Allopurinol pills 100mg N50,

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Composition Allopurinol 100 mg Pharmacological action A means that violates the synthesis of uric acid. It is a structural analogue of hypoxanthine. Inhibits the enzyme xanthine oxidase, which is involved in the conversion of hypoxanthine to xanthine and xanthine to uric acid. This is due to a decrease in the concentration of uric acid and its salts in body fluids and urine, which helps dissolve existing urate deposits and prevent their formation in tissues and kidneys. Allopurinol increases the excretion of hypoxanthin and xanthine with urine.

Dosage and administration

Set individually, under the control of the concentration of urate and uric acid in the blood and urine. Adults with ingestion - 100-900 mg / day, depending on the severity of the disease. Frequency of admission 2-4 times / day after meals. Children under 15 years old - 10-20 mg / kg / day or 100-400 mg / day. Maximum doses: in cases of impaired renal function (including those caused by uric nephropathy) - 100 mg / day. Increasing the dose is possible in cases when, against the background of therapy, an increased concentration of urates in the blood and urine is maintained. Precautions During the period of treatment may worsen psoriasis. With pheochromocytoma, propranolol can be used only after taking an alpha blocker. After a long course of treatment, propranolol should be discontinued gradually, under the supervision of a physician. Against the background of treatment with propranolol, IV administration of verapamil, diltiazem should be avoided. A few days before anesthesia, you must stop taking propranolol or pick up a remedy for anesthesia with minimal negative inotropic effects. Influence on the ability to drive vehicles and control mechanisms In patients whose activities require increased attention, the question of the use of propranolol on an outpatient basis should be addressed only after evaluating the individual response of the patient. Side effect From the side of the cardiovascular system: in isolated cases - arterial hypertension, bradycardia. On the part of the digestive system: possible dyspeptic phenomena (including nausea, vomiting), diarrhea, transient increase in transaminase activity in the blood serum. rarely - hepatitis. in rare cases, stomatitis, abnormal liver function (transient increase in transaminase and alkaline phase activity), steatorrhea.On the part of the central nervous system and peripheral nervous system: in isolated cases - weakness, fatigue, headache, dizziness, ataxia, drowsiness, depression, coma, paresis, paresthesia, convulsions, neuropathy, visual disturbances, cataracts, changes in the optic papilla, disorders of taste sensations. From the hematopoietic system: in some cases - thrombocytopenia, agranulocytosis and aplastic anemia, leukopenia (most likely in patients with impaired renal function). From the urinary system: rarely - interstitial nephritis. in isolated cases - edema, uremia, hematuria. On the part of the endocrine system: in rare cases - infertility, impotence, gynecomastia, diabetes mellitus. On the part of metabolism: in isolated cases - hyperlipidemia. Allergic reactions: skin rash, hyperemia, itching. in some cases - angioimmunoblastic lymphadenopathy, arthralgia, fever, eosinophilia, fever, Stevens-Johnson syndrome, Lyell's syndrome. Dermatological reactions: in isolated cases - furunculosis, alopecia, hair discoloration. Specific guidance With caution should be used allopurinol for violations of the liver and / or kidneys (in both cases, a dose reduction is necessary), thyroid hypofunction. In the initial period of the course of therapy with allopurinol, systematic evaluation of indicators of liver function is necessary. During the period of treatment with allopurinol, the daily amount of fluid consumed must be at least 2 liters (under the control of diuresis). At the beginning of the course of treatment for gout, an exacerbation of the disease may occur. For prevention, you can apply NSAIDs or colchicine (0.5 mg 3 times / day). It should be borne in mind that with adequate therapy with allopurinol, the dissolution of large urate stones in the renal pelvis and their subsequent entry into the ureter may occur. Asymptomatic hyperuricemia is not an indication for the use of allopurinol. In children, it is used only for malignant neoplasms (especially leukemia), as well as for some enzyme disorders (Lesch-Nihena syndrome). To correct hyperuricemia in patients with neoplastic diseases, allopurinol is recommended to be used before starting treatment with cytostatics. In such cases, the minimum effective dose should be applied.In addition, in order to reduce the risk of xanthine deposits in the urinary tract, it is necessary to take measures to maintain optimal diuresis and alkalinization of urine. With the simultaneous use of allopurinol and cytostatics, more frequent monitoring of the pattern of peripheral blood is necessary. In the period of taking allopurinol alcohol is not allowed. Influence on the ability to drive motor vehicles and control mechanisms Use with caution in patients whose activities require a high concentration of attention and quick psychomotor reactions. Use during pregnancy and breastfeeding Contraindicated for use during pregnancy and lactation (breastfeeding). Type: Medicine Quantity in the package, pcs: 50 Shelf life: 60 months Active ingredient: Allopurinol (Allopurinol) Route of administration: Oral Vacation order: Prescription Release form: Prescription Storage conditions: In a dry place, In a dark place, Keep out of reach of children Maximum storage temperature, ° C: 30 Pharmacological group: M04AA01 Allopurinol

