More info
Active ingredients
Clenbuterol
Release form
Syrup
Composition
1 ml: Clenbuterol hydrochloride 1 mcg. Adjuvants: sorbitol - 280 mg, glycerol - 200 mg, propylene glycol - 100 mg, sodium citrate dihydrate - 5.8 mg, citric acid monohydrate - 7 mg, methyl parahydroxybenzoate - 0.45 mg, propyl parahydroxybenzoben. butyl parahydroxybenzoate - 0.05 mg, sodium benzoate - 1.2 mg, raspberry essence - 0.45 mg, ethanol 96% - 5 mg, purified water - up to 1 ml.
Pharmacological effect
Clenbuterol is a member of the group of selective β2-adrenomimetics. Clenbuterol is a drug with a rapid bronchodilator effect. Its action is due to the specific stimulation of β2 - adrenergic receptors of smooth muscles. When bound to them, the enzyme adenylate cyclase is activated, which leads to an increase in the intracellular concentration of cyclic adenosine monophosphate and activation of protein kinase A, and deprives myosin of the ability to bind to actin, resulting in relaxation of the bronchi. Clenbuterol stimulates the cells of the mucous membrane of the bronchi and enhances expectoration. At prescribed therapeutic doses, clenbuterol does not affect heart rate or blood pressure.
Pharmacokinetics
Absorption and distribution of Klenbuterol is relatively rapidly absorbed in the gastrointestinal tract. Communication with plasma proteins is 89-98%. Metabolism and excretion Biological T1 / 2 is 3.5 hours. It is eliminated mainly through the kidneys as sulfo-conjugated derivatives.
Indications
- bronchial asthma; - chronic obstructive pulmonary disease (COPD).
Contraindications
- thyrotoxicosis; - hypertrophic obstructive cardiomyopathy; - angle-closure glaucoma; - pheochromocytoma; - tachyarrhythmia; - myocardial infarction (acute period); - pregnancy (I and III trimester); - lactation period; - children up to 6 years; - hypersensitivity; or to any of the excipients.
Precautionary measures
Do not exceed the recommended dose. With caution in the following cases: immediately after myocardial infarction, with hepatic and renal failure, cardiac arrhythmias, myocarditis, mitral valve defects, hypokalemia, unstable or uncompensated diabetes.
Use during pregnancy and lactation
Clenbuterol syrup is not used during the first three months of pregnancy, as well as during the last trimester due to the overwhelming effect on labor. Clenbuterol syrup is not used during breastfeeding. In the second trimester of pregnancy and during breastfeeding, the use of inhaler form of clenbuterol is recommended.
Dosage and administration
The drug is taken orally. The daily dose for children from 6 to 12 years (body weight 22-35 kg) - 15 mcg (for 2 doses). Adults and children over 12 years: 2 times a day for 10-20 mg. Supporting dose - 2 times 10 mcg. The duration of treatment with Clenbuterol is 2–3 days, until the acute symptoms of the disease are relieved. The duration of maintenance therapy should not exceed 7 days. The treatment decision is made by the attending physician for a period longer than seven days.
Side effects
Muscular system: minor tremor of muscles. CNS: anxiety, headache. Cardiovascular system: decrease or increase in blood pressure, tachycardia, anginal pain, ventricular extrasystole. Skin and mucous membranes: skin rash, swelling of the face, nettle rash. , hypoglycemia. ZHKT: gastritis, diarrhea, dry mouth, nausea. Urinary system: impaired urination. The described adverse reactions go away without discontinuing treatment, 1-2 weeks after its onset.
Overdose
Symptoms: tremor of the fingers, increased sweating, headache, tachycardia. In particularly severe cases of overdose of this drug, collapse, convulsions and coma are possible. Immediate measures: in all cases of overdose, clenbuterol is discontinued. Gastric lavage is done, activated carbon is injected, forced diuresis is administered, and symptomatic treatment is initiated. The use of clenbuterol syrup in doses exceeding the recommended, can lead to worsening of the course of bronchial asthma. In such cases, immediate consultation with a doctor and, if necessary, hospitalization is necessary.
Interaction with other drugs
Beta-blockers inhibit the effect of Clenbuterol, and if they are taken simultaneously, there is a risk of developing bronchospasm. Using the drug simultaneously with hypoglycemic agents reduces their effect. Clenbuterol enhances the effect and side effects of beta-adrenomimetics,theophylline and anticholinergics. With simultaneous use of clenbuterol and halogenated hydrocarbons for anesthesia (with manipulations and interventions), there is an increased risk of arrhythmias. tricyclic antidepressants) possible cardiac arrhythmias.
special instructions
The preparation contains the so-called parabens as auxiliary substances: methyl parahydroxybenzoate and propyl parahydroxybenzoate, which can cause urticaria and contact dermatitis (delayed allergic reactions). Rarely, allergic reactions of immediate type (bronchospasm) can occur. The preparation contains glycerol as an excipient, which at high doses can cause headache, gastric irritation and diarrhea. The preparation contains 0.63% by volume of ethyl alcohol. Each dose contains 0.005 grams of alcohol in 1 ml. It is dangerous for people with liver disease, alcoholism, epilepsy, lesions or diseases of the brain, as well as for pregnant women and children. May enhance the effect of other drugs. The drug is not suitable for patients with congenital fructose intolerance due to the presence of sorbitol. Effect on the ability to drive vehicles and control mechanisms. In the first days of treatment, clenbuterol may cause slight tremor and anxiety, which requires increased caution when driving a car and working with equipment.