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Active ingredients
Sertaconazole
Release form
Cream
Composition
In 1 g - sertaconazole nitrate 20 mg. Auxiliary substances: ethylene glycol and polyethylene glycol palmitostearate - 20 g, saturated polyglycolized glycerides - 5 g, glycerol isostearate - 2 g, paraffin oil - 8 g, methyl p-hydroxybenzoate - 0.1 g, sorbic acid - 0.1 g, purified water - up to 100 g
Pharmacological effect
Antifungal broad-spectrum drug, a derivative of imidazole and benzothiophene. Active against pathogenic fungi Candida albicans, Candida tropicalis, Candida spp., Pityrosporum orbiculare, Trymatophyton spp., Microsporum spp. and causative agents of infections of the skin and mucous membranes (gram-positive strains of Streptococcus spp. and Staphylococcus spp.). It has a fungistatic and fungicidal effect in therapeutic doses. The mechanism of action of sertaconazole is to inhibit the synthesis of ergosterol (the main sterol of the membrane of fungi and yeast), and increase the increase in the synthesis of ergosterol (Yeast). , which leads to the lysis of the cell fungus.
Pharmacokinetics
With the local application of sertaconazole, nitrate is not detected in the blood and urine.
Indications
Superficial mycoses of the skin: - mycoses of the legs, feet and hands; - mycoses of the body; - mycoses of the beard; - candidiasis; - Multi-colored lichen.
Contraindications
- hypersensitivity to sertaconazole, imidazole derivatives or other components of the drug.
Use during pregnancy and lactation
In pregnant women, the safety of the drug has not been specifically studied. Use of the drug during pregnancy is possible only in cases where the intended benefit of therapy for the mother exceeds the potential risk to the fetus. During lactation, you should not apply the cream on the mammary glands. Data on the use of the drug in the period of lactation is currently not available, so if necessary, the appointment of the drug to the mother during lactation should individually decide on the termination of breastfeeding.
Dosage and administration
The cream should be applied to the affected skin with a uniform thin layer 2 times / day with the capture of approximately 1 cm of the surface of healthy skin. The duration of treatment depends on the etiology of the pathogen and the localization of the infection. Symptoms of the disease disappear, usually in 2-4 weeks. The recommended duration of treatment is 4 weeks.
Side effects
Local reactions: contact dermatitis. Fast erythematous reactions that do not require drug withdrawal are possible.
Overdose
Given the external method of use, overdose of the drug Zalain is unlikely. In case of accidental ingestion of the drug, symptomatic treatment is indicated.
Interaction with other drugs
Clinically significant drug interaction of the drug Zalain with other drugs is not installed.
special instructions
The drug is not used in ophthalmic practice. It is not recommended to use acidic detergents (in an acidic environment, the multiplication of Candida spp. Intensifies.).