Active ingredients

Allopurinol

Release form

Pills

Composition

Allopurinol 100 mg

Pharmacological effect

A means of violating the synthesis of uric acid. It is a structural analogue of hypoxanthine. Inhibits the enzyme xanthine oxidase, which is involved in the conversion of hypoxanthine to xanthine and xanthine to uric acid. This is due to a decrease in the concentration of uric acid and its salts in body fluids and urine, which helps dissolve existing urate deposits and prevent their formation in tissues and kidneys. Allopurinol increases the excretion of hypoxanthin and xanthine with urine.

Indications

Treatment and prevention of gout and hyperuricemia of various genesis (including in combination with nephrolithiasis, renal failure, urate nephropathy). Recurrent mixed oxalate-calcium kidney stones in the presence of hyperuricuria. Increased urate formation due to enzyme disorders. Prevention of acute nephropathy with cytostatic and radiation therapy of tumors and leukemias, as well as with complete therapeutic fasting.

Contraindications

Severe disorders of the liver and / or kidneys, pregnancy, lactation, hypersensitivity to allopurinol.

Use during pregnancy and lactation

It is contraindicated for use during pregnancy and lactation (breastfeeding).

Dosage and administration

Set individually, under the control of the concentration of urate and uric acid in the blood and urine. Adults with ingestion - 100-900 mg / day, depending on the severity of the disease. Frequency of admission 2-4 times / day after meals. Children under 15 years old - 10-20 mg / kg / day or 100-400 mg / day. Maximum doses: in cases of impaired renal function (including those caused by uric nephropathy) - 100 mg / day. Increasing the dose is possible in cases when, against the background of therapy, an increased concentration of urates in the blood and urine is maintained.

Side effects

Since the cardiovascular system: in rare cases - arterial hypertension, bradycardia. On the part of the digestive system: possible dyspeptic phenomena (including nausea, vomiting), diarrhea, transient increase in transaminase activity in the blood serum. rarely - hepatitis. in rare cases, stomatitis, abnormal liver function (transient increase in transaminase and alkaline phase activity), steatorrhea. On the part of the central nervous system and peripheral nervous system: in isolated cases - weakness, fatigue, headache, dizziness, ataxia, drowsiness, depression, coma, paresis, paresthesia, convulsions, neuropathy, visual disturbances, cataracts, changes in the optic papilla, disorders of taste sensations. From the hematopoietic system: in some cases - thrombocytopenia, agranulocytosis and aplastic anemia, leukopenia (most likely in patients with impaired renal function). From the urinary system: rarely - interstitial nephritis. in isolated cases - edema, uremia, hematuria. On the part of the endocrine system: in rare cases - infertility, impotence, gynecomastia, diabetes mellitus. On the part of metabolism: in isolated cases - hyperlipidemia. Allergic reactions: skin rash, hyperemia, itching. in some cases - angioimmunoblastic lymphadenopathy, arthralgia, fever, eosinophilia, fever, Stevens-Johnson syndrome, Lyell's syndrome. Dermatological reactions: in isolated cases - furunculosis, alopecia, hair discoloration.

special instructions

Since the cardiovascular system: in rare cases - arterial hypertension, bradycardia. On the part of the digestive system: possible dyspeptic phenomena (including nausea, vomiting), diarrhea, transient increase in transaminase activity in the blood serum. rarely - hepatitis. in rare cases, stomatitis, abnormal liver function (transient increase in transaminase and alkaline phase activity), steatorrhea. On the part of the central nervous system and peripheral nervous system: in isolated cases - weakness, fatigue, headache, dizziness, ataxia, drowsiness, depression, coma, paresis, paresthesia, convulsions, neuropathy, visual disturbances, cataracts, changes in the optic papilla, disorders of taste sensations. From the hematopoietic system: in some cases - thrombocytopenia, agranulocytosis and aplastic anemia, leukopenia (most likely in patients with impaired renal function). From the urinary system: rarely - interstitial nephritis. in isolated cases - edema, uremia, hematuria. On the part of the endocrine system: in rare cases - infertility, impotence, gynecomastia, diabetes mellitus. On the part of metabolism: in isolated cases - hyperlipidemia. Allergic reactions: skin rash, hyperemia, itching. in some cases - angioimmunoblastic lymphadenopathy, arthralgia, fever, eosinophilia, fever, Stevens-Johnson syndrome, Lyell's syndrome. Dermatological reactions: in isolated cases - furunculosis, alopecia, hair discoloration.

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