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Active ingredients
Glucosamine + Chondroitin Sulfate
Release form
Pills
Composition
Active ingredient: Glucosamine hydrochloride 500 mg, Chondroitin sodium sulfate 500 mg Auxiliary substances: disubstituted calcium sulfate, microcrystalline cellulose, croscarmellose sodium, stearic acid, magnesium stearate. Active ingredient concentration (mg): 1000 mg
Pharmacological effect
Stimulator of cartilage tissue regeneration. Glucosamine and chondroitin sodium sulfate are involved in the biosynthesis of connective tissue, helping to prevent the processes of cartilage destruction by stimulating tissue regeneration. The introduction of exogenous glucosamine enhances the production of cartilage matrix and provides non-specific protection, including from NSAIDs and GCS. The drug has a moderate anti-inflammatory effect. Chondroitin sodium sulfate, regardless of whether it is absorbed in intact form or as individual components, serves as an additional substrate for the formation of a healthy cartilage matrix. Stimulates the formation of proteoglycans and type II collagen, and also protects the cartilage matrix from enzymatic degradation (by suppressing the activity of hyaluronidase) and from the damaging effects of free radicals; maintains the viscosity of synovial fluid, stimulates the mechanisms of cartilage repair and inhibits the activity of those enzymes (elastase, hyaluronidase) that break down cartilage. In the treatment of osteoarthritis, it relieves the symptoms of the disease and reduces the need for NSAIDs.
Pharmacokinetics
Absorption The bioavailability of glucosamine when administered orally - 25% (due to the effect of the first passage through the liver). The bioavailability of chondroitin sulfate is 13%. Distribution: Distributed in tissues: the highest concentrations of glucosamine are found in the liver, kidneys, and articular cartilage. About 30% of the dose taken persist for a long time in bone and muscle tissue. ExcretionGlucosamine is excreted mainly in the urine unchanged; partially - with feces. T1 / 2 glucosamine - 68 hours
Indications
Osteoarthritis of the peripheral joints and spine.
Contraindications
Hypersensitivity, marked impaired renal function. With caution: bleeding or bleeding tendency, bronchial asthma, diabetes mellitus.
Precautionary measures
Do not exceed the recommended dose. With caution used for bleeding or bleeding tendency, with bronchial asthma, diabetes.
Use during pregnancy and lactation
The drug Artra is not recommended for use during pregnancy and lactation.
Dosage and administration
Inside Adults and children over 15 years old 1 tablet 2 times a day for the first three weeks; 1 tablet once a day for the next weeks and months. A sustained therapeutic effect is achieved when taking the drug for at least 6 months.
Side effects
Glucosamine: possible dysfunctions of the gastrointestinal tract (epigastric pain, flatulence, diarrhea, constipation), dizziness, skin allergic reactions. Chondroitin: allergic reactions.
Overdose
To date, no cases of overdose of Artra have been reported. Treatment: gastric lavage, symptomatic therapy.
Interaction with other drugs
With simultaneous use may enhance the action of anticoagulants and antiplatelet agents. Increases the absorption of tetracyclines, reduces the effect of semi-synthetic penicillins. The drug is compatible with the GCS.
special instructions
Use in pediatricsClinical data on the efficacy and safety of the use of the drug Artra in children under the age of 15 years are not available. Impact on the ability to drive vehicles and control mechanismsNo data.