in children up to 18 years is contraindicated.